STRINGSTRING
MED1 MED1 TP53 TP53 MED16 MED16 ERCC6 ERCC6 HNF1B HNF1B ERCC1 ERCC1 TAF12 TAF12 MED8 MED8 SUB1 SUB1 ESR1 ESR1 LOC102422576 LOC102422576 G1PVA9_MYOLU G1PVA9_MYOLU GTF2A1 GTF2A1 G1PZ51_MYOLU G1PZ51_MYOLU G1PZL5_MYOLU G1PZL5_MYOLU G1Q7H9_MYOLU G1Q7H9_MYOLU G1Q3D2_MYOLU G1Q3D2_MYOLU G1Q2W7_MYOLU G1Q2W7_MYOLU G1Q221_MYOLU G1Q221_MYOLU G1Q1F3_MYOLU G1Q1F3_MYOLU TAF10 TAF10 G1PZQ5_MYOLU G1PZQ5_MYOLU PSMC6 PSMC6 MED4-2 MED4-2 LOC102437556 LOC102437556 G1Q8T5_MYOLU G1Q8T5_MYOLU TAF2 TAF2 TAF4 TAF4 WNT10B WNT10B TAF5 TAF5 MED24 MED24 MED13 MED13 TAF8 TAF8 G1PCP6_MYOLU G1PCP6_MYOLU MED17 MED17 SRF SRF MED30 MED30 DHX36 DHX36 TAF3 TAF3 MED4 MED4 MED14 MED14 MED12 MED12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1575 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (833 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1480 aa)
HNF1BHNF1 homeobox B. (557 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
TAF12TATA-box binding protein associated factor 12. (161 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (268 aa)
SUB1PC4 domain-containing protein. (134 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (551 aa)
LOC102422576Uncharacterized protein. (434 aa)
G1PVA9_MYOLUTAFH domain-containing protein. (747 aa)
GTF2A1Uncharacterized protein. (380 aa)
G1PZ51_MYOLUCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
G1PZL5_MYOLUUncharacterized protein. (693 aa)
G1Q7H9_MYOLUTAF domain-containing protein. (439 aa)
G1Q3D2_MYOLUHomeobox domain-containing protein. (309 aa)
G1Q2W7_MYOLUTAF6_C domain-containing protein. (482 aa)
G1Q221_MYOLUTAF domain-containing protein. (426 aa)
G1Q1F3_MYOLUPC4 domain-containing protein. (134 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (144 aa)
G1PZQ5_MYOLUUncharacterized protein. (371 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
MED4-2Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (234 aa)
LOC102437556TAFH domain-containing protein. (494 aa)
G1Q8T5_MYOLUUncharacterized protein. (80 aa)
TAF2TATA-box binding protein associated factor 2. (1198 aa)
TAF4TATA-box binding protein associated factor 4. (637 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (402 aa)
TAF5TATA-box binding protein associated factor 5. (615 aa)
MED24Mediator complex subunit 24. (925 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2177 aa)
TAF8TATA-box binding protein associated factor 8. (310 aa)
G1PCP6_MYOLUUncharacterized protein. (218 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (652 aa)
SRFSerum response factor. (325 aa)
MED30Mediator complex subunit 30. (149 aa)
DHX36DEAH-box helicase 36. (1005 aa)
TAF3TATA-box binding protein associated factor 3. (796 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (269 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1456 aa)
MED12Mediator complex subunit 12. (2187 aa)
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.