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Celf_0097 Celf_0097 Celf_0142 Celf_0142 Celf_0170 Celf_0170 Celf_0171 Celf_0171 topA topA Celf_0483 Celf_0483 Celf_0509 Celf_0509 cas1 cas1 Celf_0535 Celf_0535 ung ung Celf_0652 Celf_0652 Celf_0750 Celf_0750 Celf_0784 Celf_0784 Celf_0800 Celf_0800 Celf_0831 Celf_0831 Celf_1107 Celf_1107 Celf_1138 Celf_1138 Celf_1145 Celf_1145 Celf_1149 Celf_1149 Celf_1165 Celf_1165 Celf_1166 Celf_1166 Celf_1171 Celf_1171 Celf_1185 Celf_1185 Celf_1234 Celf_1234 Celf_1325 Celf_1325 Celf_1390 Celf_1390 Celf_1526 Celf_1526 Celf_1556 Celf_1556 Celf_1563 Celf_1563 recA recA Celf_1584 Celf_1584 Celf_1594 Celf_1594 dinB dinB Celf_1627 Celf_1627 Celf_1670 Celf_1670 Celf_1737 Celf_1737 dnaE2 dnaE2 lig lig polA polA uvrB uvrB uvrC uvrC Celf_3766 Celf_3766 Celf_3718 Celf_3718 Celf_3694 Celf_3694 Celf_3664 Celf_3664 Celf_3534 Celf_3534 Celf_3528 Celf_3528 Celf_3513 Celf_3513 radA radA Celf_3478 Celf_3478 Celf_3477 Celf_3477 Celf_3459 Celf_3459 Celf_3431 Celf_3431 Celf_3424 Celf_3424 Celf_3419 Celf_3419 nth nth Celf_3350 Celf_3350 Celf_3315 Celf_3315 Celf_3178 Celf_3178 Celf_3144 Celf_3144 Celf_3142 Celf_3142 Celf_3135 Celf_3135 Celf_2970 Celf_2970 xseB xseB xseA xseA nucS nucS ligA ligA dinB-2 dinB-2 Celf_2588 Celf_2588 recD recD recB recB recC recC Celf_2479 Celf_2479 Celf_2468 Celf_2468 Celf_2445 Celf_2445 mutM mutM Celf_2402 Celf_2402 Celf_2275 Celf_2275 Celf_2247 Celf_2247 Celf_2178 Celf_2178 Celf_2160 Celf_2160 Celf_2157 Celf_2157 Celf_2146 Celf_2146 Celf_2108 Celf_2108 ruvC ruvC ruvA ruvA ruvB ruvB Celf_1942 Celf_1942 Celf_1919 Celf_1919 Celf_1917 Celf_1917 xerC xerC Celf_0002 Celf_0002 gyrB gyrB gyrA gyrA Celf_0041 Celf_0041 Celf_0042 Celf_0042 Celf_0053 Celf_0053
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Celf_0097KEGG: hypothetical protein. (327 aa)
Celf_0142KEGG: cwo:Cwoe_0405 hypothetical protein. (390 aa)
Celf_0170PFAM: transposase IS3/IS911 family protein; KEGG: mmi:MMAR_4592 transposase. (94 aa)
Celf_0171PFAM: Integrase catalytic region; KEGG: kse:Ksed_20160 transposase. (293 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (916 aa)
Celf_0483SMART: AAA ATPase; KEGG: DNA polymerase III, delta prime subunit. (378 aa)
Celf_0509KEGG: DNA polymerase LigD, polymerase domain protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: DNA primase small subunit. (356 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (317 aa)
Celf_0535KEGG: 5'-3' exonuclease, N-terminal resolvase-like domain protein; PFAM: 5'-3' exonuclease, N-terminal resolvase-like domain; 5'-3' exonuclease, SAM-fold domain; SMART: 5'-3' exonuclease; Helix-hairpin-helix domain protein class 2. (318 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (225 aa)
Celf_0652KEGG: helicase domain protein; PFAM: helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicase; helicase domain protein. (548 aa)
Celf_0750PFAM: N-6 DNA methylase; KEGG: aat:D11S_1858 putative N-6 DNA methylase. (633 aa)
Celf_0784PFAM: protein of unknown function DUF1006; KEGG: nca:Noca_2334 hypothetical protein. (369 aa)
Celf_0800KEGG: svi:Svir_34920 DNA ligase D/DNA polymerase LigD; TIGRFAM: DNA polymerase LigD, ligase domain protein; DNA ligase D, 3'-phosphoesterase domain protein; PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein. (491 aa)
Celf_0831KEGG: hypothetical protein. (264 aa)
Celf_1107KEGG: ATP-dependent DNA helicase PcrA; TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase. (852 aa)
Celf_1138KEGG: exodeoxyribonuclease III Xth; TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase. (277 aa)
Celf_1145KEGG: hypothetical protein. (320 aa)
Celf_1149KEGG: xce:Xcel_3159 hypothetical protein. (308 aa)
Celf_1165PFAM: UvrD/REP helicase; KEGG: UvrD/REP helicase. (1077 aa)
Celf_1166PFAM: UvrD/REP helicase; KEGG: UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily. (1166 aa)
Celf_1171KEGG: UvrD/REP helicase; PFAM: UvrD/REP helicase; HRDC domain protein; SMART: HRDC domain protein. (686 aa)
Celf_1185PFAM: DNA primase small subunit; KEGG: DNA ligase D, 3'-phosphoesterase domain protein. (317 aa)
