STRINGSTRING
ilvH ilvH acnB acnB ANA28800.1 ANA28800.1 ANA28825.1 ANA28825.1 gltA gltA ANA28969.1 ANA28969.1 aspC aspC icdA icdA ANA29725.1 ANA29725.1 acnA acnA ANA30146.1 ANA30146.1 ANA30276.1 ANA30276.1 ANA30341.1 ANA30341.1 ANA30440.1 ANA30440.1 ANA30478.1 ANA30478.1 ANA30483.1 ANA30483.1 ptsJ ptsJ ypeA ypeA gabR_1 gabR_1 argA argA ANA31764.1 ANA31764.1 sfsB sfsB argD argD asd asd yvoA yvoA ANA27644.1 ANA27644.1 ilvB ilvB ilvG ilvG ilvM ilvM ilvE ilvE ilvD ilvD ilvC ilvC ANA27823.1 ANA27823.1 argC argC argE argE argB argB ANA27943.1 ANA27943.1 fxsA fxsA ANA28174.1 ANA28174.1 ANA31618.1 ANA31618.1 leuD leuD leuC leuC leuB leuB leuA leuA ANA28411.1 ANA28411.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ilvHAcetolactate synthase 3 regulatory subunit; With IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
acnBBifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (865 aa)
ANA28800.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
ANA28825.1Methionine aminotransferase; Catalyzes the transfer of an amino moiety; preference for methionine followed by histidine and phenylalanine; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (427 aa)
ANA28969.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
aspCAromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
icdAConverts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
ANA29725.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (891 aa)
ANA30146.1Molybdenum cofactor biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (717 aa)
ANA30276.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
ANA30341.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa)
ANA30440.1Aminotransferase; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
ANA30478.1Semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa)
ANA30483.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (82 aa)
ptsJRegulator of the ptsHI/crr operon; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
ypeAAcetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. YpeA subfamily. (141 aa)
gabR_1DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
argAN-acetylglutamate synthase; Catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily. (443 aa)
ANA31764.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
sfsBTranscriptional regulator; Activator of maltose metabolism genes; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
argDAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (405 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa)
yvoAGntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
ANA27644.1Acetolactate synthase 1 regulatory subunit; With IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (96 aa)
ilvBAcetolactate synthase catalytic subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (562 aa)
ilvGAcetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)
ilvMAcetolactate synthase 2 regulatory subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (87 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (616 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (491 aa)
ANA27823.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa)
argEAcetylornithine deacetylase; Catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate. (257 aa)
ANA27943.1Aspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (449 aa)
fxsAF exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (158 aa)
ANA28174.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
ANA31618.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (466 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (363 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (523 aa)
ANA28411.1Acetolactate synthase 3 catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology. (574 aa)
Your Current Organism:
Salmonella enterica diarizonae
NCBI taxonomy Id: 59204
Other names: ATCC 43973, CCUG 30040, CIP 82.31, DSM 14847, NCTC 10060, S. enterica subsp. diarizonae, Salmonella cholerae-suis subsp. diarizonae, Salmonella choleraesuis subsp. diarizonae, Salmonella enterica IIIb, Salmonella enterica serovar IIIb, Salmonella enterica subsp. IIIb, Salmonella enterica subsp. Subsp. IIIb, Salmonella enterica subsp. diarizonae
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