STRINGSTRING
AGB01289.1 AGB01289.1 AGB01290.1 AGB01290.1 AGB01291.1 AGB01291.1 AGB01292.1 AGB01292.1 AGB01293.1 AGB01293.1 AGB01294.1 AGB01294.1 AGB01295.1 AGB01295.1 AGB01296.1 AGB01296.1 AGB01297.1 AGB01297.1 AGB01445.1 AGB01445.1 AGB01693.1 AGB01693.1 AGB01694.1 AGB01694.1 AGB01695.1 AGB01695.1 AGB01696.1 AGB01696.1 AGB01697.1 AGB01697.1 AGB01705.1 AGB01705.1 AGB01707.1 AGB01707.1 AGB01708.1 AGB01708.1 AGB01710.1 AGB01710.1 AGB01711.1 AGB01711.1 AGB01715.1 AGB01715.1 AGB01716.1 AGB01716.1 AGB01717.1 AGB01717.1 AGB01718.1 AGB01718.1 AGB01719.1 AGB01719.1 AGB01737.1 AGB01737.1 AGB01738.1 AGB01738.1 AGB01742.1 AGB01742.1 AGB01743.1 AGB01743.1 AGB01744.1 AGB01744.1 AGB01745.1 AGB01745.1 AGB01746.1 AGB01746.1 AGB01767.1 AGB01767.1 AGB01768.1 AGB01768.1 AGB01769.1 AGB01769.1 AGB01912.1 AGB01912.1 AGB01927.1 AGB01927.1 AGB01928.1 AGB01928.1 AGB01929.1 AGB01929.1 AGB01930.1 AGB01930.1 AGB02011.1 AGB02011.1 AGB02183.1 AGB02183.1 AGB02264.1 AGB02264.1 mfnB mfnB AGB02315.1 AGB02315.1 AGB02356.1 AGB02356.1 AGB02364.1 AGB02364.1 AGB02380.1 AGB02380.1 AGB02431.1 AGB02431.1 AGB02737.1 AGB02737.1 cbiA-3 cbiA-3 AGB02772.1 AGB02772.1 AGB02773.1 AGB02773.1 AGB02774.1 AGB02774.1 AGB02775.1 AGB02775.1 AGB02776.1 AGB02776.1 AGB02777.1 AGB02777.1 AGB02778.1 AGB02778.1 AGB02900.1 AGB02900.1 AGB02901.1 AGB02901.1 AGB02987.1 AGB02987.1 AGB03312.1 AGB03312.1 AGB03313.1 AGB03313.1 AGB03314.1 AGB03314.1 AGB03409.1 AGB03409.1 AGB03467.1 AGB03467.1 mch mch AGB03531.1 AGB03531.1 ftr ftr AGB03591.1 AGB03591.1 AGB03592.1 AGB03592.1 AGB03593.1 AGB03593.1 AGB03594.1 AGB03594.1 AGB03595.1 AGB03595.1 AGB03596.1 AGB03596.1 AGB03597.1 AGB03597.1 AGB03598.1 AGB03598.1 AGB03599.1 AGB03599.1 AGB03600.1 AGB03600.1 AGB03601.1 AGB03601.1 mtrE mtrE mtrD mtrD mtrC mtrC mtrB mtrB mtrA mtrA AGB03611.1 AGB03611.1 mtrA-2 mtrA-2 AGB03613.1 AGB03613.1 mtd mtd mer mer AGB03682.1 AGB03682.1 AGB03698.1 AGB03698.1 AGB03699.1 AGB03699.1 AGB03700.1 AGB03700.1 AGB03701.1 AGB03701.1 AGB03879.1 AGB03879.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGB01289.1PFAM: Carboxymuconolactone decarboxylase family; TIGRFAM: alkylhydroperoxidase AhpD family core domain. (165 aa)
AGB01290.1Putative methanogenesis marker protein 7; PFAM: Methyl-coenzyme M reductase operon protein C; TIGRFAM: putative methanogenesis marker protein 7. (312 aa)
AGB01291.1Putative methanogenesis marker protein 17; PFAM: Uncharacterized protein conserved in archaea (DUF2113); TIGRFAM: putative methanogenesis marker protein 17. (194 aa)
AGB01292.1Putative methanogenesis marker protein 15; PFAM: BadF/BadG/BcrA/BcrD ATPase family; TIGRFAM: CoA-substrate-specific enzyme activase, putative; putative methanogenesis marker protein 15. (412 aa)
AGB01293.1Putative methanogenesis marker protein 5; PFAM: Uncharacterized protein conserved in archaea (DUF2112); TIGRFAM: putative methanogenesis marker protein 5. (148 aa)
AGB01294.1Putative methanogenesis marker protein 6; PFAM: Uncharacterized protein conserved in archaea (DUF2102); TIGRFAM: putative methanogenesis marker protein 6. (152 aa)
AGB01295.1TIGRFAM: putative methanogenesis marker protein 3; Belongs to the UPF0288 family. (509 aa)
AGB01296.1PFAM: ABC transporter; TIGRFAM: methyl coenzyme M reductase system, component A2. (537 aa)