Celf_1234KEGG: AlkA domain protein; PFAM: HhH-GPD family protein; AlkA domain protein; SMART: HhH-GPD family protein. (278 aa)
Celf_1325KEGG: 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase-like protein. (332 aa)
Celf_1390KEGG: putative viral-like DNA topoisomerase. (333 aa)
Celf_1526KEGG: DNA-formamidopyrimidine glycosylase; PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein. (296 aa)
Celf_1556KEGG: hypothetical protein. (377 aa)
Celf_1563PFAM: Formamidopyrimidine-DNA glycosylase catalytic domain protein; DNA glycosylase/AP lyase, H2TH DNA-binding; KEGG: DNA-(apurinic or apyrimidinic site) lyase. (258 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (346 aa)
Celf_1584SMART: helicase c2; DEAD-like helicase; KEGG: helicase C2. (701 aa)
Celf_1594KEGG: UvrD/REP helicase. (750 aa)
dinBDNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (423 aa)
Celf_1627DNA polymerase III, alpha subunit; SMART: phosphoesterase PHP domain protein; TIGRFAM: DNA polymerase III, alpha subunit; KEGG: DNA polymerase III, alpha subunit; PFAM: DNA polymerase III alpha subunit; PHP domain protein; nucleic acid binding OB-fold tRNA/helicase-type. (1179 aa)
Celf_1670KEGG: DNA-3-methyladenine glycosylase; TIGRFAM: DNA-3-methyladenine glycosylase; PFAM: methylpurine-DNA glycosylase (MPG); Belongs to the DNA glycosylase MPG family. (233 aa)
Celf_1737KEGG: hypothetical protein. (658 aa)
dnaE2DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1192 aa)
ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (510 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (915 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (701 aa)
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (698 aa)
Celf_3766KEGG: sth:STH1435 site-specific DNA-methyltransferase; PFAM: D12 class N6 adenine-specific DNA methyltransferase. (345 aa)
Celf_3718KEGG: DNA-3-methyladenine glycosylase I; PFAM: methyladenine glycosylase. (228 aa)
Celf_3694PFAM: Uracil-DNA glycosylase superfamily; KEGG: uracil-DNA glycosylase superfamily. (257 aa)
Celf_3664PFAM: Resolvase domain; Resolvase helix-turn-helix domain protein; KEGG: nml:Namu_3655 resolvase domain protein. (196 aa)
Celf_3534KEGG: kra:Krad_1521 phage SPO1 DNA polymerase-related protein; TIGRFAM: phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase superfamily. (210 aa)
Celf_3528KEGG: exodeoxyribonuclease III Xth; TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase. (263 aa)
Celf_3513KEGG: HhH-GPD family protein; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; SMART: HhH-GPD family protein; iron-sulfur cluster loop. (302 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (475 aa)
Celf_3478PFAM: Integrase catalytic region; KEGG: kse:Ksed_20160 transposase. (293 aa)
Celf_3477PFAM: transposase IS3/IS911 family protein; KEGG: mmi:MMAR_4592 transposase. (94 aa)
Celf_3459PFAM: DNA glycosylase/AP lyase, H2TH DNA-binding; Formamidopyrimidine-DNA glycosylase catalytic domain protein; KEGG: DNA glycosylase/AP lyase, H2TH DNA-binding protein; Belongs to the FPG family. (308 aa)
Celf_3431PFAM: NERD domain protein; KEGG: fal:FRAAL5365 hypothetical protein. (307 aa)
Celf_3424SMART: AAA ATPase; KEGG: AAA ATPase. (240 aa)
Celf_3419TIGRFAM: DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase central domain protein; KEGG: DNA polymerase III, subunits gamma and tau; SMART: AAA ATPase. (901 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (231 aa)
Celf_3350KEGG: kra:Krad_0193 hypothetical protein. (319 aa)
Celf_3315KEGG: DNA-directed DNA polymerase; PFAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase. (567 aa)
Celf_3178KEGG: DNA binding domain protein, excisionase family; TIGRFAM: DNA binding domain protein, excisionase family; PFAM: regulatory protein MerR. (70 aa)
Celf_3144KEGG: kse:Ksed_06440 TrwC relaxase; TIGRFAM: conjugative relaxase domain protein; PFAM: TrwC relaxase. (963 aa)
Celf_3142Hypothetical protein; Manually curated; KEGG: dol:Dole_3086 hypothetical protein. (1050 aa)
Celf_3135KEGG: helicase domain protein; PFAM: helicase domain protein; SNF2-related protein; SMART: DEAD-like helicase; helicase domain protein. (720 aa)
