STRINGSTRING
PRKAR2B PRKAR2B PIK3CB PIK3CB SOCS1 SOCS1 FBP2 FBP2 INPP5A INPP5A G1NUS6_MYOLU G1NUS6_MYOLU EIF4E1B EIF4E1B PRKAR1A PRKAR1A RHOQ RHOQ G1NVZ4_MYOLU G1NVZ4_MYOLU ELK1 ELK1 CBLB CBLB AKT2 AKT2 ELK3 ELK3 SHC1 SHC1 SREBF2 SREBF2 CRK CRK PHKG1 PHKG1 GSK3B GSK3B PHKB PHKB SOCS3 SOCS3 PRKACB PRKACB SOS2 SOS2 RPS6KB1 RPS6KB1 PPP1CB PPP1CB INS INS PIK3R2 PIK3R2 G6PC G6PC PRKAG3 PRKAG3 TSC2 TSC2 RHEB RHEB PRKAG2 PRKAG2 G1P265_MYOLU G1P265_MYOLU G1P2N9_MYOLU G1P2N9_MYOLU PDPK1 PDPK1 SLC2A4 SLC2A4 EIF4E EIF4E CALML5 CALML5 PPP1CA PPP1CA PTPRS PTPRS RPS6KB2 RPS6KB2 PHKA1 PHKA1 CSDE1 CSDE1 PPP1R3F PPP1R3F GYS2 GYS2 FLOT1 FLOT1 MAPK9 MAPK9 KIAA1671 KIAA1671 G1P5Y1_MYOLU G1P5Y1_MYOLU MYO9A MYO9A G1P6G2_MYOLU G1P6G2_MYOLU PRKCI PRKCI CBL CBL G6PC3 G6PC3 ACACB ACACB SHC3 SHC3 TSC1 TSC1 BAD BAD SOCS4 SOCS4 SH2B2 SH2B2 CALM1 CALM1 EIF4EBP1 EIF4EBP1 BRAF BRAF RPS6 RPS6 G1P9Y9_MYOLU G1P9Y9_MYOLU MKNK1 MKNK1 SORBS3 SORBS3 PIK3CD PIK3CD PRKACA PRKACA RHEBL1 RHEBL1 MKNK2 MKNK2 G1PBZ4_MYOLU G1PBZ4_MYOLU RAPGEF1 RAPGEF1 GEM GEM RPTOR RPTOR TRIP10 TRIP10 HK2 HK2 PIK3CA PIK3CA PDE3B PDE3B GYS1 GYS1 PYGB PYGB PCK2 PCK2 IKBKB IKBKB CALML4 CALML4 PPP1R3A PPP1R3A ALKBH4 ALKBH4 CALM3 CALM3 IRS4 IRS4 BUD23 BUD23 PHKG2 PHKG2 SORBS1 SORBS1 PCK1 PCK1 PRKAG1 PRKAG1 EIF4E2 EIF4E2 MAPK3 MAPK3 MAP2K1 MAP2K1 GCK GCK HKDC1 HKDC1 HK1 HK1 SHC4 SHC4 PKLR PKLR FLOT2 FLOT2 RRAD RRAD INSR INSR FBP1 FBP1 INPPL1 INPPL1 AKT3 AKT3 PRKAA1 PRKAA1 PRKAA2 PRKAA2 SORBS2 SORBS2 MYO9B MYO9B PTPN1 PTPN1 G1PQ28_MYOLU G1PQ28_MYOLU MAPK8 MAPK8 ARAF ARAF PYGL PYGL ACACA ACACA MAPK10 MAPK10 HK3 HK3 CRKL CRKL PYGM PYGM GRB2 GRB2 PHKA2 PHKA2 PRKAB1 PRKAB1 PIK3R1 PIK3R1 SOCS2 SOCS2 SOS1 SOS1 KRAS KRAS EXOC7 EXOC7 SHC2 SHC2 PTPRF PTPRF PPP1R3B PPP1R3B PRKAR2A PRKAR2A PPARGC1A PPARGC1A LOC102419493 LOC102419493 G1PV07_MYOLU G1PV07_MYOLU TMEM145 TMEM145 LIPE LIPE RAF1 RAF1 ERAS ERAS PPP1R3C PPP1R3C LOC102430620 LOC102430620 PPP1CC PPP1CC LOC102428789 LOC102428789 G1Q3S8_MYOLU G1Q3S8_MYOLU G1Q4P8_MYOLU G1Q4P8_MYOLU G1Q5C7_MYOLU G1Q5C7_MYOLU G1Q5G9_MYOLU G1Q5G9_MYOLU LOC102436383 LOC102436383 CALM2 CALM2 IRS1 IRS1 G1Q7Q1_MYOLU G1Q7Q1_MYOLU LOC102437790 LOC102437790 PPP1R3G PPP1R3G G1Q9I3_MYOLU G1Q9I3_MYOLU G1Q9J5_MYOLU G1Q9J5_MYOLU G1Q9T3_MYOLU G1Q9T3_MYOLU G1QA52_MYOLU G1QA52_MYOLU G1QA68_MYOLU G1QA68_MYOLU G1QAL2_MYOLU G1QAL2_MYOLU BMT2 BMT2 G1QBB3_MYOLU G1QBB3_MYOLU ENSMLUP00000021192 ENSMLUP00000021192 NRAS NRAS REM1 REM1 EFCAB3 EFCAB3 LOC102440407 LOC102440407 PPP1R3E PPP1R3E G6PC2 G6PC2 G1QEB1_MYOLU G1QEB1_MYOLU G1QER2_MYOLU G1QER2_MYOLU G1QEZ1_MYOLU G1QEZ1_MYOLU PPP1R3D PPP1R3D
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (304 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
SOCS1Suppressor of cytokine signaling 1. (210 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (374 aa)
G1NUS6_MYOLUTubulin-specific chaperone A; Belongs to the TBCA family. (106 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (247 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (478 aa)
RHOQRas homolog family member Q. (168 aa)
G1NVZ4_MYOLUUncharacterized protein. (433 aa)
ELK1ETS transcription factor ELK1. (461 aa)
CBLBCbl proto-oncogene B. (983 aa)
AKT2Non-specific serine/threonine protein kinase. (467 aa)
ELK3ETS transcription factor ELK3. (402 aa)
SHC1SHC adaptor protein 1. (584 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1113 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PHKG1Phosphorylase kinase catalytic subunit gamma 1; Belongs to the protein kinase superfamily. (415 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (408 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1074 aa)
