STRINGSTRING
ADI32593.1 ADI32593.1 adk adk ADI31517.1 ADI31517.1 ADI31490.1 ADI31490.1 ADI31482.1 ADI31482.1 ADI31481.1 ADI31481.1 ADI31479.1 ADI31479.1 ADI31473.1 ADI31473.1 ADI31362.1 ADI31362.1 pyrG pyrG ADI31360.1 ADI31360.1 pyrE pyrE pyrB pyrB pyrI pyrI ADI31356.1 ADI31356.1 ADI31355.1 ADI31355.1 pyrD pyrD carS carS tmk tmk nadK nadK ADI31191.1 ADI31191.1 guaA guaA ADI31184.1 ADI31184.1 purA purA ADI31181.1 ADI31181.1 pyrH pyrH ADI31160.1 ADI31160.1 ADI31643.1 ADI31643.1 ADI31648.1 ADI31648.1 ADI31655.1 ADI31655.1 ADI31705.1 ADI31705.1 mvk mvk ADI31771.1 ADI31771.1 ADI31797.1 ADI31797.1 ADI31813.1 ADI31813.1 ADI31844.1 ADI31844.1 thi4 thi4 ADI31925.1 ADI31925.1 moaC moaC ADI31932.1 ADI31932.1 ADI31944.1 ADI31944.1 ADI31953.1 ADI31953.1 ADI32023.1 ADI32023.1 ADI32061.1 ADI32061.1 ADI32093.1 ADI32093.1 ADI32094.1 ADI32094.1 ADI32102.1 ADI32102.1 ADI32106.1 ADI32106.1 ADI32107.1 ADI32107.1 ADI32110.1 ADI32110.1 ADI32170.1 ADI32170.1 panB panB ADI32172.1 ADI32172.1 ADI32173.1 ADI32173.1 ADI32174.1 ADI32174.1 nadE nadE ADI32300.1 ADI32300.1 prs prs ADI32363.1 ADI32363.1 ADI32370.1 ADI32370.1 ADI32377.1 ADI32377.1 atpD atpD atpE atpE ADI32392.1 ADI32392.1 atpA atpA atpB atpB ADI32396.1 ADI32396.1 ADI32409.1 ADI32409.1 ADI32418.1 ADI32418.1 ADI32446.1 ADI32446.1 mptE mptE ADI32462.1 ADI32462.1 ADI32464.1 ADI32464.1 thyX thyX dcd dcd cmk cmk ADI32549.1 ADI32549.1 ADI32550.1 ADI32550.1 ndk ndk ADI32717.1 ADI32717.1 ADI32617.1 ADI32617.1 egsA egsA ADI32556.1 ADI32556.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ADI32593.1PFAM: phosphoribosyltransferase; KEGG: hdu:HD1818 adenine phosphoribosyltransferase. (269 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (226 aa)
ADI31517.1PFAM: thiamineS protein; KEGG: bmi:BMEA_A0733 molybdopterin converting factor, subunit 1. (88 aa)
ADI31490.1PFAM: Thiamine biosynthesis protein-like; Queuosine synthesis-like; KEGG: bpn:BPEN_246 thiamine biosynthesis protein ThiI. (375 aa)
ADI31482.1PFAM: molybdopterin biosynthesis MoaE protein; KEGG: psp:PSPPH_1124 molybdopterin converting factor, subunit 2. (154 aa)
ADI31481.1TIGRFAM: MoaD family protein; PFAM: thiamineS protein. (83 aa)
ADI31479.1PFAM: Quinolinate phosphoribosyl transferase; KEGG: ilo:IL0103 nicotinate phosphoribosyltransferase. (391 aa)
ADI31473.1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (289 aa)
ADI31362.1PFAM: phosphoribosyltransferase; KEGG: mca:MCA2827 phosphoribosyl transferase domain-containing protein. (189 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa)
ADI31360.1KEGG: wpi:WPa_0101 orotidine 5`-phosphate decarboxylase; TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase. (230 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (203 aa)
pyrBKEGG: aspartate carabmoyltransferase, chloroplast / aspartate transcarbamylase / ATCase (PYRB); K00609 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region. (311 aa)
pyrIAspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (156 aa)
ADI31356.1PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; oxidoreductase FAD/NAD(P)-binding domain protein; KEGG: sat:SYN_02220 oxidoreductase. (258 aa)
ADI31355.1PFAM: amidohydrolase; KEGG: dal:Dalk_1370 dihydroorotase, multifunctional complex type. (434 aa)
pyrDDihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate. (301 aa)
carSProtein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (172 aa)
tmkTIGRFAM: thymidylate kinase; KEGG: scl:sce0834 putative thymidylate kinase; PFAM: thymidylate kinase. (199 aa)
nadKATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (275 aa)
