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| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa) |
| | NUAK1 | NUAK family kinase 1. (666 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (221 aa) |
| | MDM4 | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (710 aa) |
| | TPX2 | TPX2 microtubule nucleation factor. (737 aa) |
| | RPA3 | Replication protein A3. (118 aa) |
| | HIPK1 | Homeodomain interacting protein kinase 1. (1213 aa) |
| | AURKC | Aurora kinase C; Belongs to the protein kinase superfamily. (225 aa) |
| | HIPK4 | Homeodomain interacting protein kinase 4. (611 aa) |
| | AURKA | Aurora kinase A; Belongs to the protein kinase superfamily. (408 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | NOC2L | NOC2 like nucleolar associated transcriptional repressor. (701 aa) |
| | TAF13 | Uncharacterized protein. (124 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (163 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2055 aa) |
| | G1PC16_MYOLU | Transcription initiation factor TFIID subunit. (1865 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (756 aa) |
| | G1PCP6_MYOLU | Uncharacterized protein. (218 aa) |
| | G1PD06_MYOLU | Transcription initiation factor TFIID subunit. (1870 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1057 aa) |
| | CSNK2B | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa) |
| | TAF2 | TATA-box binding protein associated factor 2. (1198 aa) |
| | MDM2 | MDM2 proto-oncogene. (499 aa) |
| | CSNK2A1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa) |
| | TAF4 | TATA-box binding protein associated factor 4. (637 aa) |
| | L7N1K2_MYOLU | Uncharacterized protein; Belongs to the cyclin family. (297 aa) |
| | PRKAG1 | Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa) |
| | G1PHV0_MYOLU | FAT domain-containing protein. (2192 aa) |
| | RECQL4 | RecQ like helicase 4. (1228 aa) |
| | NUAK2 | NUAK family kinase 2. (657 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (510 aa) |
| | TP53RK | TP53 regulating kinase. (258 aa) |
| | TAF12 | TATA-box binding protein associated factor 12. (161 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (238 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (596 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (729 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (517 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (528 aa) |
| | G1PQ28_MYOLU | AMPKBI domain-containing protein. (221 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (895 aa) |
| | TAF9B | TATA-box binding protein associated factor 9b. (261 aa) |
| | TBP | TATA-box binding protein. (318 aa) |
| | BLM | BLM RecQ like helicase. (1410 aa) |
| | CDK5 | Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (294 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (441 aa) |
| | HIPK3 | Homeodomain interacting protein kinase 3. (1214 aa) |
| | DNA2 | Uncharacterized protein. (1035 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | PRKAB1 | Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa) |
| | RAD9B | RAD9 checkpoint clamp component B. (328 aa) |
| | TBPL2 | TATA-box binding protein like 2. (356 aa) |
| | MAPKAPK5 | Protein kinase domain-containing protein. (463 aa) |
| | RFC4 | Replication factor C subunit 4. (366 aa) |
| | ANKRD11 | Ankyrin repeat domain 11. (2657 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1316 aa) |
| | CHEK2 | Checkpoint kinase 2. (543 aa) |
| | G1PVA9_MYOLU | TAFH domain-containing protein. (747 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2566 aa) |
| | LOC102420450 | Ubiquitin-like domain-containing protein. (156 aa) |
| | TAF7L | TATA-box binding protein associated factor 7 like. (472 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1190 aa) |
| | ATRIP | ATR interacting protein. (695 aa) |
| | G1PYD9_MYOLU | Ubiquitin-like domain-containing protein. (123 aa) |
| | CDK5R1 | Cyclin-dependent kinase 5 activator. (307 aa) |
| | G1PZ51_MYOLU | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa) |
| | G1Q060_MYOLU | Uncharacterized protein. (121 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (144 aa) |
| | LOC102437265 | Dna2 domain-containing protein. (356 aa) |
| | G1Q221_MYOLU | TAF domain-containing protein. (426 aa) |
| | LOC102429896 | XPGI domain-containing protein. (714 aa) |
| | G1Q2S7_MYOLU | Ubiquitin-like domain-containing protein. (156 aa) |
| | G1Q2W7_MYOLU | TAF6_C domain-containing protein. (482 aa) |
| | G1Q2X3_MYOLU | AAA domain-containing protein. (332 aa) |
| | RMI1 | RecQ mediated genome instability 1. (616 aa) |
| | G1Q3D2_MYOLU | Homeobox domain-containing protein. (309 aa) |
| | LY6G5B | Lymphocyte antigen 6 family member G5B. (195 aa) |
| | UBA52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (127 aa) |
| | UBB | Uncharacterized protein. (114 aa) |
| | G1Q7H9_MYOLU | TAF domain-containing protein. (439 aa) |
| | G1Q7W4_MYOLU | Ubiquitin-like domain-containing protein. (128 aa) |
| | G1Q8T5_MYOLU | Uncharacterized protein. (80 aa) |
| | G1Q8Z6_MYOLU | TAFII28 domain-containing protein. (216 aa) |
| | G1Q980_MYOLU | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (283 aa) |
| | G1Q9J5_MYOLU | AMPK1_CBM domain-containing protein. (183 aa) |
| | LOC102442670 | Uncharacterized protein. (305 aa) |
| | LOC102437556 | TAFH domain-containing protein. (494 aa) |
| | G1QC31_MYOLU | Ubiquitin-like domain-containing protein. (155 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (243 aa) |
| | ENSMLUP00000021652 | annotation not available (162 aa) |
| | CDK5R2 | Cyclin-dependent kinase 5 activator. (369 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (586 aa) |
| | CDK3 | Cyclin dependent kinase 3. (241 aa) |
| | MEIOB | Meiosis specific with OB-fold. (473 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (265 aa) |
| | TAF11 | TATA-box binding protein associated factor 11. (208 aa) |
| | G1QDQ7_MYOLU | Ubiquitin-like domain-containing protein. (155 aa) |
| | G1QGB2_MYOLU | Ubiquitin-like domain-containing protein. (117 aa) |
| | G1QG66_MYOLU | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1083 aa) |
| | LOC102443195 | Uncharacterized protein. (124 aa) |
| | TAF5 | TATA-box binding protein associated factor 5. (615 aa) |
| | LOC102430695 | Ubiquitin-like domain-containing protein. (128 aa) |
| | CSNK2A2 | Casein kinase 2 alpha 2. (281 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1004 aa) |
| | TDRD3 | Tudor domain containing 3. (685 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (431 aa) |
| | TAF7 | TATA-box binding protein associated factor 7. (360 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (683 aa) |
| | L7N119_MYOLU | Uncharacterized protein. (790 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (714 aa) |
| | TBPL1 | TATA-box binding protein like 1. (186 aa) |
| | KXD1 | KxDL motif containing 1. (176 aa) |
| | TAF3 | TATA-box binding protein associated factor 3. (796 aa) |
| | DYRK4 | Dual specificity tyrosine phosphorylation regulated kinase 4. (565 aa) |
| | TAF15 | TATA-box binding protein associated factor 15. (518 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (339 aa) |
| | G1P107_MYOLU | Uncharacterized protein. (246 aa) |
| | PRKAG3 | Protein kinase AMP-activated non-catalytic subunit gamma 3. (496 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1852 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (320 aa) |
| | RFC2 | AAA domain-containing protein. (352 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | CCNA2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (427 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1523 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa) |
| | WRN | WRN RecQ like helicase. (1386 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (621 aa) |
