95 items (Myotis lucifugus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102422871	NTR domain-containing protein. (882 aa)
	RAB1A	RAB1A, member RAS oncogene family. (205 aa)
	HSF5	Heat shock transcription factor 5. (634 aa)
	G1QEW2_MYOLU	Tr-type G domain-containing protein. (454 aa)
	G1QEM9_MYOLU	HSF_DOMAIN domain-containing protein. (241 aa)
	G1QDM9_MYOLU	HSF_DOMAIN domain-containing protein. (522 aa)
	LOC111825784	HSF_DOMAIN domain-containing protein. (340 aa)
	G1QD46_MYOLU	Protein kinase domain-containing protein. (567 aa)
	G1QCP9_MYOLU	Uncharacterized protein. (1667 aa)
	G1QBU7_MYOLU	C-X-C motif chemokine. (108 aa)
	SEC22B	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
	G1QBE5_MYOLU	Uncharacterized protein. (264 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (835 aa)
	ENSMLUP00000020832	annotation not available (105 aa)
	LOC102421025	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	G1Q9R1_MYOLU	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (390 aa)
	G1Q9C3_MYOLU	Anaphylatoxin-like domain-containing protein. (145 aa)
	G1Q987_MYOLU	Uncharacterized protein. (387 aa)
	G1Q976_MYOLU	NTR domain-containing protein. (771 aa)
	G1Q905_MYOLU	HSF_DOMAIN domain-containing protein. (341 aa)
	G1Q8Z5_MYOLU	MG1 domain-containing protein. (177 aa)
	EEF1G	Eukaryotic translation elongation factor 1 gamma. (438 aa)
	CLK1	CDC like kinase 1. (527 aa)
	METRNL	Meteorin like, glial cell differentiation regulator. (308 aa)
	HSPD1	Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (575 aa)
	BNIP3	BCL2 interacting protein 3. (204 aa)
	GUF1	Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (669 aa)
	HSF1	HSF_DOMAIN domain-containing protein. (525 aa)
	HSF2	Heat shock transcription factor 2. (514 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (277 aa)
	ITGB2	Integrin beta. (777 aa)
	CD14	CD14 molecule. (365 aa)
	CLK4	CDC like kinase 4; Belongs to the protein kinase superfamily. (481 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (269 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (238 aa)
	NFKBIA	ANK_REP_REGION domain-containing protein. (238 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	LOC102425512	Uncharacterized protein; Belongs to the heat shock protein 70 family. (681 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (972 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (765 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	SAR1A	Secretion associated Ras related GTPase 1A; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (827 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1252 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (545 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (416 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
	HBS1L	HBS1 like translational GTPase. (684 aa)
	HSF4	Heat shock transcription factor 4. (495 aa)
	LOC102442843	Uncharacterized protein. (1664 aa)
	LOC102441280	VWFA domain-containing protein. (583 aa)
	MYD88	MYD88 innate immune signal transduction adaptor. (189 aa)
	OTUD3	OTU deubiquitinase 3. (404 aa)
	CLK3	Protein kinase domain-containing protein. (624 aa)
	CLK2	CDC like kinase 2; Belongs to the protein kinase superfamily. (499 aa)
	EEF1A1	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (252 aa)
	BCL2L13	BCL2 like 13. (422 aa)
	LOC102434727	HSF_DOMAIN domain-containing protein. (223 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (481 aa)
	IL6	Interleukin 6. (208 aa)
	G1PTA0_MYOLU	HSF_DOMAIN domain-containing protein. (514 aa)
	SAR1B	Secretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	C7orf31	Chromosome 7 open reading frame 31. (590 aa)
	NLRC4	NLR family CARD domain containing 4. (1025 aa)
	EEF1A2	Eukaryotic translation elongation factor 1 alpha 2. (345 aa)
	G1PY32_MYOLU	Uncharacterized protein; Belongs to the heat shock protein 70 family. (516 aa)
	G1PYJ2_MYOLU	Uncharacterized protein. (1636 aa)
	G1PZ18_MYOLU	Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (267 aa)
	RAB1B	RAB1B, member RAS oncogene family. (203 aa)
	G1Q1G8_MYOLU	GTP_EFTU_D3 domain-containing protein. (303 aa)
	LOC102424734	HSF_DOMAIN domain-containing protein. (391 aa)
	LOC102425210	Uncharacterized protein; Belongs to the heat shock protein 70 family. (716 aa)
	G1Q265_MYOLU	NACHT domain-containing protein. (1443 aa)
	G1Q2N3_MYOLU	Uncharacterized protein. (318 aa)
	G1Q304_MYOLU	HSF_DOMAIN domain-containing protein. (316 aa)
	G1Q322_MYOLU	C-X-C motif chemokine. (157 aa)
	G1Q354_MYOLU	Uncharacterized protein. (369 aa)
	LOC102427544	C-X-C motif chemokine. (108 aa)
	LOC102419585	Anaphylatoxin-like domain-containing protein. (1162 aa)
	PYCARD	PYD and CARD domain containing. (197 aa)
	G1Q4W5_MYOLU	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (492 aa)
	LOC102420929	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
	LOC102419640	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
	G1Q6D5_MYOLU	GTP_EFTU_D3 domain-containing protein. (324 aa)
	LOC102439184	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (492 aa)
	G1Q6U3_MYOLU	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (455 aa)
	G1Q6X4_MYOLU	Uncharacterized protein. (84 aa)
	LOC102422416	NTR domain-containing protein. (920 aa)
	LOC111825782	HSF_DOMAIN domain-containing protein. (355 aa)
	G1Q855_MYOLU	Tr-type G domain-containing protein. (334 aa)
	TLR2	Toll-like receptor. (783 aa)

