STRINGSTRING
AGB03730.1 AGB03730.1 argC argC AGB01186.1 AGB01186.1 gap gap AGB01460.1 AGB01460.1 AGB01501.1 AGB01501.1 AGB01503.1 AGB01503.1 AGB01511.1 AGB01511.1 AGB01515.1 AGB01515.1 folD folD AGB01651.1 AGB01651.1 AGB01921.1 AGB01921.1 AGB01923.1 AGB01923.1 AGB02059.1 AGB02059.1 AGB02064.1 AGB02064.1 AGB02190.1 AGB02190.1 AGB02274.1 AGB02274.1 AGB02303.1 AGB02303.1 AGB02339.1 AGB02339.1 AGB02340.1 AGB02340.1 AGB02342.1 AGB02342.1 AGB02345.1 AGB02345.1 AGB02373.1 AGB02373.1 AGB02453.1 AGB02453.1 AGB02456.1 AGB02456.1 AGB02458.1 AGB02458.1 AGB02534.1 AGB02534.1 AGB02622.1 AGB02622.1 aroE aroE AGB02643.1 AGB02643.1 AGB02693.1 AGB02693.1 AGB02699.1 AGB02699.1 AGB02767.1 AGB02767.1 AGB02795.1 AGB02795.1 dapB dapB hemA hemA AGB02871.1 AGB02871.1 AGB02894.1 AGB02894.1 AGB02964.1 AGB02964.1 ala ala AGB03170.1 AGB03170.1 sucD sucD AGB03530.1 AGB03530.1 AGB03540.1 AGB03540.1 nadX nadX AGB03685.1 AGB03685.1 ilvC ilvC AGB03876.1 AGB03876.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGB03730.1Kef-type K+ transport system, membrane component; PFAM: TrkA-N domain; Sodium/hydrogen exchanger family; TrkA-C domain. (665 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase, common form; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (328 aa)
AGB01186.1Putative UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; TIGRFAM: nucleotide sugar dehydrogenase. (281 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II. (347 aa)
AGB01460.1Exopolyphosphatase-like enzyme; PFAM: DHH family; DHHA1 domain; TrkA-N domain. (490 aa)
AGB01501.1PFAM: NAD dependent epimerase/dehydratase family. (346 aa)
AGB01503.1Nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; TIGRFAM: nucleotide sugar dehydrogenase. (457 aa)
AGB01511.1PFAM: NAD dependent epimerase/dehydratase family. (327 aa)
AGB01515.1Nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; TIGRFAM: nucleotide sugar dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (396 aa)
folD5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
AGB01651.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase. (588 aa)
AGB01921.1Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase family protein; PFAM: H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase; TIGRFAM: H2-forming N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase-related protein. (341 aa)
AGB01923.1Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase; PFAM: H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase; TIGRFAM: 5,10-methenyltetrahydromethanopterin hydrogenase. (345 aa)
AGB02059.1Kef-type K+ transport system, predicted NAD-binding component; PFAM: TrkA-N domain; Sodium/hydrogen exchanger family; TrkA-C domain; TIGRFAM: transporter, monovalent cation:proton antiporter-2 (CPA2) family. (672 aa)
AGB02064.1K+ transport system, NAD-binding component; PFAM: TrkA-N domain; TrkA-C domain. (222 aa)
AGB02190.1Nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; TIGRFAM: nucleotide sugar dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (415 aa)
AGB02274.1PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (450 aa)
AGB02303.1Kef-type K+ transport system, predicted NAD-binding component; PFAM: TrkA-N domain; TrkA-C domain; Sodium/hydrogen exchanger family; TIGRFAM: transporter, monovalent cation:proton antiporter-2 (CPA2) family. (668 aa)
AGB02339.1Putative nucleoside-diphosphate sugar epimerase; PFAM: Polysaccharide biosynthesis protein. (329 aa)
AGB02340.1PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: dTDP-glucose 4,6-dehydratase. (313 aa)
AGB02342.1dTDP-4-dehydrorhamnose reductase; PFAM: RmlD substrate binding domain; TIGRFAM: dTDP-4-dehydrorhamnose reductase. (313 aa)
AGB02345.1Putative nucleoside-diphosphate sugar epimerase; PFAM: Polysaccharide biosynthesis protein. (341 aa)
AGB02373.1PFAM: NADP oxidoreductase coenzyme F420-dependent; TIGRFAM: NADPH-dependent F420 reductase. (216 aa)
AGB02453.1Nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; TIGRFAM: nucleotide sugar dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (477 aa)
AGB02456.1Putative dehydrogenase; PFAM: Oxidoreductase family, NAD-binding Rossmann fold. (325 aa)
AGB02458.1PFAM: NAD dependent epimerase/dehydratase family. (313 aa)
AGB02534.1PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain. (328 aa)
AGB02622.1PFAM: Prephenate dehydrogenase. (274 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (463 aa)
AGB02643.1acyl-CoA synthetase (NDP forming); PFAM: CoA binding domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain. (688 aa)
AGB02693.1PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain. (410 aa)
AGB02699.1NAD/NADP transhydrogenase alpha subunit; PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: NAD(P) transhydrogenase, alpha subunit. (397 aa)
AGB02767.1Short-chain alcohol dehydrogenase; PFAM: short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (271 aa)
AGB02795.1PFAM: Semialdehyde dehydrogenase, dimerisation domain; Semialdehyde dehydrogenase, NAD binding domain; TIGRFAM: aspartate-semialdehyde dehydrogenase (non-peptidoglycan organisms). (339 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (254 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (425 aa)
AGB02871.1TIGRFAM: siroheme synthase, N-terminal domain. (208 aa)
AGB02894.1acyl-CoA synthetase (NDP forming); PFAM: CoA binding domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain. (684 aa)
AGB02964.1Dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like protein; PFAM: short chain dehydrogenase. (279 aa)
alaPutative ornithine cyclodeaminase, mu-crystallin; Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate; Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily. (311 aa)
AGB03170.1PFAM: lactate/malate dehydrogenase, alpha/beta C-terminal domain; lactate/malate dehydrogenase, NAD binding domain; Belongs to the LDH/MDH superfamily. (288 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
AGB03530.1PFAM: NAD dependent epimerase/dehydratase family. (311 aa)
AGB03540.1Adenosylhomocysteinase; PFAM: S-adenosyl-L-homocysteine hydrolase, NAD binding domain; S-adenosyl-L-homocysteine hydrolase; TIGRFAM: adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (408 aa)
nadXAspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (252 aa)
AGB03685.1PFAM: lactate/malate dehydrogenase, alpha/beta C-terminal domain; lactate/malate dehydrogenase, NAD binding domain; Belongs to the LDH/MDH superfamily. (318 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa)
AGB03876.1PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain. (404 aa)
Your Current Organism:
Methanoregula formicica
NCBI taxonomy Id: 593750
Other names: M. formicica SMSP, Methanomicrobiales archaeon SMSP, Methanoregula formicica SMSP, Methanoregula formicica str. SMSP, Methanoregula formicica strain SMSP
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