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| | tmcA | Predicted P-loop ATPase fused to an acetyltransferase (GNAT) family; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (811 aa) |
| | asnS-2 | Asparaginyl-tRNA synthetase related protein (asnS). (300 aa) |
| | rpl10E-2 | LSU ribosomal protein L10 (rpl10E); Belongs to the universal ribosomal protein uL16 family. (182 aa) |
| | rpl3P | LSU ribosomal protein L3P (rpl3P); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (346 aa) |
| | rpl4P | LSU ribosomal protein L4P (rpl4P); One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (255 aa) |
| | rpl23P | LSU ribosomal protein L23P (rpl23P); Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (86 aa) |
| | rpl2P | LSU ribosomal protein L2P (rpl2P); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa) |
| | rps19P | SSU ribosomal protein S19P (rps19P); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (133 aa) |
| | rpl22P | LSU ribosomal protein L22P (rpl22P); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (156 aa) |
| | rps3P | SSU ribosomal protein S3P (rps3P); Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (209 aa) |
| | rpl29P | LSU ribosomal protein L29P (rpl29P); Belongs to the universal ribosomal protein uL29 family. (66 aa) |
| | suI1 | Protein translation factor SUI1-like protein (SUI1); Belongs to the SUI1 family. (98 aa) |
| | rnp1 | Ribonuclease P protein component 1 (rnp1); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (89 aa) |
| | rps17P | SSU ribosomal protein S17P (rps17P); One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa) |
| | rpl14P | LSU ribosomal protein L14P (rpl14P); Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa) |
| | rpl24P | LSU ribosomal protein L24P (rpl24P); Located at the polypeptide exit tunnel on the outside of the subunit. (121 aa) |
| | rps4E | SSU ribosomal protein S4E (rps4E); Belongs to the eukaryotic ribosomal protein eS4 family. (243 aa) |
| | rpl5P | LSU ribosomal protein L5P (rpl5P); This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (183 aa) |
| | rps14P | SSU ribosomal protein S14P (rps14P); Binds 16S rRNA, required for the assembly of 30S particles. (56 aa) |
| | rps8P | SSU ribosomal protein S8P (rps8P); One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rpl6P | LSU ribosomal protein L6P (rpl6P); This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa) |
| | rpl32E | LSU ribosomal protein L32E (rpl32E); Belongs to the eukaryotic ribosomal protein eL32 family. (127 aa) |
| | rpl19E | LSU ribosomal protein L19E (rpl19E); Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa) |
| | rpl18P | LSU ribosomal protein L18P (rpl18P); This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (201 aa) |
| | rps5P | SSU ribosomal protein S5P (rps5P); With S4 and S12 plays an important role in translational accuracy. (234 aa) |
| | rpl30P | LSU ribosomal protein L30P (rpl30P). (155 aa) |
| | rpl15P | LSU ribosomal protein L15P (rpl15P); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa) |
| | rpl34E | LSU ribosomal protein L34E (rpl34E); Belongs to the eukaryotic ribosomal protein eL34 family. (89 aa) |
| | rpl14E | LSU ribosomal protein L14E (rpl14E); Belongs to the eukaryotic ribosomal protein eL14 family. (83 aa) |
| | truB | Centromere binding protein CBF5/pseudouridine synthase truB-like protein (truB); Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (334 aa) |
| | rps13P | SSU ribosomal protein S13P (rps13P); Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa) |
| | rps4P | SSU ribosomal protein S4P (rps4P); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa) |
| | rps11P | SSU ribosomal protein S11P (rps11P); Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (138 aa) |
| | rpoD | DNA-directed RNA polymerase subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (260 aa) |
| | rpl18E | LSU ribosomal protein L18E (rpl18E); Belongs to the eukaryotic ribosomal protein eL18 family. (121 aa) |
| | rpl13P | LSU ribosomal protein L13P (rpl13P); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa) |
| | rps9P | SSU ribosomal protein S9P (rps9P); Belongs to the universal ribosomal protein uS9 family. (135 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N (rpoN); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (70 aa) |