AGB01297.1Soluble P-type ATPase; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC. (285 aa)
AGB01445.1beta-RFAP synthase; PFAM: GHMP kinases C terminal; GHMP kinases N terminal domain; Protein of unknown function (DUF98); TIGRFAM: beta-RFAP synthase. (510 aa)
AGB01693.1NADH:ubiquinone oxidoreductase chain I-like protein; PFAM: 4Fe-4S binding domain. (87 aa)
AGB01694.1Formylmethanofuran dehydrogenase subunit D; PFAM: Molydopterin dinucleotide binding domain. (136 aa)
AGB01695.1PFAM: Molybdopterin oxidoreductase; TIGRFAM: formylmethanofuran dehydrogenase subunit B. (441 aa)
AGB01696.1PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A. (569 aa)
AGB01697.1PFAM: GXGXG motif; TIGRFAM: formylmethanofuran dehydrogenase subunit C. (266 aa)
AGB01705.1PFAM: FmdE, Molybdenum formylmethanofuran dehydrogenase operon. (211 aa)
AGB01707.1Formate dehydrogenase, alpha subunit, archaeal-type; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: formate dehydrogenase, alpha subunit, archaeal-type. (689 aa)
AGB01708.1PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus. (383 aa)
AGB01710.1Formate dehydrogenase, alpha subunit, archaeal-type; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: formate dehydrogenase, alpha subunit, archaeal-type. (688 aa)
AGB01711.1PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus. (418 aa)
AGB01715.1PFAM: GXGXG motif; TIGRFAM: formylmethanofuran dehydrogenase subunit C. (268 aa)
AGB01716.1PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A. (576 aa)
AGB01717.1PFAM: Molybdopterin oxidoreductase; TIGRFAM: formylmethanofuran dehydrogenase subunit B. (458 aa)
AGB01718.1Formylmethanofuran dehydrogenase subunit D; PFAM: Molydopterin dinucleotide binding domain. (136 aa)
AGB01719.1NADH:ubiquinone oxidoreductase chain I-like protein; PFAM: 4Fe-4S binding domain. (87 aa)
AGB01737.1Formate dehydrogenase, alpha subunit, archaeal-type; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: formate dehydrogenase, alpha subunit, archaeal-type. (686 aa)
AGB01738.1PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus. (417 aa)
AGB01742.1Dissimilatory sulfite reductase (desulfoviridin), alpha/beta subunit; PFAM: 4Fe-4S binding domain. (86 aa)
AGB01743.1Formylmethanofuran dehydrogenase subunit D; PFAM: Molydopterin dinucleotide binding domain. (135 aa)
AGB01744.1PFAM: Molybdopterin oxidoreductase; TIGRFAM: formylmethanofuran dehydrogenase subunit B. (438 aa)
AGB01745.1PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A. (570 aa)
AGB01746.1PFAM: GXGXG motif; TIGRFAM: formylmethanofuran dehydrogenase subunit C. (266 aa)
AGB01767.1PFAM: TfuA-like protein. (217 aa)
AGB01768.1Putative methanogenesis marker protein 1; PFAM: YcaO-like family; TIGRFAM: uncharacterized domain; putative methanogenesis marker protein 1; bacteriocin biosynthesis docking scaffold, SagD family. (403 aa)
AGB01769.1Hypothetical protein. (130 aa)
AGB01912.1PFAM: Hydrogenase maturation protease; TIGRFAM: coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); hydrogenase maturation protease. (183 aa)
AGB01927.1PFAM: Methyl-coenzyme M reductase beta subunit, C-terminal domain; Methyl-coenzyme M reductase beta subunit, N-terminal domain; TIGRFAM: methyl-coenzyme M reductase, beta subunit. (434 aa)
