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| | HACD1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (202 aa) |
| | SMPD4 | Sphingomyelin phosphodiesterase 4. (839 aa) |
| | B3GALT2 | Hexosyltransferase. (417 aa) |
| | NEU2 | Neuraminidase 2. (379 aa) |
| | G1Q522_MYOLU | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (601 aa) |
| | GAL3ST4 | Galactose-3-O-sulfotransferase 4. (491 aa) |
| | SPTLC2 | Serine palmitoyltransferase long chain base subunit 2. (561 aa) |
| | PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. (136 aa) |
| | CYP4F22 | Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (536 aa) |
| | DEGS1 | Delta 4-desaturase, sphingolipid 1. (323 aa) |
| | PIGT | Phosphatidylinositol glycan anchor biosynthesis class T. (582 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (660 aa) |
| | PIGO | Phosphatidylinositol glycan anchor biosynthesis class O. (1096 aa) |
| | ENPP2 | Ectonucleotide pyrophosphatase/phosphodiesterase 2. (891 aa) |
| | B4GALT5 | Beta-1,4-galactosyltransferase 5. (361 aa) |
| | NAGA | Alpha-galactosidase. (417 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (314 aa) |
| | PIGS | Phosphatidylinositol glycan anchor biosynthesis class S. (555 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (652 aa) |
| | PIGG | Phosphatidylinositol glycan anchor biosynthesis class G. (752 aa) |
| | SPHK2 | DAGKc domain-containing protein. (758 aa) |
| | UGT8 | UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family. (540 aa) |
| | ZPBP2 | Zona pellucida binding protein 2. (327 aa) |
| | LOC102418309 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (573 aa) |
| | LOC102431153 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (591 aa) |
| | UGCG | UDP-glucose ceramide glucosyltransferase. (394 aa) |
| | NAAA | N-acylethanolamine acid amidase; Belongs to the acid ceramidase family. (328 aa) |
| | AGK | Acylglycerol kinase. (421 aa) |
| | SAMD8 | Sterile alpha motif domain containing 8. (421 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa) |
| | ALOX12B | Arachidonate 12-lipoxygenase, 12R type. (701 aa) |
| | ALOXE3 | Arachidonate lipoxygenase 3. (852 aa) |
| | TECR | Trans-2,3-enoyl-CoA reductase. (308 aa) |
| | PIGF | Phosphatidylinositol glycan anchor biosynthesis class F. (219 aa) |
| | MGST2 | Microsomal glutathione S-transferase 2. (146 aa) |
| | ITGB8 | Integrin beta; Belongs to the integrin beta chain family. (769 aa) |
| | TLCD3B | TLC domain containing 3B. (228 aa) |
| | SMPDL3A | Acid sphingomyelinase-like phosphodiesterase. (453 aa) |
| | CLN6 | CLN6 transmembrane ER protein. (305 aa) |
| | SPHK1 | Sphingosine kinase 1. (467 aa) |
| | PIGB | Mannosyltransferase. (540 aa) |
| | GBA3 | Glucosylceramidase beta 3 (gene/pseudogene); Belongs to the glycosyl hydrolase 1 family. (383 aa) |
| | ELOVL2 | Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (295 aa) |
| | G1PDT2_MYOLU | Mannosyltransferase. (529 aa) |
| | G1PEF0_MYOLU | COesterase domain-containing protein. (336 aa) |
| | ASAH1 | N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa) |
| | PIGQ | Phosphatidylinositol glycan anchor biosynthesis class Q. (631 aa) |
| | CERS2 | Ceramide synthase 2. (380 aa) |
| | ST3GAL3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (278 aa) |
| | DEGS2 | Delta 4-desaturase, sphingolipid 2. (323 aa) |
| | PGAP1 | GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (922 aa) |
| | ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (285 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (399 aa) |
| | OSBP | Oxysterol-binding protein; Belongs to the OSBP family. (810 aa) |
| | MPPE1 | Metallophosphoesterase 1. (397 aa) |
| | CWH43 | Cell wall biogenesis 43 C-terminal homolog. (695 aa) |
| | ELOVL7 | Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (281 aa) |
| | GBA2 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (930 aa) |
| | B4GALT4 | Beta-1,4-galactosyltransferase 4. (344 aa) |
| | HACD2 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (165 aa) |
| | ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (333 aa) |
| | G1PPL1_MYOLU | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (132 aa) |
| | ORMDL1 | ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa) |
| | ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6; Belongs to the glycosyltransferase 29 family. (330 aa) |
| | GAL3ST3 | Uncharacterized protein. (189 aa) |
| | PLPP2 | Phospholipid phosphatase 2. (288 aa) |
| | G1Q033_MYOLU | COesterase domain-containing protein. (503 aa) |
| | G1PZV1_MYOLU | TLC domain-containing protein. (196 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (341 aa) |
| | RGSL1 | Regulator of G protein signaling like 1. (1079 aa) |
| | ENPP7 | Ectonucleotide pyrophosphatase/phosphodiesterase 7. (443 aa) |
| | SCCPDH | Saccharopine dehydrogenase (putative). (432 aa) |
| | PIGA | Phosphatidylinositol glycan anchor biosynthesis class A. (484 aa) |
| | PLPP3 | acidPPc domain-containing protein. (265 aa) |
| | PIGC | Phosphatidylinositol glycan anchor biosynthesis class C. (297 aa) |
| | G1PVE2_MYOLU | Neutral ceramidase. (483 aa) |
| | P2RX1 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (590 aa) |
| | GALC | Galactosylceramidase. (685 aa) |
| | AGMO | Alkylglycerol monooxygenase; Belongs to the sterol desaturase family. (445 aa) |
| | ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (239 aa) |
| | ST8SIA4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (455 aa) |
| | G1PPK1_MYOLU | DAGKc domain-containing protein. (241 aa) |
