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Celf_2233 Celf_2233 Celf_2214 Celf_2214 Celf_2133 Celf_2133 Celf_2127 Celf_2127 gpsA gpsA Celf_2505 Celf_2505 leuB leuB ilvC ilvC Celf_2745 Celf_2745 Celf_2818 Celf_2818 Celf_2832 Celf_2832 Celf_2955 Celf_2955 Celf_2991 Celf_2991 Celf_3103 Celf_3103 Celf_3173 Celf_3173 Celf_3191 Celf_3191 Celf_3209 Celf_3209 Celf_3294 Celf_3294 Celf_3295 Celf_3295 Celf_3311 Celf_3311 Celf_3320 Celf_3320 Celf_3326 Celf_3326 Celf_3332 Celf_3332 Celf_3406 Celf_3406 Celf_3457 Celf_3457 Celf_3519 Celf_3519 zwf-2 zwf-2 Celf_3532 Celf_3532 Celf_3611 Celf_3611 Celf_3676 Celf_3676 Celf_2122 Celf_2122 Celf_2119 Celf_2119 Celf_2008 Celf_2008 Celf_1965 Celf_1965 mqo mqo zwf zwf hisD hisD Celf_1593 Celf_1593 ldh ldh dxr dxr Celf_1441 Celf_1441 Celf_1311 Celf_1311 Celf_1299 Celf_1299 Celf_1246 Celf_1246 mdh mdh Celf_1122 Celf_1122 Celf_1076 Celf_1076 guaB guaB Celf_1050 Celf_1050 murB murB Celf_0003 Celf_0003 Celf_0079 Celf_0079 Celf_0150 Celf_0150 Celf_0377 Celf_0377 Celf_0456 Celf_0456 Celf_0481 Celf_0481 Celf_0603 Celf_0603 Celf_0730 Celf_0730 Celf_0835 Celf_0835 Celf_0857 Celf_0857
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Celf_2233TIGRFAM: F420-dependent oxidoreductase, G6PDH family; KEGG: F420-dependent oxidoreductase, G6PDH family. (343 aa)
Celf_2214PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: oxidoreductase domain protein. (348 aa)
Celf_2133TIGRFAM: IMP dehydrogenase family protein; KEGG: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase/GMP reductase; CBS domain containing protein. (484 aa)
Celf_2127PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain-containing protein; KEGG: 3-hydroxyacyl-CoA dehydrogenase NAD-binding protein. (709 aa)
gpsAPFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: glycerol-3-phosphate dehydrogenase (NAD(P)(+)); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (347 aa)
Celf_2505dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (282 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (355 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa)
Celf_2745PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: xce:Xcel_2398 oxidoreductase domain protein. (404 aa)
Celf_2818PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; amino acid-binding ACT domain protein; KEGG: homoserine dehydrogenase. (442 aa)
Celf_2832PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (916 aa)
Celf_2955PFAM: FAD linked oxidase domain protein; D-arabinono-14-lactone oxidase; KEGG: FAD linked oxidase domain protein. (417 aa)
Celf_2991PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase; KEGG: kfl:Kfla_4296 FMN-dependent alpha-hydroxy acid dehydrogenase. (403 aa)
Celf_3103PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: alcohol dehydrogenase GroES domain protein. (382 aa)
Celf_3173PFAM: Luciferase-like, subgroup; KEGG: luciferase-like, subgroup. (310 aa)
Celf_3191PFAM: aldo/keto reductase; KEGG: sro:Sros_7948 aldo/keto reductase. (310 aa)
Celf_3209PFAM: NAD-dependent epimerase/dehydratase; KEGG: xca:xccb100_1728 NAD(P)H-dependent oxidoreductase. (320 aa)
Celf_3294PFAM: Mannitol dehydrogenase domain; Mannitol dehydrogenase rossman domain; KEGG: mannitol dehydrogenase domain protein. (499 aa)
Celf_3295PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: predicted dehydrogenase. (387 aa)
Celf_3311PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: predicted dehydrogenase. (382 aa)
Celf_3320PFAM: Oxidoreductase domain; oxidoreductase domain protein; KEGG: xce:Xcel_2657 oxidoreductase domain protein. (495 aa)
Celf_3326KEGG: bcv:Bcav_3293 L-lactate dehydrogenase (cytochrome); PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase. (403 aa)
Celf_3332PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: predicted dehydrogenase. (382 aa)
Celf_3406PFAM: FAD linked oxidase domain protein; Luciferase-like, subgroup; KEGG: putative F420-dependent oxidoreductase. (749 aa)
Celf_3457KEGG: putative F420-dependent oxidoreductase; TIGRFAM: putative F420-dependent oxidoreductase; PFAM: Luciferase-like, subgroup. (314 aa)
Celf_3519Glycerol-3-phosphate dehydrogenase; KEGG: FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (603 aa)