| | rpoK | DNA-directed RNA polymerase subunit K (rpoK); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (57 aa) |
| | rps2P | SSU ribosomal protein S2P (rps2P); Belongs to the universal ribosomal protein uS2 family. (201 aa) |
| | rpl40E | LSU ribosomal protein L40E (rpl40E); Belongs to the eukaryotic ribosomal protein eL40 family. (51 aa) |
| | serS | Seryl-tRNA synthetase (serS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (455 aa) |
| | TGAM_1940 | Translation factor, putative, Sua5/YciO/YrdC/YwlC family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (343 aa) |
| | rpoH | DNA-directed RNA polymerase subunit H (rpoH); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (82 aa) |
| | rpoB | DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1122 aa) |
| | rpoA1 | DNA-directed RNA polymerase subunit A' (rpoA1); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (905 aa) |
| | rpoA2 | DNA-directed RNA polymerase subunit A' (rpoA2); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (391 aa) |
| | rpl30E | LSU ribosomal protein L30E (rpl30E); Belongs to the eukaryotic ribosomal protein eL30 family. (102 aa) |
| | nusA-2 | Transcription termination-antitermination factor, NusA-like protein (nusA); Participates in transcription termination. Belongs to the NusA family. (145 aa) |
| | rps12P | SSU ribosomal protein S12P (rps12P); With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa) |
| | rps7P | SSU ribosomal protein S7P (rps7P); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa) |
| | rumA-2 | 23S rRNA (uracil-5-)-methyltransferase (rumA); Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (421 aa) |
| | nusA-1 | Transcription elongation factor, putative NusA-like protein (nusA); Contains 1 KH domain. (170 aa) |
| | aspS | Aspartyl-tRNA synthetase (aspS); Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). (438 aa) |
| | pth | Peptidyl-tRNA hydrolase (pth); The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (122 aa) |
| | truD | tRNA pseudouridylate synthase D (TruD); Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (415 aa) |
| | rpl7AE | LSU ribosomal protein L7AE (rpl7AE); Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (123 aa) |
| | rps28E | SSU ribosomal protein S28E (rps28E); Belongs to the eukaryotic ribosomal protein eS28 family. (70 aa) |
| | rpl24E | LSU ribosomal protein L24E (rpl24E); Binds to the 23S rRNA. (68 aa) |
| | infB | Translation initiation factor IF-2 (infB); Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (600 aa) |
| | rumA-1 | 23S rRNA (uracil-5-)-methyltransferase (rumA); Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (421 aa) |
| | TGAM_1847 | Conserved hypothetical protein. (199 aa) |
| | TGAM_1845 | RNA binding protein, containing PUA domain. (172 aa) |
| | TGAM_1839 | Conserved hypothetical protein; Belongs to DUF509 family. (130 aa) |
| | leuS | Leucyl-tRNA synthetase (leuS); Belongs to the class-I aminoacyl-tRNA synthetase family. (968 aa) |
| | tfx | Archaeal regulatory protein tfx, LuxR family (tfx). (146 aa) |
| | rnp3 | Ribonuclease P protein component 3 (rnp3); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (214 aa) |
| | rpl15E | LSU ribosomal protein L15E (rpl15E); Belongs to the eukaryotic ribosomal protein eL15 family. (194 aa) |
| | gltX | Glutamyl-tRNA synthetase (gltX); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (571 aa) |
| | TGAM_1765 | GTP hydrolase, putative; Contains P-loop containing nucleoside triphosphate hydrolase, molybdopterin guanine dinucleotide synthesis protein B and cleavage/polyadenylation factor IA subunit clp1p motives. (362 aa) |
| | rpl37E | LSU ribosomal protein L37E (rpl37E); Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (63 aa) |
| | TGAM_1738 | Small nuclear ribonucleoprotein (snRNP)-like protein, Sm-like protein; Belongs to the snRNP Sm proteins family. (76 aa) |
| | glyS | Glycyl-tRNA synthetase (glyS); Catalyzes the attachment of glycine to tRNA(Gly). (570 aa) |
| | fbpA | Fibronectin-binding protein A (FbpA). (650 aa) |
| | rpl39E | LSU ribosomal protein L39E (rpl39E); Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa) |
