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gltD-1 gltD-1 TGAM_0168 TGAM_0168 pyrK pyrK pyrC pyrC glnA glnA gcvT gcvT pyrD pyrD pdha pdha pdhf pdhf pdhx pdhx pdhb pdhb pyrH pyrH glmS-1 glmS-1 nagA nagA gltA-1 gltA-1 TGAM_0402 TGAM_0402 nrdA nrdA dcd dcd tdk tdk hisC-1 hisC-1 purF purF purC-1 purC-1 purM purM purT purT purE purE purD purD purS purS purQ purQ purL purL guaB guaB guaA_C guaA_C guaA_N guaA_N gltD-2 gltD-2 TGAM_0895 TGAM_0895 gltA-2 gltA-2 gcvH gcvH glmS-2 glmS-2 purA purA soxB soxB soxA soxA gltD-3 gltD-3 TGAM_1074 TGAM_1074 tdh tdh thyX thyX purC-2 purC-2 TGAM_1304 TGAM_1304 lysA lysA glyA glyA racD-1 racD-1 racD-2 racD-2 surE surE upp upp asnA asnA gatD-2 gatD-2 maiA maiA ahcY ahcY purB purB TGAM_1604 TGAM_1604 TGAM_1605 TGAM_1605 hisZ hisZ hisG hisG hisD hisD hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI hisC-2 hisC-2 TGAM_1615 TGAM_1615 proC proC TGAM_1617 TGAM_1617 pyrG pyrG gcvP2 gcvP2 gcvP1 gcvP1 tmk tmk lysC lysC thrB thrB thrC-1 thrC-1 asd asd ghd-1 ghd-1 ghd-2 ghd-2 nuc nuc pyrF pyrF pyrE pyrE asnB asnB hom hom kbl kbl thrC-2 thrC-2 pyrB pyrB pyrI pyrI glmM glmM TGAM_2143 TGAM_2143
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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gltD-1Glutamate synthase [NADPH] small chain (gltD). (356 aa)
TGAM_0168Nucleoside triphosphate phosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (184 aa)
pyrKDihydroorotate dehydrogenase electron transfer subunit (pyrK); Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (230 aa)
pyrCDihydroorotase (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (407 aa)
glnAGlutamine synthetase (glnA). (446 aa)
gcvTGlycine cleavage system T protein (aminomethyltransferase) (gcvT); The glycine cleavage system catalyzes the degradation of glycine. (398 aa)
pyrDDihydroorotase dehydrogenase (pyrD); Catalyzes the conversion of dihydroorotate to orotate. (300 aa)
pdhaProline dehydrogenase, alpha subunit (pdha). (481 aa)
pdhfProline dehydrogenase, gamma subunit (pdhf). (169 aa)
pdhxProline dehydrogenase, delta subunit (pdhx). (90 aa)
pdhbProline dehydrogenase, beta subunit (pdhb). (362 aa)
pyrHUridylate kinase (pyrH); Catalyzes the reversible phosphorylation of UMP to UDP. (225 aa)
glmS-1Glucosamine--fructose-6-phosphate aminotransferase, sugar isomerase (SIS) domain (glmS); 1 probable transmembrane helix predicted by modhmm. (338 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase (nagA). (381 aa)
gltA-1Glutamate synthase (NADPH), homotetrameric (gltA). (471 aa)
TGAM_0402Cytochrome-c3 hydrogenase, gamma subunit. (283 aa)
nrdARibonucleoside-diphosphate reductase alpha subunit (nrdA); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (911 aa)
dcdDeoxycytidine triphosphate deaminase (dCTP deaminase) (dcd); Catalyzes the deamination of dCTP to dUTP. (157 aa)
tdkThymidine kinase (tdk). (194 aa)
hisC-1Histidinol-phosphate aminotransferase (hisC). (316 aa)
purFAmidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (452 aa)
purC-1Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC); Belongs to the SAICAR synthetase family. (235 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase (purM). (334 aa)
purTPhosphoribosylglycinamide formyltransferase 2 (purT); Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (430 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit (AIR carboxylase) (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (143 aa)
purDPhosphoribosylamine--glycine ligase (purD). (438 aa)
purSPhosphoribosylformylglycinamidine (FGAM) synthase, PurS component (purS); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and Pur [...] (80 aa)
purQPhosphoribosylformylglycinamidine synthase I, purQ component (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and [...] (223 aa)
purLPhosphoribosylformylglycinamidine synthase II, purL component (purL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL an [...] (712 aa)
guaBInosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD) (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa)
guaA_CGMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (C terminal domain) (guaA_C); Catalyzes the synthesis of GMP from XMP. (311 aa)
guaA_NGMP synthase - glutamine amidotransferase subunit (N terminal domain) (guaA_N); Catalyzes the synthesis of GMP from XMP. (188 aa)
gltD-2Glutamate synthase [NADPH] small chain (gltD). (350 aa)
TGAM_0895Cytochrome-c3 hydrogenase, gamma subunit. (295 aa)
gltA-2Glutamate synthase (NADPH), homotetrameric (gltA). (482 aa)