Celf_2970PFAM: transposase IS3/IS911 family protein; KEGG: kra:Krad_2458 transposase IS3/IS911 family protein. (256 aa)
xseBExodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (101 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (415 aa)
nucSProtein of unknown function DUF91; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (231 aa)
ligADNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (834 aa)
dinB-2DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (409 aa)
Celf_2588PFAM: ATP dependent DNA ligase; ATP dependent DNA ligase domain protein; KEGG: ATP dependent DNA ligase. (353 aa)
recDExodeoxyribonuclease V, alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (644 aa)
recBExodeoxyribonuclease V; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzy [...] (1216 aa)
recCExodeoxyribonuclease V, gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...] (1138 aa)
Celf_2479KEGG: sen:SACE_0696 hypothetical protein. (394 aa)
Celf_2468PFAM: protein of unknown function DUF1006; KEGG: hypothetical protein. (425 aa)
Celf_2445KEGG: DEAD/DEAH box helicase domain protein; PFAM: DEAD/DEAH box helicase domain protein; nucleic acid binding OB-fold tRNA/helicase-type; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein. (750 aa)
mutMformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (302 aa)
Celf_2402KEGG: aau:AAur_3642 DNA polymerase IV; PFAM: UMUC domain protein DNA-repair protein. (358 aa)
Celf_2275KEGG: DNA binding domain protein, excisionase family; TIGRFAM: DNA binding domain protein, excisionase family; PFAM: regulatory protein MerR. (74 aa)
Celf_2247KEGG: kfl:Kfla_7038 hypothetical protein. (304 aa)
Celf_2178DNA polymerase III, epsilon subunit; SMART: Exonuclease; Excinuclease ABC C subunit domain protein; TIGRFAM: DNA polymerase III, epsilon subunit; KEGG: DNA polymerase III, epsilon subunit; PFAM: Exonuclease RNase T and DNA polymerase III; Excinuclease ABC C subunit domain protein. (620 aa)
Celf_2160PFAM: DNA gyrase subunit B domain protein; DNA topoisomerase type IIA subunit B region 2 domain protein; ATP-binding region ATPase domain protein; TOPRIM domain-containing protein; KEGG: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase II; ATP-binding region ATPase domain protein. (712 aa)
Celf_2157PFAM: DNA gyrase/topoisomerase IV subunit A; DNA gyrase repeat beta-propeller; KEGG: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA gyrase/topoisomerase IV subunit A. (824 aa)
Celf_2146PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: nucleic acid binding OB-fold tRNA/helicase-type. (122 aa)
Celf_2108KEGG: apurinic endonuclease Apn1; PFAM: Xylose isomerase domain-containing protein TIM barrel; SMART: AP endonuclease family 2. (253 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (188 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (204 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (355 aa)
Celf_1942PFAM: integrase family protein; KEGG: tcu:Tcur_2383 integrase family protein; Belongs to the 'phage' integrase family. (340 aa)
Celf_1919KEGG: PHP domain protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein. (362 aa)
Celf_1917KEGG: xce:Xcel_2233 DNA polymerase LigD, polymerase domain protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; PFAM: DNA primase small subunit. (293 aa)
xerCIntegrase family protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (322 aa)
Celf_0002DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (682 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (870 aa)
Celf_0041KEGG: nca:Noca_1589 Eco57I restriction endonuclease. (350 aa)
Celf_0042KEGG: bcv:Bcav_1494 hypothetical protein. (365 aa)
Celf_0053Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (459 aa)
Your Current Organism:
Cellulomonas fimi
NCBI taxonomy Id: 590998
Other names: C. fimi ATCC 484, Cellulomonas fimi ATCC 484, Cellulomonas fimi DSM 20113, Cellulomonas fimi str. ATCC 484, Cellulomonas fimi strain ATCC 484
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