STRINGSTRING
Celf_0022 Celf_0022 Celf_0023 Celf_0023 Celf_0269 Celf_0269 Celf_0437 Celf_0437 dnaK dnaK grpE grpE Celf_0460 Celf_0460 Celf_0461 Celf_0461 Celf_0491 Celf_0491 Celf_0492 Celf_0492 groL groL Celf_0830 Celf_0830 groS groS Celf_1108 Celf_1108 Celf_1109 Celf_1109 Celf_1170 Celf_1170 Celf_1226 Celf_1226 Celf_1367 Celf_1367 clpP clpP clpP-2 clpP-2 clpX clpX Celf_1643 Celf_1643 Celf_1644 Celf_1644 Celf_2186 Celf_2186 Celf_2285 Celf_2285 Celf_2349 Celf_2349 dnaJ dnaJ hrcA hrcA Celf_2352 Celf_2352 Celf_2416 Celf_2416 msrA msrA Celf_3352 Celf_3352 Celf_3436 Celf_3436 Celf_3437 Celf_3437 Celf_3438 Celf_3438 clpB clpB clpP-3 clpP-3 Celf_3798 Celf_3798 Celf_3799 Celf_3799
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Celf_0022Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (179 aa)
Celf_0023KEGG: xce:Xcel_0012 rhomboid family protein; manually curated; PFAM: Rhomboid family protein. (286 aa)
Celf_0269PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; NHL repeat containing protein; KEGG: alkyl hydroperoxide reductase/thiol specific antioxidant/Mal allergen. (639 aa)
Celf_0437KEGG: ach:Achl_2459 heat shock protein DnaJ domain protein. (415 aa)
dnaKChaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (620 aa)
grpEGrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] (214 aa)
Celf_0460KEGG: chaperone DnaJ domain protein; PFAM: chaperone DnaJ domain protein; heat shock protein DnaJ domain protein; SMART: heat shock protein DnaJ domain protein. (328 aa)
Celf_0461Regulatory protein MerR; KEGG: transcriptional regulator, MerR family; PFAM: regulatory protein MerR; SMART: regulatory protein MerR. (138 aa)
Celf_0491KEGG: thioredoxin; TIGRFAM: thioredoxin; PFAM: Thioredoxin domain-containing protein; Belongs to the thioredoxin family. (107 aa)
Celf_0492KEGG: thioredoxin reductase; TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (328 aa)
groLChaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (541 aa)
Celf_0830TIGRFAM: methionine-R-sulfoxide reductase; KEGG: xce:Xcel_0293 methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B; Belongs to the MsrB Met sulfoxide reductase family. (133 aa)
groSChaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (98 aa)
Celf_1108PFAM: Clp domain protein; KEGG: xce:Xcel_0725 Clp domain protein. (179 aa)
Celf_1109KEGG: bcv:Bcav_3019 hypothetical protein. (69 aa)
Celf_1170KEGG: glutaredoxin-like protein; TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin. (87 aa)
Celf_1226PFAM: heat shock protein Hsp20; KEGG: heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family. (146 aa)
Celf_1367KEGG: thioredoxin; TIGRFAM: thioredoxin; PFAM: Thioredoxin domain-containing protein; Belongs to the thioredoxin family. (126 aa)
clpPEndopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (205 aa)
clpP-2Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (233 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (425 aa)
Celf_1643KEGG: catalase; PFAM: Catalase related subgroup; Catalase domain protein; Belongs to the catalase family. (499 aa)
Celf_1644PFAM: ferric-uptake regulator; KEGG: ferric uptake regulator, Fur family; Belongs to the Fur family. (141 aa)
Celf_2186Manganese/iron superoxide dismutase-like protein; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (208 aa)
Celf_2285KEGG: FAD-dependent pyridine nucleotide-disulfide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; Carbamoyl-phosphate synthetase large chain oligomerisation; Rhodanese domain protein; SMART: Rhodanese domain protein. (574 aa)
Celf_2349Protein of unknown function DUF558; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (256 aa)
dnaJChaperone DnaJ domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between [...] (375 aa)
hrcAHeat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (341 aa)
Celf_2352KEGG: hypothetical protein. (285 aa)
Celf_2416SMART: Rhodanese domain protein; KEGG: rhodanese-related sulfurtransferase. (140 aa)
msrAPeptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (222 aa)
Celf_3352KEGG: ATPase AAA-2 domain protein; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; UvrB/UvrC protein; Clp ATPase-like; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. (860 aa)
Celf_3436Response regulator receiver protein; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; response regulator receiver; KEGG: fre:Franean1_2259 response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SMART: response regulator receiver. (563 aa)
Celf_3437Histidine kinase; KEGG: fre:Franean1_2258 cyclic nucleotide-binding protein; PFAM: ATP-binding region ATPase domain protein; cyclic nucleotide-binding; SMART: ATP-binding region ATPase domain protein; cyclic nucleotide-binding. (494 aa)
Celf_3438KEGG: bcv:Bcav_0138 hypothetical protein. (113 aa)
clpBATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (866 aa)
clpP-3Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (206 aa)
Celf_3798KEGG: thioredoxin reductase; TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase. (336 aa)
Celf_3799Thioredoxin; KEGG: xce:Xcel_3369 thioredoxin; TIGRFAM: thioredoxin; PFAM: Thioredoxin domain-containing protein; Belongs to the thioredoxin family. (111 aa)
Your Current Organism:
Cellulomonas fimi
NCBI taxonomy Id: 590998
Other names: C. fimi ATCC 484, Cellulomonas fimi ATCC 484, Cellulomonas fimi DSM 20113, Cellulomonas fimi str. ATCC 484, Cellulomonas fimi strain ATCC 484
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