Your Current Organism:

Myotis lucifugus

NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	CASP3	ENSMLUP00000007636	ENSMLUP00000002223	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 3; Belongs to the peptidase C14A family.	0.992
APAF1	CASP7	ENSMLUP00000007636	ENSMLUP00000003478	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.963
APAF1	CASP8	ENSMLUP00000007636	ENSMLUP00000014156	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 8; Belongs to the peptidase C14A family.	0.973
APAF1	CASP9	ENSMLUP00000007636	ENSMLUP00000008827	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	EEF1G	ENSMLUP00000007636	ENSMLUP00000000312	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Eukaryotic translation elongation factor 1 gamma.	0.543
APAF1	ENSMLUP00000020832	ENSMLUP00000007636	ENSMLUP00000020832	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	annotation not available	0.996
APAF1	G1Q265_MYOLU	ENSMLUP00000007636	ENSMLUP00000017798	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	NACHT domain-containing protein.	0.841
APAF1	HBS1L	ENSMLUP00000007636	ENSMLUP00000009698	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	HBS1 like translational GTPase.	0.814
APAF1	HSPA1L	ENSMLUP00000007636	ENSMLUP00000019043	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family.	0.637
APAF1	LOC102419640	ENSMLUP00000007636	ENSMLUP00000018972	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.996
APAF1	LOC102420929	ENSMLUP00000007636	ENSMLUP00000018852	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.996
APAF1	LOC102421025	ENSMLUP00000007636	ENSMLUP00000020649	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.996
APAF1	LOC102425210	ENSMLUP00000007636	ENSMLUP00000017794	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.637
APAF1	LOC102425512	ENSMLUP00000007636	ENSMLUP00000004437	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.637
APAF1	NFKB1	ENSMLUP00000007636	ENSMLUP00000005478	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Nuclear factor kappa B subunit 1.	0.428
APAF1	TLR4	ENSMLUP00000007636	ENSMLUP00000006762	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.466
APAF1	TNF	ENSMLUP00000007636	ENSMLUP00000003613	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.519
BCL2L13	BNIP3	ENSMLUP00000013216	ENSMLUP00000001288	BCL2 like 13.	BCL2 interacting protein 3.	0.613
BNIP3	BCL2L13	ENSMLUP00000001288	ENSMLUP00000013216	BCL2 interacting protein 3.	BCL2 like 13.	0.613
BNIP3	CASP3	ENSMLUP00000001288	ENSMLUP00000002223	BCL2 interacting protein 3.	Caspase 3; Belongs to the peptidase C14A family.	0.643