zwf-2Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (474 aa)
Celf_3532PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: nml:Namu_4438 oxidoreductase domain protein. (349 aa)
Celf_3611TIGRFAM: nucleotide sugar dehydrogenase; KEGG: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (465 aa)
Celf_3676KEGG: F420-dependent oxidoreductase, G6PDH family; TIGRFAM: F420-dependent oxidoreductase, G6PDH family; PFAM: Luciferase-like, subgroup. (327 aa)
Celf_21226-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa)
Celf_2119PFAM: bifunctional deaminase-reductase domain protein; KEGG: pyrimidine reductase, riboflavin biosynthesis. (274 aa)
Celf_2008PFAM: Shikimate dehydrogenase substrate binding domain protein; Shikimate/quinate 5-dehydrogenase; KEGG: shikimate dehydrogenase substrate binding domain protein; Belongs to the shikimate dehydrogenase family. (287 aa)
Celf_1965Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (395 aa)
mqoTIGRFAM: malate/quinone oxidoreductase; KEGG: malate/quinone oxidoreductase; PFAM: Malate:quinone-oxidoreductase. (516 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (513 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa)
Celf_1593D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (418 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (333 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (387 aa)
Celf_1441KEGG: F420-dependent oxidoreductase, G6PDH family; TIGRFAM: F420-dependent oxidoreductase, G6PDH family; PFAM: Luciferase-like, subgroup. (337 aa)
Celf_1311KEGG: flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase; TIGRFAM: putative F420-dependent oxidoreductase; PFAM: Luciferase-like, subgroup. (290 aa)
Celf_1299PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: tcu:Tcur_1996 glucose-methanol-choline oxidoreductase. (814 aa)
Celf_1246PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: theronine dehydrogenase-like Zn-dependent dehydrogenase. (397 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (330 aa)
Celf_1122TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
Celf_1076KEGG: IMP dehydrogenase family protein; TIGRFAM: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase/GMP reductase. (374 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (504 aa)
Celf_1050KEGG: putative F420-dependent oxidoreductase; TIGRFAM: putative F420-dependent oxidoreductase; PFAM: Luciferase-like, subgroup. (328 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase domain-containing protein; Cell wall formation. (374 aa)
Celf_0003KEGG: 6-phosphogluconate dehydrogenase, decarboxylating; TIGRFAM: 6-phosphogluconate dehydrogenase, decarboxylating; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; 6-phosphogluconate dehydrogenase domain-containing protein. (315 aa)
Celf_0079PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; KEGG: fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (572 aa)
Celf_0150PFAM: Luciferase-like, subgroup; KEGG: luciferase-like, subgroup. (279 aa)
Celf_0377PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: lxx:Lxx23600 alcohol dehydrogenase. (357 aa)
Celf_0456PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: kfl:Kfla_1534 alcohol dehydrogenase zinc-binding domain protein. (340 aa)
Celf_0481PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: oxidoreductase domain protein. (334 aa)
Celf_0603KEGG: FAD-linked oxidoreductase; TIGRFAM: FAD-linked oxidoreductase; PFAM: D-arabinono-14-lactone oxidase; FAD linked oxidase domain protein. (455 aa)
Celf_0730TIGRFAM: nucleotide sugar dehydrogenase; KEGG: kra:Krad_3900 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase. (441 aa)
Celf_0835PFAM: malic protein NAD-binding; malic protein domain protein; amino acid-binding ACT domain protein; KEGG: malate dehydrogenase (oxaloacetate-decarboxylating). (466 aa)
Celf_0857PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: cai:Caci_3810 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding. (338 aa)
Your Current Organism:
Cellulomonas fimi
NCBI taxonomy Id: 590998
Other names: C. fimi ATCC 484, Cellulomonas fimi ATCC 484, Cellulomonas fimi DSM 20113, Cellulomonas fimi str. ATCC 484, Cellulomonas fimi strain ATCC 484
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