gcvHGlycine cleavage system protein H (gcvH); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (134 aa)
glmS-2Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) (glmS); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (602 aa)
purAAdenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (339 aa)
soxBSarcosine oxidase, subunit beta (SoxB). (386 aa)
soxASarcosine oxidase, subunit alpha (SoxA). (492 aa)
gltD-3Glutamate synthase [NADPH] small chain (gltD). (366 aa)
TGAM_1074Deoxycytidylate deaminase (dCMP deaminase). (177 aa)
tdhL-threonine 3-dehydrogenase (tdh). (349 aa)
thyXThymidylate synthase, flavin-dependent (thyX); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (251 aa)
purC-2Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase (purC); Belongs to the SAICAR synthetase family. (219 aa)
TGAM_1304Ferredoxin, putative. (67 aa)
lysADiaminopimelate decarboxylase (lysA). (411 aa)
glyASerine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
racD-1Aspartate racemase (racD). (234 aa)
racD-2Aspartate racemase (racD). (226 aa)
surEAcid phosphatase SurE (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (266 aa)
uppUracil phosphoribosyltransferase (upp); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (224 aa)
asnAL-asparaginase (asnA). (306 aa)
gatD-2Glutamyl-tRNA(Gln) amidotransferase subunit D (gatD). (328 aa)
maiAMaleate cis-trans isomerase (maiA). (237 aa)
ahcYAdenosylhomocysteinase (ahcY); May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (421 aa)
purBAdenylosuccinate lyase (purB); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (451 aa)
TGAM_1604Permease, major facilitator superfamily; 12 probable transmembrane helices predicted by modhmm. (399 aa)
TGAM_1605Carbon-nitrogen hydrolase. (223 aa)
hisZATP phosphoribosyltransferase regulatory subunit, putative (HisZ); Based on BLAST alignments, this is second copy of HisS, shorter at C-terminus. The tRNA synthetase class II motives are not detected in this copy. (296 aa)
hisGATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (205 aa)
hisDHistidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (375 aa)
hisBImidazoleglycerol-phosphate dehydratase (hisB). (178 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA). (226 aa)
hisFImidazole glycerol phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisIBifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (HisI); In the N-terminal section; belongs to the PRA-CH family. (209 aa)
hisC-2Histidinol-phosphate aminotransferase (hisC). (340 aa)
TGAM_1615HAD-superfamily hydrolase, putative; Belongs to subfamily IA, variant 1. (241 aa)
proCPyrroline-5-carboxylate reductase (proC); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (258 aa)
TGAM_1617SSV1 integrase fragment-like protein (orf D-335). (278 aa)
pyrGCTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (533 aa)
gcvP2Glycine dehydrogenase [decarboxylating] subunit 2 (glycine cleavage system P- protein) (gcvP2); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (502 aa)
gcvP1Glycine dehydrogenase [decarboxylating] subunit 1 (glycine cleavage system P- protein) (gcvP1); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (448 aa)
tmkThymidylate kinase (dTMP kinase) (tmk). (208 aa)
lysCAspartate kinase (lysC). (351 aa)
thrBHomoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (292 aa)
thrC-1Threonine synthase (thrC); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (390 aa)
asdAspartate-semialdehyde dehydrogenase (asd). (334 aa)
ghd-1Glutamate dehydrogenase N-terminal domain, containing dimerization domain (ghd). (236 aa)
ghd-2Glutamate dehydrogenase C-terminal domain (ghd). (183 aa)
nucThermonuclease (nuc); 1 probable transmembrane helix predicted by modhmm. (195 aa)
pyrFOrotidine 5'-phosphate decarboxylase (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (211 aa)
pyrEOrotate phosphoribosyltransferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (189 aa)
asnBAsparagine synthase (glutamine-hydrolyzing) (asnB). (479 aa)
homHomoserine dehydrogenase (hom). (333 aa)
kbl2-amino-3-oxobutanoate synthase (glycine C-acetyltransferase) (kbl). (395 aa)
thrC-2Threonine synthase (thrC). (379 aa)
pyrBAspartate carbamoyltransferase, catalytic subunit (pyrB). (308 aa)
pyrIAspartate carbamoyltransferase, regulatory subunit (pyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (151 aa)
glmMPhosphohexomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (449 aa)
TGAM_2143Asparagine synthetase related protein. (528 aa)
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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