AGB01928.1PFAM: Methyl-coenzyme M reductase operon protein D; TIGRFAM: methyl-coenzyme M reductase operon protein D. (167 aa)
AGB01929.1PFAM: Methyl-coenzyme M reductase gamma subunit; TIGRFAM: methyl-coenzyme M reductase, gamma subunit. (255 aa)
AGB01930.1Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (570 aa)
AGB02011.1Pyridoxamine 5'-phosphate oxidase-related, FMN binding protein; PFAM: Pyridoxamine 5'-phosphate oxidase. (134 aa)
AGB02183.1Pyridine nucleotide-disulfide oxidoreductase; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (427 aa)
AGB02264.1PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus. (340 aa)
mfnBHypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (228 aa)
AGB02315.1hisA/hisF family protein; PFAM: Histidine biosynthesis protein; TIGRFAM: hisA/hisF family protein; Belongs to the HisA/HisF family. (223 aa)
AGB02356.1Putative methanogenesis marker protein 10; PFAM: Radical SAM superfamily; Protein of unknown function (DUF512); TIGRFAM: putative methanogenesis marker protein 10. (408 aa)
AGB02364.1PFAM: Uncharacterized protein conserved in archaea (DUF2111). (140 aa)
AGB02380.1Hydrogenase maturation factor; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain. (442 aa)
AGB02431.1Putative methanogenesis marker protein 8; PFAM: Uncharacterized protein conserved in archaea (DUF2099); TIGRFAM: putative methanogenesis marker protein 8. (286 aa)
AGB02737.1Putative sugar kinase; PFAM: GHMP kinases N terminal domain; TIGRFAM: beta-RFAP synthase. (359 aa)
cbiA-3Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (457 aa)
AGB02772.1PFAM: Nitrogenase component 1 type Oxidoreductase; TIGRFAM: putative methanogenesis marker 13 metalloprotein. (354 aa)
AGB02773.1Hypothetical protein. (406 aa)
AGB02774.1Hypothetical protein; PFAM: CbiX. (132 aa)
AGB02775.1Holliday junction resolvase. (150 aa)
AGB02776.1Putative methanogenesis marker domain 9; PFAM: Dihydrouridine synthase (Dus); TIGRFAM: TIM-barrel protein, putative; putative methanogenesis marker domain 9. (379 aa)
AGB02777.1Triphosphoribosyl-dephospho-CoA synthetase; PFAM: ATP:dephospho-CoA triphosphoribosyl transferase. (273 aa)
AGB02778.1PFAM: Protein of unknown function (DUF447). (188 aa)
AGB02900.1Putative ATP-utilizing enzyme (ATP-grasp superfamily); PFAM: ATP-grasp domain. (295 aa)
AGB02901.1PFAM: Hydantoinase/oxoprolinase; TIGRFAM: probable H4MPT-linked C1 transfer pathway protein. (313 aa)
AGB02987.1PFAM: FTR, proximal lobe; lobe; TIGRFAM: formylmethanofuran--tetrahydromethanopterin N-formyltransferase. (296 aa)
AGB03312.1Putative methanogenesis marker protein 2; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: putative methanogenesis marker protein 2. (349 aa)
AGB03313.1TIGRFAM: putative methanogen marker protein 4. (254 aa)
AGB03314.1Histones H3 and H4; PFAM: Histone-like transcription factor (CBF/NF-Y) and archaeal histone. (68 aa)
AGB03409.1Putative transcriptional regulator with an HTH domain; PFAM: Helix-turn-helix. (177 aa)
AGB03467.1Putative methanogenesis marker protein 8; PFAM: Uncharacterized protein conserved in archaea (DUF2099); TIGRFAM: putative methanogenesis marker protein 8. (288 aa)
mchMethenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (314 aa)
AGB03531.1TIGRFAM: putative methanogenesis marker protein 12; Belongs to the UPF0285 family. (290 aa)