ADI31191.1PFAM: phosphoribosyltransferase; KEGG: tgr:Tgr7_1686 phosphoribosyltransferase. (232 aa)
guaAGMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (529 aa)
ADI31184.1PFAM: phosphoribosyltransferase; KEGG: sat:SYN_03353 xanthine-guanine phosphoribosyltransferase. (205 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (339 aa)
ADI31181.1KEGG: erg:ERGA_CDS_02460 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase-like; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (460 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (224 aa)
ADI31160.1Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (194 aa)
ADI31643.1KEGG: mxa:MXAN_2759 molybdenum cofactor biosynthesis protein B; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain. (161 aa)
ADI31648.1PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase GAPDH domain protein; KEGG: pay:PAU_02396 hypothetical protein. (381 aa)
ADI31655.1KEGG: gur:Gura_2134 indolepyruvate oxidoreductase subunit beta; PFAM: Pyruvate/ketoisovalerate oxidoreductase. (200 aa)
ADI31705.1KEGG: dihydroorotate dehydrogenase family protein; TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate oxidase; 4Fe-4S ferredoxin iron-sulfur binding domain protein. (406 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (318 aa)
ADI31771.1KEGG: cti:RALTA_B1432 uracil phosphoribosyltransferase; PFAM: phosphoribosyltransferase. (218 aa)
ADI31797.1KEGG: ppd:Ppro_0567 hypothetical protein. (457 aa)
ADI31813.1PFAM: amidohydrolase; KEGG: D-hydantoinase; K01465 dihydroorotase. (447 aa)
ADI31844.1KEGG: dol:Dole_3175 molybdopterin-guanine dinucleotide biosynthesis protein A. (223 aa)
thi4Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (275 aa)
ADI31925.1PFAM: MoeA domain protein domain I and II; molybdopterin binding domain; KEGG: gem:GM21_2072 molybdenum cofactor synthesis domain protein. (427 aa)
moaCMolybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (144 aa)
ADI31932.1Radical SAM domain protein; KEGG: shl:Shal_0144 molybdenum cofactor biosynthesis protein A; PFAM: Radical SAM domain protein; molybdenum cofactor synthesis domain protein; SMART: Elongator protein 3/MiaB/NifB. (316 aa)
ADI31944.1KEGG: dal:Dalk_4696 molybdenum cofactor synthesis domain protein; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: MoeA domain protein domain I and II; MoeA domain protein domain IV; molybdopterin binding domain. (415 aa)
ADI31953.1Hypothetical protein. (210 aa)
ADI32023.1PFAM: beta-lactamase domain protein; KEGG: dat:HRM2_43600 putative metal-dependent hydrolase. (305 aa)
ADI32061.1TIGRFAM: cytidyltransferase-related domain protein; KEGG: dac:Daci_5608 cytidyltransferase-like protein; PFAM: cytidylyltransferase. (184 aa)
ADI32093.1KEGG: hha:Hhal_1602 geranylgeranyl reductase; TIGRFAM: geranylgeranyl reductase; PFAM: FAD dependent oxidoreductase; monooxygenase FAD-binding. (458 aa)
ADI32094.1PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; KEGG: sdn:Sden_0212 molybdopterin-guanine dinucleotide biosynthesis protein B. (267 aa)
ADI32102.1Dehydrogenase (flavoprotein)-like protein; KEGG: hypothetical protein. (373 aa)
ADI32106.1KEGG: sfu:Sfum_2793 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein. (96 aa)
ADI32107.1KEGG: sfu:Sfum_2792 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase. (191 aa)
ADI32110.1PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Pyruvate/ketoisovalerate oxidoreductase; KEGG: dvm:DvMF_0184 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (593 aa)