SOCS3Suppressor of cytokine signaling 3. (226 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1304 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (312 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
PIK3R2Uncharacterized protein. (730 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (496 aa)
TSC2TSC complex subunit 2. (1809 aa)
RHEBRas homolog, mTORC1 binding. (179 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (320 aa)
G1P265_MYOLUSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
G1P2N9_MYOLUUncharacterized protein. (1246 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (557 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
EIF4EUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (218 aa)
CALML5Calmodulin like 5. (149 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1338 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1243 aa)
CSDE1Cold shock domain containing E1. (813 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (626 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (419 aa)
MAPK9Mitogen-activated protein kinase. (423 aa)
KIAA1671KIAA1671. (1811 aa)
G1P5Y1_MYOLUMitogen-activated protein kinase. (321 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2626 aa)
G1P6G2_MYOLUUncharacterized protein. (438 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (671 aa)
CBLCbl proto-oncogene. (842 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
ACACBAcetyl-CoA carboxylase beta. (2453 aa)
SHC3SHC adaptor protein 3. (587 aa)
TSC1TSC complex subunit 1. (1167 aa)
BADBCL2 associated agonist of cell death. (174 aa)
SOCS4Suppressor of cytokine signaling 4. (441 aa)
SH2B2SH2B adaptor protein 2. (623 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (159 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (792 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
G1P9Y9_MYOLUFork-head domain-containing protein. (483 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (427 aa)
SORBS3Sorbin and SH3 domain containing 3. (742 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1053 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (243 aa)
RHEBL1RHEB like 1. (183 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (463 aa)
G1PBZ4_MYOLUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (373 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1217 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (293 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1012 aa)
TRIP10Thyroid hormone receptor interactor 10. (543 aa)
HK2Hexokinase 2. (917 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1070 aa)
PDE3BPhosphodiesterase. (813 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (472 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (868 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (662 aa)
IKBKBUncharacterized protein. (756 aa)
CALML4Calmodulin like 4. (196 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1111 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (298 aa)
CALM3Calmodulin 3; Belongs to the calmodulin family. (148 aa)
IRS4Insulin receptor substrate 4. (1031 aa)
BUD23BUD23 rRNA methyltransferase and ribosome maturation factor. (283 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
SORBS1Sorbin and SH3 domain containing 1. (1292 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (624 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
MAPK3Mitogen-activated protein kinase. (370 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
GCKPhosphotransferase. (438 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
HK1Hexokinase 1. (949 aa)