| | rpl31E | LSU ribosomal protein L31E (rpl31E); Belongs to the eukaryotic ribosomal protein eL31 family. (90 aa) |
| | eif6 | Translation initiation factor 6 (eif6); Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (228 aa) |
| | rplXA | LSU ribosomal protein LXA (rplXA). (77 aa) |
| | rgy | Reverse gyrase (rgy); Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. (1226 aa) |
| | TGAM_1676 | Conserved hypothetical protein; Belongs to Auto_anti-p27 family (PF06677). (107 aa) |
| | eIF-2BII | Translation initiation factor eIF-2B subunit 2-like (eIF-2BII); Belongs to the eIF-2B alpha/beta/delta subunits family. (275 aa) |
| | trmY | Conserved hypothetical protein; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family. (202 aa) |
| | truA | tRNA-pseudouridine synthase A (truA); Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (267 aa) |
| | TGAM_1635 | Alanyl-tRNA synthetase related protein. (213 aa) |
| | rps6E | SSU ribosomal protein S6E (rps6E); Belongs to the eukaryotic ribosomal protein eS6 family. (125 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit, putative (HisZ); Based on BLAST alignments, this is second copy of HisS, shorter at C-terminus. The tRNA synthetase class II motives are not detected in this copy. (296 aa) |
| | eIF-2BI | Translation initiation factor eIF-2B subunit 1 (eIF-2BI); Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (357 aa) |
| | cysS | Cysteinyl-tRNA synthetase (cysS). (476 aa) |
| | TGAM_1546 | CAAX amino terminal family protease; 4 probable transmembrane helices predicted by modhmm. (202 aa) |
| | rnp4 | Ribonuclease P protein component 4 (rnp4); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (123 aa) |
| | TGAM_1514 | Conserved hypothetical protein; virR related protein, belongs to UPF0066 family. (218 aa) |
| | metG | Methionyl-tRNA synthetase (metG); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (739 aa) |
| | rtcB | Conserved hypothetical protein; Belongs to UPF0027 family; Belongs to the RtcB family. (479 aa) |
| | TGAM_1502 | SAM-dependent tRNA/rRNA cytosine-C5 methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (312 aa) |
| | TGAM_1501 | Conserved hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). (142 aa) |
| | TGAM_1498 | Brix-domain ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome. (211 aa) |
| | TGAM_1497 | Conserved hypothetical protein. (90 aa) |
| | rpl44E | LSU ribosomal protein L44E (rpl44E); Binds to the 23S rRNA. (94 aa) |
| | rps27E | SSU ribosomal protein S27E (rps27E). (65 aa) |
| | thiI-2 | Thiamin biosynthesis protein (thiI); Does not contain THUMP domain in N-terminus as tg1481. (197 aa) |
| | thiI-1 | Thiamine biosynthesis protein (ThiI); Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (380 aa) |
| | pol | DNA-directed DNA polymerase, B family (pol). (775 aa) |
| | TGAM_1424 | RNA-binding protein, containing KH domain. (234 aa) |
| | eIF1A | eIF1A translation initiation factor eIF-1A (eIF1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (172 aa) |
| | nep1 | Ribosome biogenesis protein NEP1-like protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (216 aa) |
| | TGAM_1416 | tRNA-binding protein, putative. (246 aa) |
| | TGAM_1410 | Serine/threonine protein kinase, RIO-like protein. (310 aa) |
| | fusA | Translation elongation factor EF-2 (fusA); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. E [...] (732 aa) |
| | TGAM_1396 | SAM-dependent tRNA/rRNA cytosine-C5 methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (309 aa) |
| | rpl35AE | LSU ribosomal protein L35AE (rpl35AE); Belongs to the eukaryotic ribosomal protein eL33 family. (87 aa) |
| | trm1 | N2,N2-dimethylguanosine tRNA methyltransferase (trm1); Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (378 aa) |
| | TGAM_1383 | Radical SAM protein, predicted Fe-S oxidoreductase. (324 aa) |
| | rtcA | RNA 3'-terminal phosphate cyclase (rtcA); Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (344 aa) |
| | TGAM_1332 | Thioesterase, putative. (131 aa) |
| | TGAM_1324 | Methylase, RNA modification protein, putative. (335 aa) |
| | topA | DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] (712 aa) |
| | eIF2G | Translation initiation factor eIF-2, subunit gamma (eIF2G) (eIF2G); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (411 aa) |