ADI32170.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (307 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa)
ADI32172.1Kinase (sugar kinase superfamily)-like protein. (280 aa)
ADI32173.1PFAM: Protein of unknown function DUF137. (259 aa)
ADI32174.1KEGG: sat:SYN_02177 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein. (410 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa)
ADI32300.1Protein of unknown function DUF265; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (185 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (305 aa)
ADI32363.1PFAM: protein of unknown function DUF120; KEGG: geo:Geob_0130 HAD-superfamily hydrolase, subfamily IA, variant 3. (130 aa)
ADI32370.1Adenylyl cyclase CyaB; KEGG: dal:Dalk_3154 adenylate cyclase; TIGRFAM: adenylyl cyclase CyaB; PFAM: adenylate cyclase. (189 aa)
ADI32377.1PFAM: CDP-alcohol phosphatidyltransferase; KEGG: sfu:Sfum_3077 CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (191 aa)
atpDV-type ATPase, D subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (208 aa)
atpEH+transporting two-sector ATPase E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (196 aa)
ADI32392.1Hypothetical protein. (108 aa)
atpAH(+)-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (592 aa)
atpBH(+)-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (469 aa)
ADI32396.1PFAM: beta-lactamase domain protein; KEGG: dat:HRM2_43600 putative metal-dependent hydrolase. (236 aa)
ADI32409.1PFAM: UbiA prenyltransferase; KEGG: chlorophyll a synthase; K04040 chlorophyll synthase. (282 aa)
ADI32418.1PFAM: beta-lactamase domain protein; KEGG: dat:HRM2_43600 putative metal-dependent hydrolase. (237 aa)
ADI32446.1PFAM: ATP-NAD/AcoX kinase; KEGG: sfr:Sfri_2665 ATP-NAD/AcoX kinase. (364 aa)
mptEProtein of unknown function DUF115; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP). (261 aa)
ADI32462.1PFAM: flavoprotein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: mfa:Mfla_1582 flavoprotein. (253 aa)
ADI32464.1PFAM: protein of unknown function DUF198; KEGG: gbm:Gbem_3692 protein of unknown function DUF198. (283 aa)
thyXThymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (324 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (179 aa)
cmkCytidylate kinase; KEGG: gem:GM21_1911 transport-associated protein; TIGRFAM: cytidylate kinase. (177 aa)
ADI32549.1TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; KEGG: sfu:Sfum_0543 pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate/ketoisovalerate oxidoreductase. (203 aa)
ADI32550.1KEGG: sat:SYN_00694 pyruvate synthase delta subunit; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein. (93 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (141 aa)
ADI32717.1Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (160 aa)
ADI32617.1TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-related domain protein; KEGG: hch:HCH_06993 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; PFAM: cytidylyltransferase. (175 aa)
egsA3-dehydroquinate synthase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. (354 aa)
ADI32556.1Geranylgeranylglyceryl phosphate synthase family protein; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (245 aa)
Your Current Organism:
Staphylothermus hellenicus
NCBI taxonomy Id: 591019
Other names: S. hellenicus DSM 12710, Staphylothermus hellenicus BK20S6-10-b1, Staphylothermus hellenicus DSM 12710, Staphylothermus hellenicus P8, Staphylothermus hellenicus str. DSM 12710, Staphylothermus hellenicus strain DSM 12710, Staphylothermus sp. P8
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