STRINGSTRING
IMPACT IMPACT PRKAA1 PRKAA1 SH3GLB1 SH3GLB1 ITFG2 ITFG2 NIM1K NIM1K RRP8 RRP8 G1Q8T5_MYOLU G1Q8T5_MYOLU ZC3H12A ZC3H12A G1QCQ8_MYOLU G1QCQ8_MYOLU TBL2 TBL2 PLIN2 PLIN2 PRKAG1 PRKAG1 NUAK2 NUAK2 PLIN3 PLIN3 PICK1 PICK1 SIK1 SIK1 SESN3 SESN3 PIK3C3 PIK3C3 PRKAA2 PRKAA2 SESN2 SESN2 G1NW95_MYOLU G1NW95_MYOLU FOXO3 FOXO3 NFE2L2 NFE2L2 BECN1 BECN1 PRKAG3 PRKAG3 SIRT1 SIRT1 PRKAG2 PRKAG2 MTMR3 MTMR3 ATG14 ATG14 MYBBP1A MYBBP1A KPTN KPTN TP53 TP53 ASNS ASNS SESN1 SESN1 NUAK1 NUAK1 PMAIP1 PMAIP1 KAT5 KAT5 HSPA5 HSPA5 C12orf66 C12orf66 ATF4 ATF4 G1PZ51_MYOLU G1PZ51_MYOLU BHLHA15 BHLHA15 EIF2AK3 EIF2AK3 SIK2 SIK2 SZT2 SZT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IMPACTImpact RWD domain protein. (228 aa)
PRKAA1Non-specific serine/threonine protein kinase. (517 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (364 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (444 aa)
NIM1KNIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (436 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (501 aa)
G1Q8T5_MYOLUUncharacterized protein. (80 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (591 aa)
G1QCQ8_MYOLUUncharacterized protein. (333 aa)
TBL2Transducin beta like 2. (446 aa)
PLIN2Perilipin; Belongs to the perilipin family. (451 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
NUAK2NUAK family kinase 2. (657 aa)
PLIN3Perilipin; Belongs to the perilipin family. (436 aa)
PICK1Protein interacting with PRKCA 1. (413 aa)
SIK1Uncharacterized protein. (783 aa)
SESN3Sestrin 3. (470 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (889 aa)
PRKAA2Non-specific serine/threonine protein kinase. (528 aa)
SESN2Sestrin 2. (489 aa)
G1NW95_MYOLUBZIP domain-containing protein. (384 aa)
FOXO3Forkhead box O3. (672 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (603 aa)
BECN1Beclin 1. (448 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (496 aa)
SIRT1Sirtuin 1. (610 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (320 aa)
MTMR3Myotubularin related protein 3. (1201 aa)
ATG14Autophagy related 14. (492 aa)
MYBBP1AMYB binding protein 1a. (1343 aa)
KPTNKaptin, actin binding protein. (436 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (567 aa)
SESN1Sestrin 1. (492 aa)
NUAK1NUAK family kinase 1. (666 aa)
PMAIP1Uncharacterized protein. (54 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (655 aa)
C12orf66Chromosome 12 open reading frame 66. (444 aa)
ATF4BZIP domain-containing protein. (347 aa)
G1PZ51_MYOLUCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
BHLHA15Basic helix-loop-helix family member a15. (187 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1015 aa)
SIK2Salt inducible kinase 2. (918 aa)
SZT2SZT2 subunit of KICSTOR complex. (3430 aa)
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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