| | tfb-2 | Transcription initiation factor TFIIB (tfb); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (300 aa) |
| | rps19E | SSU ribosomal protein S19E (rps19E); May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa) |
| | TGAM_1194 | RNA-binding protein, putative; Contains CRS1 / YhbY domain. (139 aa) |
| | TGAM_1186 | Nucleotide binding protein, putative, containing PIN domain. (167 aa) |
| | TGAM_1164 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (178 aa) |
| | pheT | Phenylalanyl-tRNA synthetase, beta subunit (pheT_arch). (568 aa) |
| | pheS | Phenylalanyl-tRNA synthetase, alpha subunit (pheS); Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (499 aa) |
| | arcTGT | Archaeosine tRNA-guanine transglycosylase (ArcTGT); Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (585 aa) |
| | hypE-2 | Hydrogenase expression/formation related protein (hypE). (328 aa) |
| | TGAM_1139 | Predicted ATPase, RNase L inhibitor-like protein. (590 aa) |
| | TGAM_1102 | Predicted ATPase of the PP-loop superfamily. (262 aa) |
| | hypE-1 | Hydrogenase expression/formation related protein (hypE). (332 aa) |
| | TGAM_1093 | S-adenosyl-L-methionine-dependent methyltransferase. (385 aa) |
| | rnz | Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (314 aa) |
| | TGAM_1080 | RNA-binding protein, containing KH type 1 domain; Possibly a nusA transcription factor homolog. (62 aa) |
| | tyrS | Tyrosyl-tRNA synthetase (tyrS); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (375 aa) |
| | rps10P | SSU ribosomal protein S10P (rps10P); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | tuf | Elongation factor 1-alpha (EF-1-alpha) (Elongation factor Tu) (EF-Tu) (tuf); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (428 aa) |
| | proS | Prolyl-tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (483 aa) |
| | tfs | Transcription elongation factor S (TFS_arch); Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (110 aa) |
| | eIF-5A | Translation initiation factor eIF-5A (hypusine containing) (eIF-5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (136 aa) |
| | tiaS | Predicted DNA-binding protein containing OB-fold nucleic acid binding domain; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. (475 aa) |
| | TGAM_0102 | lplA-like lipoate-protein ligase A related. (287 aa) |
| | TGAM_0103 | Signal peptidase, peptidase S26B; 1 probable transmembrane helix predicted by modhmm. (138 aa) |
| | dp2 | DNA polymerase II large subunit DP2, intein containing (dp2/polC); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1459 aa) |
| | radA | DNA repair and recombination protein RadA (radA); Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (355 aa) |
| | TGAM_0149 | Alanyl-tRNA synthetase-related protein (C-terminus). (405 aa) |
| | TGAM_0150 | P-loop ATPase, MJ1599 type. (276 aa) |
| | taw3-2 | Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (199 aa) |
| | aeF1-B | Translation elongation factor aEF-1, subunit beta (aeF1-B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (91 aa) |
| | TGAM_0183 | RNA-binding protein, putative; Contains 1 THUMP domain. (161 aa) |
| | TGAM_0197 | AAA family ATPase, type II secretion system protein, containing DOD-type homing endonuclease; Intein span: 515 - 1037. (1200 aa) |
| | TGAM_0202 | SAM-dependent RNA methylase, putative; Belongs to UPF0020 family, contains 1 THUMP domain. (365 aa) |
| | trpS | Tryptophanyl-tRNA synthetase (trpS); Catalyzes the attachment of tryptophan to tRNA(Trp). (384 aa) |
| | tfe | Transcription factor TFIIE subunit alpha-like protein (tfe); Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and desta [...] (221 aa) |
| | hypA | [NiFe] hydrogenase maturation protein (hypA); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (139 aa) |
| | hybD | [NiFe]-hydrogenase maturation protease (HybD/HycI/HoxM). (157 aa) |
| | hypC-1 | [NiFe] hydrogenase maturation protein (hypC). (84 aa) |
| | hypC-2 | [NiFe] hydrogenase maturation protein (hypC). (86 aa) |
| | hypD | [NiFe] hydrogenase maturation protein (hypD). (374 aa) |
| | hypF | [NiFe] hydrogenase maturation protein (hypF). (772 aa) |
| | hypE | [NiFe] hydrogenase maturation protein (hypE). (338 aa) |
