(29 nodes) Brain morphogenesis network (Myotis lucifugus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

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co-expression

protein homology

Your Input:
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	BBS4	Bardet-Biedl syndrome 4. (498 aa)
	ZNF335	Zinc finger protein 335. (1351 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (792 aa)
	UCHL5	Ubiquitin carboxyl-terminal hydrolase. (328 aa)
	OTX1	Orthodenticle homeobox 1. (314 aa)
	FOXO3	Forkhead box O3. (672 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (727 aa)
	FANCD2	FA complementation group D2. (1446 aa)
	FBXW11	F-box and WD repeat domain containing 11. (510 aa)
	NF1	Neurofibromin 1. (2842 aa)
	SLC4A10	Anion exchange protein. (1176 aa)
	GSX2	GS homeobox 2. (245 aa)
	HESX1	HESX homeobox 1. (185 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	G1PFG4_MYOLU	Uncharacterized protein. (700 aa)
	GBA	Glucosylceramidase. (536 aa)
	FANCC	FA complementation group C. (476 aa)
	L7N1Q1_MYOLU	Uncharacterized protein. (399 aa)
	VPS51	VPS51 subunit of GARP complex. (781 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
	G1Q1C1_MYOLU	Uncharacterized protein. (55 aa)
	G1Q226_MYOLU	TGF_BETA_2 domain-containing protein. (393 aa)
	ENSMLUP00000018357	annotation not available (56 aa)
	BBS1	BBS1 domain-containing protein. (572 aa)
	ENSMLUP00000020089	annotation not available (33 aa)
	LOC102435223	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (629 aa)
	EMX1	Empty spiracles homeobox 1. (194 aa)

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS1	BBS2	ENSMLUP00000019421	ENSMLUP00000004553	BBS1 domain-containing protein.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS1	BBS4	ENSMLUP00000019421	ENSMLUP00000000158	BBS1 domain-containing protein.	Bardet-Biedl syndrome 4.	0.999
BBS1	MKKS	ENSMLUP00000019421	ENSMLUP00000008557	BBS1 domain-containing protein.	McKusick-Kaufman syndrome.	0.416
BBS1	SMO	ENSMLUP00000019421	ENSMLUP00000000880	BBS1 domain-containing protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.807
BBS2	BBS1	ENSMLUP00000004553	ENSMLUP00000019421	Bardet-Biedl syndrome 2 protein homolog.	BBS1 domain-containing protein.	0.999
BBS2	BBS4	ENSMLUP00000004553	ENSMLUP00000000158	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4.	0.999
BBS2	MKKS	ENSMLUP00000004553	ENSMLUP00000008557	Bardet-Biedl syndrome 2 protein homolog.	McKusick-Kaufman syndrome.	0.567
BBS2	SMO	ENSMLUP00000004553	ENSMLUP00000000880	Bardet-Biedl syndrome 2 protein homolog.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.742
BBS4	BBS1	ENSMLUP00000000158	ENSMLUP00000019421	Bardet-Biedl syndrome 4.	BBS1 domain-containing protein.	0.999
BBS4	BBS2	ENSMLUP00000000158	ENSMLUP00000004553	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS4	NF1	ENSMLUP00000000158	ENSMLUP00000005804	Bardet-Biedl syndrome 4.	Neurofibromin 1.	0.497
BBS4	SMO	ENSMLUP00000000158	ENSMLUP00000000880	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.742
FANCC	FANCD2	ENSMLUP00000012365	ENSMLUP00000005669	FA complementation group C.	FA complementation group D2.	0.991
FANCC	G1Q1C1_MYOLU	ENSMLUP00000012365	ENSMLUP00000017504	FA complementation group C.	Uncharacterized protein.	0.529
FANCD2	FANCC	ENSMLUP00000005669	ENSMLUP00000012365	FA complementation group D2.	FA complementation group C.	0.991
FANCD2	G1Q1C1_MYOLU	ENSMLUP00000005669	ENSMLUP00000017504	FA complementation group D2.	Uncharacterized protein.	0.991
FBXW11	SMO	ENSMLUP00000005761	ENSMLUP00000000880	F-box and WD repeat domain containing 11.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.408
FOXO3	UCHL5	ENSMLUP00000002350	ENSMLUP00000001313	Forkhead box O3.	Ubiquitin carboxyl-terminal hydrolase.	0.513
G1PFG4_MYOLU	L7N1Q1_MYOLU	ENSMLUP00000009312	ENSMLUP00000012755	Uncharacterized protein.	Uncharacterized protein.	0.897
G1PFG4_MYOLU	UCHL5	ENSMLUP00000009312	ENSMLUP00000001313	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.519