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| | Celf_0028 | KEGG: glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I. (207 aa) |
| | pat | Histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (355 aa) |
| | Celf_0310 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: gau:GAU_3907 cystathionine beta-synthase. (336 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (452 aa) |
| | Celf_0552 | O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; manually curated; KEGG: O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase. (442 aa) |
| | cysS | TIGRFAM: cysteinyl-tRNA synthetase; KEGG: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; Belongs to the class-I aminoacyl-tRNA synthetase family. (478 aa) |
| | Celf_0736 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (371 aa) |
| | Celf_0743 | KEGG: ornithine aminotransferase; TIGRFAM: ornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (408 aa) |
| | Celf_0744 | PFAM: amidinotransferase; KEGG: amidinotransferase. (281 aa) |
| | Celf_0745 | PFAM: Polyketide cyclase/dehydrase; KEGG: polyketide cyclase/dehydrase. (151 aa) |
| | Celf_0746 | PFAM: aldo/keto reductase; KEGG: aldo/keto reductase. (326 aa) |
| | Celf_0837 | KEGG: HAD-superfamily subfamily IB hydrolase, TIGR01490; TIGRFAM: HAD-superfamily subfamily IB hydrolase, TIGR01490; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase. (279 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (277 aa) |
| | Celf_0981 | PFAM: aminotransferase class I and II; KEGG: aminotransferase class I and II. (410 aa) |
| | Celf_1312 | MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (240 aa) |
| | luxS | Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (155 aa) |
| | Celf_1418 | TIGRFAM: serine O-acetyltransferase; KEGG: serine O-acetyltransferase. (194 aa) |
| | Celf_1419 | KEGG: cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa) |
| | Celf_1437 | KEGG: chorismate mutase; TIGRFAM: chorismate mutase; PFAM: Chorismate mutase, type II. (108 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (305 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (330 aa) |
| | Celf_1593 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (418 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa) |
| | hisC | KEGG: histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (380 aa) |
| | hisB | KEGG: xce:Xcel_1308 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. (202 aa) |
| | Celf_1634 | KEGG: hypothetical protein. (163 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (226 aa) |
| | hisA | TIGRFAM: bifunctional HisA/TrpF protein; KEGG: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein. (246 aa) |
| | Celf_1658 | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (436 aa) |
| | Celf_1659 | PFAM: DSBA oxidoreductase; KEGG: DsbA oxidoreductase. (263 aa) |
| | Celf_1660 | PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: alcohol dehydrogenase zinc-binding domain protein. (338 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (358 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (404 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (328 aa) |
| | argD | KEGG: acetylornithine and succinylornithine aminotransferase; TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (436 aa) |
| | Celf_1665 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (310 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (192 aa) |
| | argG | TIGRFAM: argininosuccinate synthase; KEGG: argininosuccinate synthase; PFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (413 aa) |
| | argH | KEGG: argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase. (473 aa) |
| | Celf_1669 | KEGG: hypothetical protein. (209 aa) |
| | Celf_1670 | KEGG: DNA-3-methyladenine glycosylase; TIGRFAM: DNA-3-methyladenine glycosylase; PFAM: methylpurine-DNA glycosylase (MPG); Belongs to the DNA glycosylase MPG family. (233 aa) |
| | Celf_1717 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); KEGG: phosphoserine phosphatase SerB; PFAM: Haloacid dehalogenase domain protein hydrolase. (231 aa) |
| | Celf_1739 | PFAM: dihydrodipicolinate synthetase; KEGG: dihydrodipicolinate synthase/N-acetylneuraminate lyase; Belongs to the DapA family. (294 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | Celf_1797 | KEGG: hypothetical protein. (214 aa) |
| | Celf_1798 | KEGG: ABC transporter related protein; PFAM: ABC transporter related; ABC transporter transmembrane region; SMART: AAA ATPase. (620 aa) |
| | Celf_1799 | KEGG: ABC transporter related protein; PFAM: ABC transporter related; ABC transporter transmembrane region; SMART: AAA ATPase. (613 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (138 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (522 aa) |
| | Celf_1802 | PFAM: Trp biosynthesis associated, transmembrane protein, Oprn/Chp; KEGG: Trp biosynthesis associated, transmembrane protein, Oprn/Chp. (207 aa) |
| | Celf_1803 | KEGG: hypothetical protein. (101 aa) |
| | Celf_1804 | KEGG: hypothetical protein. (156 aa) |
| | Celf_1805 | KEGG: bcv:Bcav_2222 hypothetical protein. (130 aa) |
