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mtaP-1 mtaP-1 mtaD mtaD speH speH serA serA TGAM_0565 TGAM_0565 mat mat speE speE TGAM_0729 TGAM_0729 TGAM_1304 TGAM_1304 ahcY ahcY eIF-2BI eIF-2BI aspC-2 aspC-2 lysC lysC asd asd aspC-3 aspC-3 TGAM_1907 TGAM_1907 mtaP-2 mtaP-2 hom hom
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene co-occurrence
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co-expression
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mtaP-1Methylthioadenosine phosphorylase (mtaP); Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (257 aa)
mtaDMetal-dependent chlorohydrolase family protein; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family. (448 aa)
speHS-adenosylmethionine decarboxylase proenzyme (speH); Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (143 aa)
serAD-3-phosphoglycerate dehydrogenase, putative (serA); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (304 aa)
TGAM_0565D-isomer specific 2-hydroxyacid dehydrogenase. (333 aa)
matS-adenosylmethionine synthetase (mat); Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (405 aa)
speESpermidine synthase (speE); Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. (293 aa)
TGAM_0729Metal-dependent chlorohydrolase family protein. (399 aa)
TGAM_1304Ferredoxin, putative. (67 aa)
ahcYAdenosylhomocysteinase (ahcY); May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (421 aa)
eIF-2BITranslation initiation factor eIF-2B subunit 1 (eIF-2BI); Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (357 aa)
aspC-2Aspartate aminotransferase (aspC). (359 aa)
lysCAspartate kinase (lysC). (351 aa)
asdAspartate-semialdehyde dehydrogenase (asd). (334 aa)
aspC-3Aspartate aminotransferase (aspC). (392 aa)
TGAM_1907parB-like nuclease, putative. (242 aa)
mtaP-2Methylthioadenosine phosphorylase (mtaP); Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. (267 aa)
homHomoserine dehydrogenase (hom). (333 aa)
Your Current Organism:
Thermococcus gammatolerans
NCBI taxonomy Id: 593117
Other names: T. gammatolerans EJ3, Thermococcus gammatolerans EJ3, Thermococcus gammatolerans str. EJ3, Thermococcus gammatolerans strain EJ3
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