STRINGSTRING
ADI31155.1 ADI31155.1 fen fen priS priS pcn pcn priL priL ADI31674.1 ADI31674.1 ADI31767.1 ADI31767.1 ADI31768.1 ADI31768.1 ADI31858.1 ADI31858.1 ADI31859.1 ADI31859.1 ADI31860.1 ADI31860.1 ADI31861.1 ADI31861.1 ADI31862.1 ADI31862.1 ADI31902.1 ADI31902.1 ADI32133.1 ADI32133.1 pcn-2 pcn-2 lig lig topA topA ADI32328.1 ADI32328.1 rfcS rfcS rfcL rfcL ADI32333.1 ADI32333.1 pcn-3 pcn-3 radA radA ADI32603.1 ADI32603.1 ADI32604.1 ADI32604.1 ADI32668.1 ADI32668.1 ADI32684.1 ADI32684.1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADI31155.1PFAM: protein of unknown function DUF99; KEGG: tgr:Tgr7_2677 protein of unknown function DUF99; Belongs to the UPF0215 family. (191 aa)
fenFlap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] (350 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (377 aa)
pcnProliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (248 aa)
priLDNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (376 aa)
ADI31674.1DNA polymerase B region; KEGG: hypothetical protein; K02320 DNA polymerase alpha subunit A; PFAM: DNA polymerase B region; SMART: DNA-directed DNA polymerase B. (648 aa)
ADI31767.1PFAM: ERCC4 domain protein; helix-hairpin-helix motif; KEGG: sbn:Sbal195_0376 ERCC4 domain-containing protein. (234 aa)
ADI31768.1UDP-N-acetylglucosamine--dolichyl-phosphateN- acetylglucosaminephosphotransferase; KEGG: N-acetylglucosamine-1-phosphate transferase; K01001 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphstransferase; PFAM: Glycosyl transferase, family 4, conserved region. (344 aa)
ADI31858.1Hypothetical protein. (309 aa)
ADI31859.1PFAM: SMC domain protein; KEGG: viral A-type inclusion protein. (832 aa)
ADI31860.1KEGG: pfs:PFLU0171 hypothetical protein. (673 aa)
ADI31861.1Hypothetical protein. (445 aa)
ADI31862.1PFAM: metallophosphoesterase; KEGG: gme:Gmet_1223 metallophosphoesterase. (423 aa)
ADI31902.1PFAM: Beta propeller domain; KEGG: hypothetical protein. (707 aa)
ADI32133.1PFAM: nucleic acid binding OB-fold tRNA/helicase-type; KEGG: similar to oligonucleotide/oligosaccharide-binding fold containing 2B. (151 aa)
pcn-2Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (245 aa)
ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (611 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (723 aa)
ADI32328.1MCM family protein; KEGG: hypothetical protein; K02540 minichromosome maintenance protein 2; PFAM: MCM family protein; SMART: MCM family protein; Hedgehog/intein hint domain protein; Belongs to the MCM family. (1049 aa)
rfcSReplication factor C; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (329 aa)
rfcLAAA ATPase central domain protein; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (423 aa)
ADI32333.1Orc1/cdc6 family replication initiation protein; Involved in regulation of DNA replication. (428 aa)
pcn-3Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. (252 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (319 aa)
ADI32603.1KEGG: gsu:GSU1952 hypothetical protein. (334 aa)
ADI32604.1PFAM: glycosyl transferase group 1; KEGG: GJ13737 gene product from transcript GJ13737-RA. (384 aa)
ADI32668.1SMART: DNA-directed DNA polymerase B; TIGRFAM: DNA polymerase Pol2; KEGG: pold1; polymerase (DNA directed), delta 1, catalytic subunit 125kDa; K02327 DNA polymerase delta subunit 1; PFAM: DNA polymerase B region; DNA polymerase B exonuclease. (801 aa)
ADI32684.1PFAM: DNA polymerase B region; DNA polymerase B exonuclease; KEGG: hypothetical protein; K02320 DNA polymerase alpha subunit A; SMART: DNA-directed DNA polymerase B. (855 aa)
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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