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flgN flgN flgM flgM flgA flgA flgB flgB flgC flgC flgD flgD flgE flgE flgF flgF flgG flgG flgH flgH flgI flgI flgJ flgJ flgK flgK flgL flgL flhA flhA flhB flhB motB motB motA motA flhC flhC flhD flhD fliZ fliZ fliA fliA ANA30103.1 ANA30103.1 fliD fliD fliS fliS fliE fliE fliF fliF fliG fliG fliH fliH fliI fliI fliJ fliJ ANA30118.1 ANA30118.1 fliL fliL fliM fliM fliN fliN fliO fliO fliP fliP fliQ fliQ fliR fliR ANA30724.1 ANA30724.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
flgNFlagellar biosynthesis protein FlgN; Export chaperone for FlgK and FlgL; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
flgMNegative regulator of flagellin synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
flgAFlagellar basal body P-ring biosynthesis protein FlgA; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (219 aa)
flgBHypothetical protein; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (138 aa)
flgCWith FlgF and B makes up the proximal portion of the flagellar basal body rod; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
flgDFlagellar basal body rod modification protein; Required for flagellar hook formation. May act as a scaffolding protein. (232 aa)
flgEThe hook connects flagellar basal body to the flagellar filament; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
flgFFlagellar basal body rod protein FlgF; FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
flgGMakes up the distal portion of the flagellar basal body rod; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
flgHFlagellar basal body L-ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (232 aa)
flgIFlagellar basal body P-ring biosynthesis protein FlgA; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (365 aa)
flgJFlagellar rod assembly protein FlgJ; Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
flgKWith FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
flgLWith FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
flhAFlagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (692 aa)
flhBFlagellar biosynthesis protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (383 aa)
motBFlagellar motor protein MotB; With MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
motAFlagellar motor protein MotA; With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
flhCTranscriptional regulator; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (192 aa)
flhDTranscriptional regulator; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (113 aa)
fliZFlagella biosynthesis protein FliZ; Expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
fliAFlagellar biosynthesis sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa)
ANA30103.1Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (493 aa)
fliDFlagellar protein FliD; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (468 aa)
fliSFlagellar protein FliS; Flagellin specific chaperone; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
fliEFlagellar hook-basal body protein FliE; Forms a junction between the M-ring and FlgB during flagella biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (104 aa)
fliFHypothetical protein; The M ring may be actively involved in energy transduction. Belongs to the FliF family. (560 aa)
fliGFlagellar motor switch protein G; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (331 aa)
fliHFlagellar assembly protein H; Binds to and inhibits the function of flagella specific ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
fliIATP synthase; Involved in type III protein export during flagellum assembly; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
fliJFlagellar biosynthesis chaperone; Flagellar protein that affects chemotactic events. Belongs to the FliJ family. (147 aa)
ANA30118.1Flagellar hook-length control protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
fliLFlagellar basal body-associated protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family. (155 aa)
fliMFlagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (334 aa)
fliNFlagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (137 aa)
fliOFlagellar biosynthesis protein FliO; With FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
fliPFlagellar biosynthesis protein flip; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (245 aa)
fliQFlagellar biosynthesis protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliRFlagellar biosynthesis protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (264 aa)
ANA30724.1Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (499 aa)
Your Current Organism:
Salmonella enterica diarizonae
NCBI taxonomy Id: 59204
Other names: ATCC 43973, CCUG 30040, CIP 82.31, DSM 14847, NCTC 10060, S. enterica subsp. diarizonae, Salmonella cholerae-suis subsp. diarizonae, Salmonella choleraesuis subsp. diarizonae, Salmonella enterica IIIb, Salmonella enterica serovar IIIb, Salmonella enterica subsp. IIIb, Salmonella enterica subsp. Subsp. IIIb, Salmonella enterica subsp. diarizonae
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