41 items (Myotis lucifugus) - STRING interaction network

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	TSC2	TSC complex subunit 2. (1809 aa)
	NPRL2	NPR2 like, GATOR1 complex subunit. (273 aa)
	CASTOR1	Cytosolic arginine sensor for mTORC1 subunit 1. (331 aa)
	TBC1D7	TBC1 domain family member 7. (293 aa)
	G1NVD4_MYOLU	DEP domain-containing protein. (1418 aa)
	G1QG66_MYOLU	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1083 aa)
	G1QEH5_MYOLU	Uncharacterized protein. (132 aa)
	BMT2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (352 aa)
	G1Q5Z9_MYOLU	Uncharacterized protein. (193 aa)
	DDIT4	DNA damage inducible transcript 4. (198 aa)
	FNIP1	Folliculin interacting protein 1. (1135 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
	AKT1S1	AKT1 substrate 1. (253 aa)
	G1PV13_MYOLU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (477 aa)
	FLCN	Folliculin. (576 aa)
	MAPKAPK5	Protein kinase domain-containing protein. (463 aa)
	NPRL3	Uncharacterized protein. (441 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (826 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (441 aa)
	CASTOR2	Uncharacterized protein. (298 aa)
	SESN3	Sestrin 3. (470 aa)
	ENDOG	Endonuclease. (294 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (528 aa)
	G1PHV0_MYOLU	FAT domain-containing protein. (2192 aa)
	TMEM127	Transmembrane protein 127. (238 aa)
	SH3BP4	SH3 domain binding protein 4. (955 aa)
	RNF152	Ring finger protein 152. (203 aa)
	SESN2	Sestrin 2. (489 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (370 aa)
	C12orf66	Chromosome 12 open reading frame 66. (444 aa)
	ITFG2	Integrin alpha FG-GAP repeat containing 2. (444 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1754 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (517 aa)
	SZT2	SZT2 subunit of KICSTOR complex. (3430 aa)
	KPTN	Kaptin, actin binding protein. (436 aa)
	MTM1	Myotubularin 1. (603 aa)
	SESN1	Sestrin 1. (492 aa)
	TSC1	TSC complex subunit 1. (1167 aa)
	MINAR1	Membrane integral NOTCH2 associated receptor 1. (935 aa)
	TNFAIP8L1	TNF alpha induced protein 8 like 1. (211 aa)
	SIRT1	Sirtuin 1. (610 aa)

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1S1	C12orf66	ENSMLUP00000015623	ENSMLUP00000008751	AKT1 substrate 1.	Chromosome 12 open reading frame 66.	0.476
AKT1S1	DEPTOR	ENSMLUP00000015623	ENSMLUP00000008776	AKT1 substrate 1.	DEP domain containing MTOR interacting protein.	0.950
AKT1S1	G1PV13_MYOLU	ENSMLUP00000015623	ENSMLUP00000015153	AKT1 substrate 1.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.567
AKT1S1	ITFG2	ENSMLUP00000015623	ENSMLUP00000009486	AKT1 substrate 1.	Integrin alpha FG-GAP repeat containing 2.	0.482
AKT1S1	PRKAA1	ENSMLUP00000015623	ENSMLUP00000012958	AKT1 substrate 1.	Non-specific serine/threonine protein kinase.	0.888
AKT1S1	PRKAA2	ENSMLUP00000015623	ENSMLUP00000012975	AKT1 substrate 1.	Non-specific serine/threonine protein kinase.	0.884
AKT1S1	STK11	ENSMLUP00000015623	ENSMLUP00000013647	AKT1 substrate 1.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.504
AKT1S1	TSC1	ENSMLUP00000015623	ENSMLUP00000006081	AKT1 substrate 1.	TSC complex subunit 1.	0.468
AKT1S1	TSC2	ENSMLUP00000015623	ENSMLUP00000003872	AKT1 substrate 1.	TSC complex subunit 2.	0.487
BMT2	C12orf66	ENSMLUP00000020829	ENSMLUP00000008751	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Chromosome 12 open reading frame 66.	0.965
BMT2	CASTOR1	ENSMLUP00000020829	ENSMLUP00000001939	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Cytosolic arginine sensor for mTORC1 subunit 1.	0.715
BMT2	CASTOR2	ENSMLUP00000020829	ENSMLUP00000013640	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Uncharacterized protein.	0.640
BMT2	DEPTOR	ENSMLUP00000020829	ENSMLUP00000008776	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	DEP domain containing MTOR interacting protein.	0.572
BMT2	FLCN	ENSMLUP00000020829	ENSMLUP00000014418	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Folliculin.	0.476
BMT2	FNIP1	ENSMLUP00000020829	ENSMLUP00000017131	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Folliculin interacting protein 1.	0.452
BMT2	G1NVD4_MYOLU	ENSMLUP00000020829	ENSMLUP00000001225	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	DEP domain-containing protein.	0.948
BMT2	G1QEH5_MYOLU	ENSMLUP00000020829	ENSMLUP00000022108	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Uncharacterized protein.	0.889
BMT2	ITFG2	ENSMLUP00000020829	ENSMLUP00000009486	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Integrin alpha FG-GAP repeat containing 2.	0.948
BMT2	KPTN	ENSMLUP00000020829	ENSMLUP00000011527	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Kaptin, actin binding protein.	0.946
BMT2	NPRL2	ENSMLUP00000020829	ENSMLUP00000002284	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR2 like, GATOR1 complex subunit.	0.913