STRINGSTRING
STAT3 STAT3 LOC102434797 LOC102434797 G1QER2_MYOLU G1QER2_MYOLU G1QEB1_MYOLU G1QEB1_MYOLU CLDN6 CLDN6 G1QD47_MYOLU G1QD47_MYOLU MYC MYC NRAS NRAS G1QBU5_MYOLU G1QBU5_MYOLU G1QBS6_MYOLU G1QBS6_MYOLU LOC102429393 LOC102429393 G1QBB3_MYOLU G1QBB3_MYOLU ENSMLUP00000020832 ENSMLUP00000020832 LOC102421025 LOC102421025 IKBKG IKBKG G1Q9T3_MYOLU G1Q9T3_MYOLU CDK4 CDK4 IFNB1 IFNB1 G1Q8T5_MYOLU G1Q8T5_MYOLU G1Q7N0_MYOLU G1Q7N0_MYOLU G1Q7M2_MYOLU G1Q7M2_MYOLU LOC102423271 LOC102423271 CLDN18 CLDN18 G1Q7A6_MYOLU G1Q7A6_MYOLU TICAM1 TICAM1 LOC102419640 LOC102419640 LOC102420929 LOC102420929 PPP2R2D PPP2R2D IRF3 IRF3 LOC102425662 LOC102425662 G1Q255_MYOLU G1Q255_MYOLU CLDN10 CLDN10 PPP2R2A PPP2R2A LOC102418172 LOC102418172 LOC102430620 LOC102430620 G1PZ51_MYOLU G1PZ51_MYOLU IFIT5 IFIT5 CFLAR CFLAR G1P5Y1_MYOLU G1P5Y1_MYOLU NFKB1 NFKB1 YWHAB YWHAB TP53 TP53 FASLG FASLG STAT2 STAT2 BAD BAD EIF3E EIF3E BRAF BRAF JAK1 JAK1 CLDN2 CLDN2 OCLN OCLN PIK3CD PIK3CD LOC102432100 LOC102432100 MAVS MAVS PANK2 PANK2 RB1 RB1 APAF1 APAF1 G1PBZ4_MYOLU G1PBZ4_MYOLU RELA RELA CTNNB1 CTNNB1 E2F2 E2F2 PIK3CA PIK3CA TRAF3 TRAF3 CASP9 CASP9 TBK1 TBK1 CLDN15 CLDN15 IKBKB IKBKB RNASEL RNASEL STAT1 STAT1 BAX BAX PIAS1 PIAS1 IFNAR2 IFNAR2 RXRA RXRA EIF2AK4 EIF2AK4 CDKN1A CDKN1A PPP2R1B PPP2R1B EIF2AK3 EIF2AK3 TRADD TRADD CCND1 CCND1 MAPK3 MAPK3 CLDN20 CLDN20 MX1 MX1 MAP2K1 MAP2K1 CDK6 CDK6 TYK2 TYK2 TLR3 TLR3 PPP2CB PPP2CB CLDN19 CLDN19 CLDN17 CLDN17 AKT3 AKT3 TNFRSF1A TNFRSF1A SCNN1A SCNN1A L7N1R0_MYOLU L7N1R0_MYOLU ARAF ARAF CLDN11 CLDN11 GRB2 GRB2 E2F1 E2F1 PIK3R1 PIK3R1 EGF EGF FAS FAS CASP8 CASP8 CLDN1 CLDN1 YWHAG YWHAG SOS1 SOS1 G1PT35_MYOLU G1PT35_MYOLU OAS3 OAS3 G1PT56_MYOLU G1PT56_MYOLU G1PTE9_MYOLU G1PTE9_MYOLU KRAS KRAS RIPK1 RIPK1 CHUK CHUK C7orf31 C7orf31 IFIT3 IFIT3 LOC102423703 LOC102423703 PPP2CA PPP2CA YWHAZ YWHAZ G1PWZ6_MYOLU G1PWZ6_MYOLU RAF1 RAF1 NR1H3 NR1H3 ERAS ERAS BID BID G1PYT2_MYOLU G1PYT2_MYOLU PIK3CB PIK3CB YWHAH YWHAH G1NVK3_MYOLU G1NVK3_MYOLU G1NVZ4_MYOLU G1NVZ4_MYOLU YWHAE YWHAE CLDN16 CLDN16 E2F3 E2F3 CLDN4 CLDN4 AKT2 AKT2 CASP3 CASP3 CLDN5 CLDN5 PPP2R1A PPP2R1A SCARB1 SCARB1 IFNG IFNG IKBKE IKBKE LOC102436559 LOC102436559 GSK3B GSK3B DDX58 DDX58 SOCS3 SOCS3 LOC102440260 LOC102440260 CLDN24 CLDN24 SOS2 SOS2 G1P0C3_MYOLU G1P0C3_MYOLU TRAF6 TRAF6 EIF2AK1 EIF2AK1 TNF TNF PIK3R2 PIK3R2 PSME3 PSME3 EIF2S1 EIF2S1 LDLR LDLR NFKBIA NFKBIA CLDN7 CLDN7 CDK2 CDK2 CXCL10 CXCL10 YWHAQ YWHAQ CSDE1 CSDE1 G1P5B5_MYOLU G1P5B5_MYOLU LOC102434482 LOC102434482 CLDN9 CLDN9 IFIT2 IFIT2 IRF9 IRF9 G1QFD3_MYOLU G1QFD3_MYOLU
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT3Signal transducer and activator of transcription. (773 aa)
LOC102434797Uncharacterized protein. (213 aa)
G1QER2_MYOLUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (360 aa)
G1QEB1_MYOLUSH2 domain-containing protein. (266 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
G1QD47_MYOLUUncharacterized protein; Belongs to the protein kinase superfamily. (448 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
G1QBU5_MYOLUUncharacterized protein. (541 aa)
G1QBS6_MYOLUUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (519 aa)
LOC102429393annotation not available (261 aa)
G1QBB3_MYOLUSH2 domain-containing protein. (270 aa)
ENSMLUP00000020832annotation not available (105 aa)
LOC102421025Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (425 aa)
G1Q9T3_MYOLUUncharacterized protein. (72 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
IFNB1Interferon beta 1. (186 aa)
G1Q8T5_MYOLUUncharacterized protein. (80 aa)
G1Q7N0_MYOLUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
G1Q7M2_MYOLUUncharacterized protein. (428 aa)
LOC102423271Uncharacterized protein. (235 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
G1Q7A6_MYOLUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (347 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (687 aa)
LOC102419640Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC102420929Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (453 aa)
IRF3Interferon regulatory factor 3. (421 aa)
LOC102425662Uncharacterized protein. (209 aa)
G1Q255_MYOLUUncharacterized protein. (460 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (419 aa)
LOC102418172Uncharacterized protein. (171 aa)
LOC102430620Uncharacterized protein. (226 aa)
G1PZ51_MYOLUCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
IFIT5Interferon induced protein with tetratricopeptide repeats 5. (481 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (487 aa)
G1P5Y1_MYOLUMitogen-activated protein kinase. (321 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (280 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
BADBCL2 associated agonist of cell death. (174 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (792 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (521 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1053 aa)
LOC102432100NR LBD domain-containing protein. (231 aa)