ftrFormylmethanofuran--tetrahydromethanopterin N-formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family. (294 aa)
AGB03591.1Hypothetical protein; Manually curated. (88 aa)
AGB03592.1PFAM: 4Fe-4S binding domain. (408 aa)
AGB03593.1TIGRFAM: CoB--CoM heterodisulfide reductase, subunit C. (193 aa)
AGB03594.1PFAM: Cysteine-rich domain; TIGRFAM: CoB--CoM heterodisulfide reductase, subunit B. (307 aa)
AGB03595.1Polyferredoxin, heterodixulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (725 aa)
AGB03596.1PFAM: Methyl-viologen-reducing hydrogenase, delta subunit. (157 aa)
AGB03597.1PFAM: Methyl-coenzyme M reductase beta subunit, C-terminal domain; Methyl-coenzyme M reductase beta subunit, N-terminal domain; TIGRFAM: methyl-coenzyme M reductase, beta subunit. (437 aa)
AGB03598.1PFAM: Methyl-coenzyme M reductase operon protein D; TIGRFAM: methyl-coenzyme M reductase operon protein D. (156 aa)
AGB03599.1PFAM: Methyl-coenzyme M reductase operon protein C; TIGRFAM: methyl-coenzyme M reductase I operon protein C. (211 aa)
AGB03600.1PFAM: Methyl-coenzyme M reductase gamma subunit; TIGRFAM: methyl-coenzyme M reductase, gamma subunit. (255 aa)
AGB03601.1Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (562 aa)
mtrEN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (299 aa)
mtrDN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (278 aa)
mtrCN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit C; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (282 aa)
mtrBTetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. (97 aa)
mtrAN5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (240 aa)
AGB03611.1PFAM: Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF); TIGRFAM: tetrahydromethanopterin S-methyltransferase, F subunit; manually curated. (67 aa)
mtrA-2Tetrahydromethanopterin S-methyltransferase subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family. (245 aa)
AGB03613.1PFAM: Tetrahydromethanopterin S-methyltransferase MtrH subunit; TIGRFAM: N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H. (345 aa)
mtdCoenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT. (279 aa)
mer5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. (328 aa)
AGB03682.1Putative kinase, aspartokinase/uridylate kinase. (204 aa)
AGB03698.1PFAM: Nickel-dependent hydrogenase; TIGRFAM: coenzyme F420 hydrogenase, subunit alpha; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (455 aa)
AGB03699.1PFAM: Hydrogenase maturation protease; TIGRFAM: coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); hydrogenase maturation protease. (176 aa)
AGB03700.1Coenzyme F420 hydrogenase, subunit gamma; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; 4Fe-4S binding domain; TIGRFAM: coenzyme F420 hydrogenase, subunit gamma. (287 aa)
AGB03701.1PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; TIGRFAM: coenzyme F420 hydrogenase, subunit beta. (308 aa)
AGB03879.1Dihydropteroate synthase-like enzyme; TIGRFAM: dihydropteroate synthase-related protein. (470 aa)
Your Current Organism:
Methanoregula formicica
NCBI taxonomy Id: 593750
Other names: M. formicica SMSP, Methanomicrobiales archaeon SMSP, Methanoregula formicica SMSP, Methanoregula formicica str. SMSP, Methanoregula formicica strain SMSP
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