| | Celf_1806 | KEGG: hypothetical protein. (209 aa) |
| | trpC | KEGG: indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (270 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (438 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (281 aa) |
| | lgt-2 | Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (293 aa) |
| | Celf_1881 | PFAM: Prephenate dehydrogenase; amino acid-binding ACT domain protein; KEGG: prephenate dehydrogenase. (369 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | hisE | KEGG: xce:Xcel_1730 phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase-like. (87 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (372 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (195 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (396 aa) |
| | Celf_2008 | PFAM: Shikimate dehydrogenase substrate binding domain protein; Shikimate/quinate 5-dehydrogenase; KEGG: shikimate dehydrogenase substrate binding domain protein; Belongs to the shikimate dehydrogenase family. (287 aa) |
| | Celf_2045 | PFAM: Chorismate binding-like; KEGG: chorismate binding-like protein. (388 aa) |
| | Celf_2069 | Tryptophan 5-monooxygenase; KEGG: bcv:Bcav_3578 tyrosine 3-monooxygenase; PFAM: Aromatic amino acid hydroxylase-like. (295 aa) |
| | Celf_2081 | KEGG: nfa:nfa32790 putative arginine/ornithine antiporter; TIGRFAM: arginine/ornithine antiporter; PFAM: amino acid permease-associated region. (494 aa) |
| | arcA | KEGG: sco:SCO0613 arginine deiminase; PFAM: amidinotransferase. (429 aa) |
| | Celf_2137 | PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: cai:Caci_8299 arginase/agmatinase/formiminoglutamase; Belongs to the arginase family. (298 aa) |
| | Celf_2170 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II; Belongs to the class-II DAHP synthase family. (450 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | Celf_2408 | PFAM: Phosphoglycerate mutase; KEGG: phosphoglycerate mutase. (231 aa) |
| | Celf_2410 | KEGG: xce:Xcel_2251 hypothetical protein. (387 aa) |
| | Celf_2412 | KEGG: hypothetical protein. (51 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (437 aa) |
| | Celf_2414 | KEGG: acetyltransferase; manually curated; PFAM: GCN5-related N-acetyltransferase. (197 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (388 aa) |
| | Celf_2435 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein. (324 aa) |
| | Celf_2452 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: xce:Xcel_2290 Cys/Met metabolism pyridoxal-phosphate-dependent protein. (384 aa) |
| | Celf_2454 | KEGG: phospholipid/glycerol acyltransferase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase. (246 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (531 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (436 aa) |
| | Celf_2731 | PFAM: transcriptional coactivator/pterin dehydratase; KEGG: sna:Snas_1906 transcriptional coactivator/pterin dehydratase. (224 aa) |
| | Celf_2750 | PFAM: GCN5-related N-acetyltransferase; KEGG: GCN5-related N-acetyltransferase. (426 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (332 aa) |
| | Celf_2817 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (363 aa) |
| | Celf_2818 | PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; KEGG: homoserine dehydrogenase. (442 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (481 aa) |
| | Celf_2835 | PFAM: aminotransferase class I and II; KEGG: aminotransferase class I and II. (432 aa) |
| | Celf_2889 | KEGG: succinyl-diaminopimelate desuccinylase; TIGRFAM: succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein. (366 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (322 aa) |
| | Celf_2893 | KEGG: succinyldiaminopimelate transaminase; TIGRFAM: succinyldiaminopimelate transaminase; PFAM: aminotransferase class I and II. (383 aa) |
| | Celf_2894 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (108 aa) |
| | Celf_2895 | KEGG: hypothetical protein. (85 aa) |
| | Celf_2949 | KEGG: threonine dehydratase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein. (400 aa) |
| | Celf_2951 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: cystathionine gamma-synthase. (410 aa) |
| | Celf_2962 | TIGRFAM: cystathionine beta-synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; CBS domain containing protein; KEGG: cystathionine beta-synthase; SMART: CBS domain containing protein. (468 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (421 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (352 aa) |
| | Celf_3411 | KEGG: aspartate kinase; TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (427 aa) |
| | Celf_3515 | PFAM: GCN5-related N-acetyltransferase; KEGG: GCN5-related N-acetyltransferase. (179 aa) |
| | pheA | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: prephenate dehydratase. (333 aa) |
| | Celf_3720 | KEGG: methylenetetrahydrofolate reductase (NAD(P)H); PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (363 aa) |
| | metE | 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (773 aa) |
| | Celf_3722 | PFAM: aminotransferase class I and II; KEGG: aminotransferase class I and II. (394 aa) |