MAVSMitochondrial antiviral signaling protein. (525 aa)
PANK2Pantothenate kinase 2. (460 aa)
RB1RB transcriptional corepressor 1. (882 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1252 aa)
G1PBZ4_MYOLUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (373 aa)
RELARELA proto-oncogene, NF-kB subunit. (545 aa)
CTNNB1Catenin beta 1. (782 aa)
E2F2E2F transcription factor 2. (436 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1070 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
TBK1TANK binding kinase 1. (729 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
IKBKBUncharacterized protein. (756 aa)
RNASELRibonuclease L. (743 aa)
STAT1Signal transducer and activator of transcription. (1171 aa)
BAXBCL2 associated X, apoptosis regulator. (193 aa)
PIAS1Protein inhibitor of activated STAT 1. (651 aa)
IFNAR2Uncharacterized protein. (488 aa)
RXRARetinoid X receptor alpha. (460 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1597 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (192 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (546 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1015 aa)
TRADDTNFRSF1A associated via death domain. (310 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MAPK3Mitogen-activated protein kinase. (370 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
MX1MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (660 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TYK2Tyrosine-protein kinase. (1187 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
PPP2CBSerine/threonine-protein phosphatase. (276 aa)
CLDN19Claudin 19. (150 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
TNFRSF1ATNF receptor superfamily member 1A. (448 aa)
SCNN1ASodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (658 aa)
L7N1R0_MYOLUUncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (459 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (613 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
E2F1E2F transcription factor 1. (433 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1178 aa)
FASFas cell surface death receptor. (338 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (481 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
G1PT35_MYOLU25A_SYNTH_3 domain-containing protein. (345 aa)
OAS32'-5'-oligoadenylate synthetase 3. (1026 aa)
G1PT56_MYOLU25A_SYNTH_3 domain-containing protein. (334 aa)
G1PTE9_MYOLUSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (668 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (746 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
IFIT3Interferon induced protein with tetratricopeptide repeats 3. (471 aa)
LOC102423703Uncharacterized protein. (469 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (247 aa)
G1PWZ6_MYOLUUncharacterized protein. (465 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
ERASES cell expressed Ras. (229 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (191 aa)
G1PYT2_MYOLU25A_SYNTH_3 domain-containing protein. (389 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (217 aa)
G1NVK3_MYOLUUncharacterized protein. (190 aa)
G1NVZ4_MYOLUUncharacterized protein. (433 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (233 aa)
CLDN16Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (304 aa)
E2F3E2F transcription factor 3. (334 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
AKT2Non-specific serine/threonine protein kinase. (467 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (433 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (703 aa)
LOC102436559Uncharacterized protein. (248 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (408 aa)
DDX58DExD/H-box helicase 58. (928 aa)
SOCS3Suppressor of cytokine signaling 3. (226 aa)
LOC102440260Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
CLDN24Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1304 aa)
G1P0C3_MYOLUUncharacterized protein. (553 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (537 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (635 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (238 aa)
PIK3R2Uncharacterized protein. (730 aa)
PSME3Proteasome activator subunit 3. (254 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (316 aa)
LDLRLow density lipoprotein receptor. (856 aa)
NFKBIAANK_REP_REGION domain-containing protein. (238 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
CXCL10C-X-C motif chemokine. (98 aa)
YWHAQTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta; Belongs to the 14-3-3 family. (245 aa)
CSDE1Cold shock domain containing E1. (813 aa)
G1P5B5_MYOLUUncharacterized protein. (635 aa)
LOC102434482Uncharacterized protein. (213 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
IFIT2Interferon induced protein with tetratricopeptide repeats 2. (466 aa)
IRF9Interferon regulatory factor 9. (456 aa)
G1QFD3_MYOLUUncharacterized protein. (188 aa)
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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