| | ABCA12 | ATP binding cassette subfamily A member 12. (2532 aa) |
| | SPTSSA | Serine palmitoyltransferase small subunit A. (68 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (527 aa) |
| | DPM2 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family. (84 aa) |
| | ST6GALNAC4 | Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (301 aa) |
| | G1PN15_MYOLU | Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (328 aa) |
| | GBA | Glucosylceramidase. (536 aa) |
| | SERINC5 | Serine incorporator 5. (461 aa) |
| | PIGW | Phosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (502 aa) |
| | CERS6 | Ceramide synthase 6. (249 aa) |
| | PSAP | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. (523 aa) |
| | PGAP2 | Post-GPI attachment to proteins 2. (254 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (567 aa) |
| | G1PU70_MYOLU | Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (333 aa) |
| | PIGN | Phosphatidylinositol glycan anchor biosynthesis class N. (930 aa) |
| | DPM1 | Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. (296 aa) |
| | ST6GALNAC5 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Belongs to the glycosyltransferase 29 family. (250 aa) |
| | ST3GAL2 | ST3 beta-galactoside alpha-2,3-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (350 aa) |
| | KDSR | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa) |
| | SERINC2 | Serine incorporator 2. (496 aa) |
| | SGMS2 | Sphingomyelin synthase 2. (365 aa) |
| | HEXA | Beta-hexosaminidase. (531 aa) |
| | TMPPE | Transmembrane protein with metallophosphoesterase domain. (448 aa) |
| | NEU3 | Neuraminidase 3. (427 aa) |
| | PGAP3 | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (324 aa) |
| | CERK | DAGKc domain-containing protein. (294 aa) |
| | HACD3 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (365 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa) |
| | PNPLA1 | Patatin like phospholipase domain containing 1. (509 aa) |
| | SGMS1 | Sphingomyelin synthase 1. (419 aa) |
| | SPTLC3 | Serine palmitoyltransferase long chain base subunit 3. (514 aa) |
| | PLPP1 | Phospholipid phosphatase 1. (267 aa) |
| | SPTSSB | Serine palmitoyltransferase small subunit B. (76 aa) |
| | PIGM | GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. (423 aa) |
| | ST8SIA2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (375 aa) |
| | SERINC3 | Serine incorporator 3. (473 aa) |
| | SERINC1 | Serine incorporator 1. (453 aa) |
| | KIT | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa) |
| | PIGV | GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (493 aa) |
| | B4GALNT1 | Beta-1,4 N-acetylgalactosaminyltransferase. (533 aa) |
| | PLA2G15 | Phospholipase A2 group XV. (408 aa) |
| | CERS3 | Ceramide synthase 3. (389 aa) |
| | CERS4 | Ceramide synthase 4. (390 aa) |
| | TMEM130 | Transmembrane protein 130. (402 aa) |
| | GM2A | GM2 ganglioside activator. (196 aa) |
| | ORMDL3 | ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa) |
| | GAL3ST2 | Galactose-3-O-sulfotransferase 2. (394 aa) |
| | NEU4 | Neuraminidase 4. (498 aa) |
| | ORMDL2 | ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa) |
| | B4GALT6 | Beta-1,4-galactosyltransferase 6. (382 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | HACD4 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (230 aa) |
| | SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (476 aa) |
| | PIGL | Phosphatidylinositol glycan anchor biosynthesis class L. (252 aa) |
| | DPM3 | Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family. (111 aa) |
| | CERT1 | Ceramide transporter 1. (756 aa) |
| | ARV1 | ARV1 homolog, fatty acid homeostasis modulator. (283 aa) |
| | GLA | Alpha-galactosidase. (432 aa) |
| | FUT9 | Fucosyltransferase 9. (359 aa) |
| | PIGH | Phosphatidylinositol glycan anchor biosynthesis class H. (188 aa) |
| | B4GALT3 | Beta-1,4-galactosyltransferase 3. (398 aa) |
| | HEXB | Hexosaminidase subunit beta. (456 aa) |
| | PIGU | Phosphatidylinositol glycan anchor biosynthesis class U. (435 aa) |
| | NEU1 | Neuraminidase 1. (416 aa) |
| | SPNS2 | Sphingolipid transporter 2. (550 aa) |
| | ST8SIA3 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (478 aa) |
| | CERS5 | Ceramide synthase 5. (335 aa) |
| | ELOVL6 | Elongation of very long chain fatty acids protein. (192 aa) |
| | G1QF63_MYOLU | Uncharacterized protein. (234 aa) |
| | LOC102433448 | L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (348 aa) |
| | ELOVL3 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa) |
| | B3GALT4 | Hexosyltransferase. (384 aa) |
| | SMPDL3B | Acid sphingomyelinase-like phosphodiesterase. (456 aa) |
| | G1QCQ6_MYOLU | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa) |
| | LOC102439756 | Uncharacterized protein. (457 aa) |
| | ELOVL4 | Elongation of very long chain fatty acids protein. (296 aa) |
| | PIGK | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (395 aa) |
| | PYURF | PIGY upstream reading frame. (114 aa) |
| | LOC102425138 | L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (356 aa) |
| | G1QA34_MYOLU | Uncharacterized protein. (359 aa) |
| | G1Q8Z0_MYOLU | Uncharacterized protein. (269 aa) |
| | LOC102442628 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (602 aa) |
| | PIGX | Phosphatidylinositol glycan anchor biosynthesis class X. (258 aa) |
| | G1Q8B0_MYOLU | Neutral ceramidase. (403 aa) |
| | ENSMLUP00000019696 | annotation not available (58 aa) |
| | PIGY | Uncharacterized protein. (71 aa) |
