STRINGSTRING
SIRT1 SIRT1 TSC2 TSC2 NPRL2 NPRL2 SESN2 SESN2 TBC1D7 TBC1D7 G1NVD4_MYOLU G1NVD4_MYOLU RNF152 RNF152 HIF1A HIF1A STK11 STK11 CASTOR2 CASTOR2 SESN3 SESN3 ENDOG ENDOG PRKAA2 PRKAA2 PRKAA1 PRKAA1 DEPTOR DEPTOR SZT2 SZT2 KPTN KPTN SH3BP4 SH3BP4 TMEM127 TMEM127 G1PHV0_MYOLU G1PHV0_MYOLU MTM1 MTM1 UBR1 UBR1 ITFG2 ITFG2 G1QG66_MYOLU G1QG66_MYOLU G1QEH5_MYOLU G1QEH5_MYOLU BMT2 BMT2 G1Q5Z9_MYOLU G1Q5Z9_MYOLU DDIT4 DDIT4 FNIP1 FNIP1 UBR2 UBR2 AKT1S1 AKT1S1 G1PV13_MYOLU G1PV13_MYOLU FLCN FLCN CASTOR1 CASTOR1 NPRL3 NPRL3 MAPKAPK5 MAPKAPK5 C12orf66 C12orf66 SESN1 SESN1 TSC1 TSC1 MINAR1 MINAR1 TNFAIP8L1 TNFAIP8L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRT1Sirtuin 1. (610 aa)
TSC2TSC complex subunit 2. (1809 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (273 aa)
SESN2Sestrin 2. (489 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
G1NVD4_MYOLUDEP domain-containing protein. (1418 aa)
RNF152Ring finger protein 152. (203 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (826 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (441 aa)
CASTOR2Uncharacterized protein. (298 aa)
SESN3Sestrin 3. (470 aa)
ENDOGEndonuclease. (294 aa)
PRKAA2Non-specific serine/threonine protein kinase. (528 aa)
PRKAA1Non-specific serine/threonine protein kinase. (517 aa)
DEPTORDEP domain containing MTOR interacting protein. (370 aa)
SZT2SZT2 subunit of KICSTOR complex. (3430 aa)
KPTNKaptin, actin binding protein. (436 aa)
SH3BP4SH3 domain binding protein 4. (955 aa)
TMEM127Transmembrane protein 127. (238 aa)
G1PHV0_MYOLUFAT domain-containing protein. (2192 aa)
MTM1Myotubularin 1. (603 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1754 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (444 aa)
G1QG66_MYOLUUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1083 aa)
G1QEH5_MYOLUUncharacterized protein. (132 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (352 aa)
G1Q5Z9_MYOLUUncharacterized protein. (193 aa)
DDIT4DNA damage inducible transcript 4. (198 aa)
FNIP1Folliculin interacting protein 1. (1135 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
AKT1S1AKT1 substrate 1. (253 aa)
G1PV13_MYOLUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (477 aa)
FLCNFolliculin. (576 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (331 aa)
NPRL3Uncharacterized protein. (441 aa)
MAPKAPK5Protein kinase domain-containing protein. (463 aa)
C12orf66Chromosome 12 open reading frame 66. (444 aa)
SESN1Sestrin 1. (492 aa)
TSC1TSC complex subunit 1. (1167 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (935 aa)
TNFAIP8L1TNF alpha induced protein 8 like 1. (211 aa)
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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