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rps5P rps5P rpl19E rpl19E rps14P rps14P rpl5P rpl5P rps4E rps4E rpl24P rpl24P rpl14P rpl14P rps17P rps17P rnp1 rnp1 rps3P rps3P rps19P rps19P rpl22P rpl22P TGAM_0279 TGAM_0279 flpA flpA TGAM_0464 TGAM_0464 gar1 gar1 rpl1P rpl1P rnp2 rnp2 eIF2A eIF2A nop10 nop10 rps15P rps15P srp19 srp19 rps10P rps10P TGAM_1186 TGAM_1186 TGAM_1285 TGAM_1285 TGAM_1410 TGAM_1410 nep1 nep1 TGAM_1424 TGAM_1424 top6B top6B TGAM_1498 TGAM_1498 rnp4 rnp4 eif6 eif6 TGAM_1738 TGAM_1738 rnp3 rnp3 rps28E rps28E rpl7AE rpl7AE rps7P rps7P rps12P rps12P rpl30E rpl30E srp54 srp54 rps2P rps2P rpl13P rpl13P rps4P rps4P rps13P rps13P rpl2P rpl2P rpl15P rpl15P rpl30P rpl30P
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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rps5PSSU ribosomal protein S5P (rps5P); With S4 and S12 plays an important role in translational accuracy. (234 aa)
rpl19ELSU ribosomal protein L19E (rpl19E); Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa)
rps14PSSU ribosomal protein S14P (rps14P); Binds 16S rRNA, required for the assembly of 30S particles. (56 aa)
rpl5PLSU ribosomal protein L5P (rpl5P); This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (183 aa)
rps4ESSU ribosomal protein S4E (rps4E); Belongs to the eukaryotic ribosomal protein eS4 family. (243 aa)
rpl24PLSU ribosomal protein L24P (rpl24P); Located at the polypeptide exit tunnel on the outside of the subunit. (121 aa)
rpl14PLSU ribosomal protein L14P (rpl14P); Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa)
rps17PSSU ribosomal protein S17P (rps17P); One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa)
rnp1Ribonuclease P protein component 1 (rnp1); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family. (89 aa)
rps3PSSU ribosomal protein S3P (rps3P); Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (209 aa)
rps19PSSU ribosomal protein S19P (rps19P); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (133 aa)
rpl22PLSU ribosomal protein L22P (rpl22P); The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (156 aa)
TGAM_0279Ribosome subunit biogenesis protein, putative; Belongs to UPF0113 family. (167 aa)
flpAFibrillarin pre-rRNA splicing protein (flpA); Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (226 aa)
TGAM_0464pre-mRNA splicing, snoRNA binding protein, NOP5/NOP56 related. (422 aa)
gar1Gar1-like small nucleolar rnp, putative (gar1). (99 aa)
rpl1PLSU ribosomal protein L1P (rpl1P); Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa)
rnp2Ribonuclease P protein component 2 (rnp2); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (120 aa)
eIF2ATranslation initiation factor 2 alpha subunit (eIF2A); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (273 aa)
nop10Nucleolar RNA-binding protein, Nop10p family; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (59 aa)
rps15PSSU ribosomal protein S15P (rps15P). (151 aa)
srp19Signal recognition particle, subunit SRP19 (srp19); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (109 aa)
rps10PSSU ribosomal protein S10P (rps10P); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
TGAM_1186Nucleotide binding protein, putative, containing PIN domain. (167 aa)
TGAM_1285Nucleotide binding protein, putative, containing PIN domain. (141 aa)
TGAM_1410Serine/threonine protein kinase, RIO-like protein. (310 aa)
nep1Ribosome biogenesis protein NEP1-like protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (216 aa)
TGAM_1424RNA-binding protein, containing KH domain. (234 aa)
top6BType II DNA topoisomerase VI, subunit B (Top6B); Relaxes both positive and negative superturns and exhibits a strong decatenase activity. (561 aa)
TGAM_1498Brix-domain ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome. (211 aa)
rnp4Ribonuclease P protein component 4 (rnp4); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (123 aa)
eif6Translation initiation factor 6 (eif6); Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (228 aa)
TGAM_1738Small nuclear ribonucleoprotein (snRNP)-like protein, Sm-like protein; Belongs to the snRNP Sm proteins family. (76 aa)
rnp3Ribonuclease P protein component 3 (rnp3); Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family. (214 aa)
rps28ESSU ribosomal protein S28E (rps28E); Belongs to the eukaryotic ribosomal protein eS28 family. (70 aa)
rpl7AELSU ribosomal protein L7AE (rpl7AE); Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (123 aa)
rps7PSSU ribosomal protein S7P (rps7P); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa)
rps12PSSU ribosomal protein S12P (rps12P); With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa)
rpl30ELSU ribosomal protein L30E (rpl30E); Belongs to the eukaryotic ribosomal protein eL30 family. (102 aa)
srp54Signal recognition particle, subunit SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (448 aa)
rps2PSSU ribosomal protein S2P (rps2P); Belongs to the universal ribosomal protein uS2 family. (201 aa)
rpl13PLSU ribosomal protein L13P (rpl13P); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rps4PSSU ribosomal protein S4P (rps4P); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa)
rps13PSSU ribosomal protein S13P (rps13P); Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (149 aa)
rpl2PLSU ribosomal protein L2P (rpl2P); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa)
rpl15PLSU ribosomal protein L15P (rpl15P); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (148 aa)
rpl30PLSU ribosomal protein L30P (rpl30P). (155 aa)
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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