node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT1S1 | C12orf66 | ENSMLUP00000015623 | ENSMLUP00000008751 | AKT1 substrate 1. | Chromosome 12 open reading frame 66. | 0.476 |
AKT1S1 | DEPTOR | ENSMLUP00000015623 | ENSMLUP00000008776 | AKT1 substrate 1. | DEP domain containing MTOR interacting protein. | 0.950 |
AKT1S1 | G1PV13_MYOLU | ENSMLUP00000015623 | ENSMLUP00000015153 | AKT1 substrate 1. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.567 |
AKT1S1 | ITFG2 | ENSMLUP00000015623 | ENSMLUP00000009486 | AKT1 substrate 1. | Integrin alpha FG-GAP repeat containing 2. | 0.482 |
AKT1S1 | PRKAA1 | ENSMLUP00000015623 | ENSMLUP00000012958 | AKT1 substrate 1. | Non-specific serine/threonine protein kinase. | 0.888 |
AKT1S1 | PRKAA2 | ENSMLUP00000015623 | ENSMLUP00000012975 | AKT1 substrate 1. | Non-specific serine/threonine protein kinase. | 0.884 |
AKT1S1 | STK11 | ENSMLUP00000015623 | ENSMLUP00000013647 | AKT1 substrate 1. | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. | 0.504 |
AKT1S1 | TSC1 | ENSMLUP00000015623 | ENSMLUP00000006081 | AKT1 substrate 1. | TSC complex subunit 1. | 0.468 |
AKT1S1 | TSC2 | ENSMLUP00000015623 | ENSMLUP00000003872 | AKT1 substrate 1. | TSC complex subunit 2. | 0.487 |
BMT2 | C12orf66 | ENSMLUP00000020829 | ENSMLUP00000008751 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Chromosome 12 open reading frame 66. | 0.965 |
BMT2 | CASTOR1 | ENSMLUP00000020829 | ENSMLUP00000001939 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Cytosolic arginine sensor for mTORC1 subunit 1. | 0.715 |
BMT2 | CASTOR2 | ENSMLUP00000020829 | ENSMLUP00000013640 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Uncharacterized protein. | 0.640 |
BMT2 | DEPTOR | ENSMLUP00000020829 | ENSMLUP00000008776 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | DEP domain containing MTOR interacting protein. | 0.572 |
BMT2 | FLCN | ENSMLUP00000020829 | ENSMLUP00000014418 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Folliculin. | 0.476 |
BMT2 | FNIP1 | ENSMLUP00000020829 | ENSMLUP00000017131 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Folliculin interacting protein 1. | 0.452 |
BMT2 | G1NVD4_MYOLU | ENSMLUP00000020829 | ENSMLUP00000001225 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | DEP domain-containing protein. | 0.948 |
BMT2 | G1QEH5_MYOLU | ENSMLUP00000020829 | ENSMLUP00000022108 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Uncharacterized protein. | 0.889 |
BMT2 | ITFG2 | ENSMLUP00000020829 | ENSMLUP00000009486 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Integrin alpha FG-GAP repeat containing 2. | 0.948 |
BMT2 | KPTN | ENSMLUP00000020829 | ENSMLUP00000011527 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Kaptin, actin binding protein. | 0.946 |
BMT2 | NPRL2 | ENSMLUP00000020829 | ENSMLUP00000002284 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR2 like, GATOR1 complex subunit. | 0.913 |