| | kaeI | Class I apurinic AP-endonuclease (AP-lyase) (KaeI); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (325 aa) |
| | TGAM_0276 | Histone acetyltransferase-like protein; Contains Elp3 (Elongator protein 3), belongs to GNAT methyltransferases family. (589 aa) |
| | TGAM_0290 | tRNA/rRNA cytosine-C5-methylase, putative; Belongs to Sun/NOL1/NOP family. Contains 1 PUA domain and 1 SAM binding domain; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (389 aa) |
| | hisS | Histidyl-tRNA synthetase (hisS); Belongs to the class-II aminoacyl-tRNA synthetase family. (435 aa) |
| | alaS | Alanyl-tRNA synthetase (alaS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (913 aa) |
| | spoU | RNA methyltransferase (spoU/TrmH); Belongs to trmH/spoU family of rRNA methylases. (243 aa) |
| | kptA | RNA 2'-phosphotransferase (kptA); Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. (179 aa) |
| | cca | tRNA nucleotidyltransferase (CCA adding enzyme) (cca); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (454 aa) |
| | nrdA | Ribonucleoside-diphosphate reductase alpha subunit (nrdA); Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (911 aa) |
| | TGAM_0434 | Phosphoesterase, putative; Contains PHP domain. (421 aa) |
| | tbp-1 | TATA box-binding protein, transcription initiation factor TFIID (tbp); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (192 aa) |
| | flpA | Fibrillarin pre-rRNA splicing protein (flpA); Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (226 aa) |
| | TGAM_0465 | RNA-binding protein, putative; Contains THUMP domain. (355 aa) |
| | tfb-1 | Transcription initiation factor TFIIB (tfb); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (303 aa) |
| | TGAM_0477 | Archaeal histone B (Archaeal histone A2). (67 aa) |
| | TGAM_0479 | Nucleotide-binding protein, putative; RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. Belongs to the HARP family. (207 aa) |
| | rpl26E | Ribosomal protein L26E (rpl26E); Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (152 aa) |
| | rpl11P | LSU ribosomal protein L11P (rpl11P); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (165 aa) |
| | rpl1P | LSU ribosomal protein L1P (rpl1P); Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa) |
| | rpl10E-1 | LSU ribosomal protein L10E (rpl10E); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (340 aa) |
| | rpl12A | LSU ribosomal protein L12A (rpl12A); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (106 aa) |
| | TGAM_0495 | Signal peptidase I, S26B/S24 family; Serine protease; 4 probable transmembrane helices predicted by modhmm. (352 aa) |
| | rpoE1 | DNA-directed RNA polymerase subunit E' (rpoE1). (186 aa) |
| | rps24E | SSU ribosomal protein S24E (rps24E); Belongs to the eukaryotic ribosomal protein eS24 family. (98 aa) |
| | rps27AE | SSU ribosomal protein S27AE (rps27AE); Belongs to the eukaryotic ribosomal protein eS31 family. (56 aa) |
| | TGAM_0514 | Zinc-finger protein, translation initiation factor 2 beta related protein; UCP015877 member. (207 aa) |
| | TGAM_0532 | SAM-dependent tRNA/rRNA cytosine-C5 methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (443 aa) |
| | TGAM_0568 | Radical SAM protein, putative Fe-S oxidoreductase. (317 aa) |
| | ileS | Isoleucyl-tRNA synthetase (ileS); Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1066 aa) |
| | rnp2 | Ribonuclease P protein component 2 (rnp2); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (120 aa) |
| | TGAM_0610 | SAM-dependent methyltransferase, putative; Belongs to DUF890 family. (247 aa) |
| | rps8E | SSU ribosomal protein S8E (rps8E). (130 aa) |
| | taw2 | Met-10 like-protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (368 aa) |
| | TGAM_0680 | tRNA (guanine-N(1)-)-methyltransferase. (369 aa) |
| | valS | Valyl-tRNA synthetase (valS); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (888 aa) |
| | eRF1 | Peptide chain release factor eRF/aRF, subunit 1 (eRF1/prf1); Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (418 aa) |
| | TGAM_0697 | Lipoate-protein ligase A. (323 aa) |
| | argS | Arginyl-tRNA synthetase (argS); Belongs to the class-I aminoacyl-tRNA synthetase family. (640 aa) |
| | asnS-1 | Asparaginyl-tRNA synthetase (asnS); Belongs to the class-II aminoacyl-tRNA synthetase family. (430 aa) |
