STRINGSTRING
ompA_3 ompA_3 yiaD yiaD ANA30838.1 ANA30838.1 spaS spaS ANA30724.1 ANA30724.1 fliR fliR fliQ fliQ fliP fliP fliO fliO fliN fliN fliM fliM ANA30118.1 ANA30118.1 fliJ fliJ fliI fliI fliH fliH fliG fliG fliF fliF fliE fliE fliT fliT fliS fliS fliD fliD ANA30103.1 ANA30103.1 fliA fliA flhD flhD flhC flhC motA motA motB motB flhB flhB flhA flhA osmB osmB ANA29661.1 ANA29661.1 ssaK ssaK flgL flgL flgK flgK flgI flgI flgH flgH flgG flgG flgF flgF flgE flgE flgD flgD flgC flgC flgB flgB flgA flgA flgM flgM flgN flgN ANA31670.1 ANA31670.1 pal pal
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ompA_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (318 aa)
yiaDMembrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
ANA30838.1ATP synthase; Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells; probable catalytic subunit of a protein translocase; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
spaSType III secretion system protein SpaS; Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
ANA30724.1Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (499 aa)
fliRFlagellar biosynthesis protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (264 aa)
fliQFlagellar biosynthesis protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
fliPFlagellar biosynthesis protein flip; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (245 aa)
fliOFlagellar biosynthesis protein FliO; With FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
fliNFlagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family. (137 aa)
fliMFlagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (334 aa)
ANA30118.1Flagellar hook-length control protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
fliJFlagellar biosynthesis chaperone; Flagellar protein that affects chemotactic events. Belongs to the FliJ family. (147 aa)
fliIATP synthase; Involved in type III protein export during flagellum assembly; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
fliHFlagellar assembly protein H; Binds to and inhibits the function of flagella specific ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
fliGFlagellar motor switch protein G; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. (331 aa)
fliFHypothetical protein; The M ring may be actively involved in energy transduction. Belongs to the FliF family. (560 aa)
fliEFlagellar hook-basal body protein FliE; Forms a junction between the M-ring and FlgB during flagella biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (104 aa)
fliTFlagellar biosynthesis protein FliT; Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus. (122 aa)
fliSFlagellar protein FliS; Flagellin specific chaperone; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
fliDFlagellar protein FliD; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (468 aa)
ANA30103.1Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (493 aa)
fliAFlagellar biosynthesis sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (239 aa)
flhDTranscriptional regulator; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (113 aa)
flhCTranscriptional regulator; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family. (192 aa)
motAFlagellar motor protein MotA; With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
motBFlagellar motor protein MotB; With MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
flhBFlagellar biosynthesis protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (383 aa)
flhAFlagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (692 aa)
osmBLipoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (72 aa)
ANA29661.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (564 aa)
ssaKSalmonella pathogenicity island 2 protein; member of a type III secretion system involved in the survival and replication of Salmonella in a host cell; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
flgLWith FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
flgKWith FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
flgIFlagellar basal body P-ring biosynthesis protein FlgA; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (365 aa)
flgHFlagellar basal body L-ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation. (232 aa)
flgGMakes up the distal portion of the flagellar basal body rod; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
flgFFlagellar basal body rod protein FlgF; FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
flgEThe hook connects flagellar basal body to the flagellar filament; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
flgDFlagellar basal body rod modification protein; Required for flagellar hook formation. May act as a scaffolding protein. (232 aa)
flgCWith FlgF and B makes up the proximal portion of the flagellar basal body rod; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)
flgBHypothetical protein; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (138 aa)
flgAFlagellar basal body P-ring biosynthesis protein FlgA; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (219 aa)
flgMNegative regulator of flagellin synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (97 aa)
flgNFlagellar biosynthesis protein FlgN; Export chaperone for FlgK and FlgL; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
ANA31670.1Membrane protein; OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (350 aa)
palPeptidoglycan-associated outer membrane lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (174 aa)
Your Current Organism:
Salmonella enterica diarizonae
NCBI taxonomy Id: 59204
Other names: ATCC 43973, CCUG 30040, CIP 82.31, DSM 14847, NCTC 10060, S. enterica subsp. diarizonae, Salmonella cholerae-suis subsp. diarizonae, Salmonella choleraesuis subsp. diarizonae, Salmonella enterica IIIb, Salmonella enterica serovar IIIb, Salmonella enterica subsp. IIIb, Salmonella enterica subsp. Subsp. IIIb, Salmonella enterica subsp. diarizonae
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