SHC4SHC adaptor protein 4. (629 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (588 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (455 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
INSRTyrosine-protein kinase receptor. (1336 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (281 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1265 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
PRKAA1Non-specific serine/threonine protein kinase. (517 aa)
PRKAA2Non-specific serine/threonine protein kinase. (528 aa)
SORBS2Sorbin and SH3 domain containing 2. (1222 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2127 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (403 aa)
G1PQ28_MYOLUAMPKBI domain-containing protein. (221 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (613 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (771 aa)
ACACAAcetyl-CoA carboxylase alpha. (2346 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
HK3Hexokinase 3. (924 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1236 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (715 aa)
SHC2PID domain-containing protein. (293 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1916 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (305 aa)
PPARGC1APPARG coactivator 1 alpha. (796 aa)
LOC102419493Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
G1PV07_MYOLUPKS_AT domain-containing protein. (181 aa)
TMEM145Transmembrane protein 145. (562 aa)
LIPELipase E, hormone sensitive type. (1051 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ERASES cell expressed Ras. (229 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
LOC102430620Uncharacterized protein. (226 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
LOC102428789Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (172 aa)
G1Q3S8_MYOLUUncharacterized protein. (520 aa)
G1Q4P8_MYOLUUncharacterized protein; Belongs to the calmodulin family. (145 aa)
G1Q5C7_MYOLUFlotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (375 aa)
G1Q5G9_MYOLU40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (235 aa)
LOC102436383SER_THR_PHOSPHATASE domain-containing protein. (321 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
IRS1Insulin receptor substrate 1. (1231 aa)
G1Q7Q1_MYOLUNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (443 aa)
LOC102437790Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (848 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (314 aa)
G1Q9I3_MYOLUIg-like domain-containing protein. (97 aa)
G1Q9J5_MYOLUAMPK1_CBM domain-containing protein. (183 aa)
G1Q9T3_MYOLUUncharacterized protein. (72 aa)
G1QA52_MYOLUUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (216 aa)
G1QA68_MYOLUUncharacterized protein. (64 aa)
G1QAL2_MYOLUFlotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (424 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (352 aa)
G1QBB3_MYOLUSH2 domain-containing protein. (270 aa)
ENSMLUP00000021192annotation not available (245 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
REM1RRAD and GEM like GTPase 1. (212 aa)
EFCAB3Uncharacterized protein. (438 aa)
LOC102440407Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (279 aa)
G6PC2Glucose-6-phosphatase catalytic subunit 2. (358 aa)
G1QEB1_MYOLUSH2 domain-containing protein. (266 aa)
G1QER2_MYOLUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (360 aa)
G1QEZ1_MYOLUProtein kinase C. (646 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (299 aa)
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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