| | taw1 | Radical SAM protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (336 aa) |
| | TGAM_0787 | RNA methylase, putative; Belongs to UPF0020 family. (366 aa) |
| | rpoP | DNA-directed RNA polymerase subunit P (rpoP); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (91 aa) |
| | rpl37AE | LSU ribosomal protein L37AE (rpl37AE). (86 aa) |
| | eIF2A | Translation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (273 aa) |
| | nop10 | Nucleolar RNA-binding protein, Nop10p family; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (59 aa) |
| | tbp-2 | TATA box-binding protein, transcription initiation factor TFIID (tbp); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (182 aa) |
| | rps17E | SSU ribosomal protein S17E (rps17E); Belongs to the eukaryotic ribosomal protein eS17 family. (67 aa) |
| | dhys | Deoxyhypusine synthase (dhys); Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (336 aa) |
| | rps3AE | SSU ribosomal protein S3AE (rps3AE); Belongs to the eukaryotic ribosomal protein eS1 family. (200 aa) |
| | rps15P | SSU ribosomal protein S15P (rps15P). (151 aa) |
| | hel308 | Ski2-type helicase, putative; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (720 aa) |
| | TGAM_0880 | Ribosomal RNA adenine dimethylase, putative. (254 aa) |
| | ksgA | Ribosomal RNA adenine methylase transferase (Dimethyladenosine transferase) (ksgA); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (278 aa) |
| | rpoF | DNA-directed RNA polymerase subunit F (rpoF). (122 aa) |
| | rpl21E | LSU ribosomal protein L21E (rpl21E); Belongs to the eukaryotic ribosomal protein eL21 family. (98 aa) |
| | pus10 | RNA-binding protein, pseudouridine synthase family; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (386 aa) |
| | gatD-1 | L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D (gatD); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (439 aa) |
| | gatE | Archaeal Glu-tRNAGln amidotransferase subunit E (gatE); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (628 aa) |
| | TGAM_0925 | Met-10 like-protein, putative SAM-dependent methyltransferase. (331 aa) |
| | TGAM_0991 | GTP-binding protein; Contains 1 GTP1/OBG domain and 1 TGS domain. (388 aa) |
| | TGAM_1001 | Conserved hypothetical protein. (222 aa) |
| | rpoL | DNA-directed RNA polymerase subunit L (rpoL); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (95 aa) |
| | csl4 | RNA-binding protein, containing S1 RNA binding domain; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (195 aa) |
| | thrS | Threonyl-tRNA synthetase (thrS); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family. (626 aa) |
| | TGAM_1011 | Serine/threonine protein kinase, RIO1 family. (221 aa) |
| | TGAM_0020 | PP-loop ATPase, YdaO-type. (325 aa) |
| | TGAM_0024 | Zinc-dependant protease, putative; 6 probable transmembrane helices predicted by modhmm. (207 aa) |
| | TGAM_0074 | Putative nucleotide binding protein, containing TRAM domain. (75 aa) |
| | taw3 | Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (209 aa) |
| | TGAM_2130 | PP-loop ATPase, YdaO-type. (304 aa) |
| | miaB | RNA modification enzyme, MiaB family (MiaB). (424 aa) |
| | TGAM_2126 | Signal peptidase, peptidase S26B; 2 probable transmembrane helices predicted by modhmm. (191 aa) |
| | TGAM_2122 | RNA-binding protein, containing PUA domain. (568 aa) |
| | fau | RNA-binding protein FAU-1, ribonuclease E-like protein (FAU); Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. (471 aa) |
| | TGAM_2067 | Met-10 like-protein, putative SAM-dependent methyltransferase. (336 aa) |
| | rfcS | Replication factor C, small subunit (rfcS); Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (333 aa) |
| | endA | tRNA-splicing endonuclease (endA); Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (168 aa) |
| | rimI | Ribosomal-protein-alanine acetyltransferase (rimI). (166 aa) |
| | lysS | Lysyl-tRNA synthetase (lysS); Belongs to the class-I aminoacyl-tRNA synthetase family. (525 aa) |
| | rrp4p | Exosome complex RNA-binding protein 1, Rrp4p-like protein (Rrp4p); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. (254 aa) |
| | eif2b | Translation initiation factor 2 beta subunit (eif2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (142 aa) |
