STRINGSTRING
TGFA TGFA PIK3CB PIK3CB TGFB2 TGFB2 APPL1 APPL1 G1NVZ4_MYOLU G1NVZ4_MYOLU MSH3 MSH3 SMAD3 SMAD3 AKT2 AKT2 CASP3 CASP3 GSK3B GSK3B G1NZD6_MYOLU G1NZD6_MYOLU SOS2 SOS2 MLH1 MLH1 RPS6KB1 RPS6KB1 FOS FOS APC2 APC2 TCF7L1 TCF7L1 PIK3R2 PIK3R2 G1P265_MYOLU G1P265_MYOLU GADD45A GADD45A RPS6KB2 RPS6KB2 RALB RALB CSDE1 CSDE1 G1P5B5_MYOLU G1P5B5_MYOLU MAPK9 MAPK9 G1P5Y1_MYOLU G1P5Y1_MYOLU BIRC5 BIRC5 TP53 TP53 TCF7 TCF7 BAD BAD PMAIP1 PMAIP1 BRAF BRAF PIK3CD PIK3CD G1PBZ4_MYOLU G1PBZ4_MYOLU CTNNB1 CTNNB1 MSH6 MSH6 TCF7L2 TCF7L2 SMAD2 SMAD2 LEF1 LEF1 PIK3CA PIK3CA G1PDJ5_MYOLU G1PDJ5_MYOLU GADD45B GADD45B DCC DCC RALA RALA CASP9 CASP9 RAC1 RAC1 AXIN1 AXIN1 BAX BAX CDKN1A CDKN1A MSH2 MSH2 CCND1 CCND1 MAPK3 MAPK3 GADD45G GADD45G MAP2K1 MAP2K1 RAC2 RAC2 TGFB1 TGFB1 TGFB3 TGFB3 RHOA RHOA SMAD4 SMAD4 AKT3 AKT3 MAPK8 MAPK8 ARAF ARAF APC APC MAPK10 MAPK10 TGFBR1 TGFBR1 GRB2 GRB2 PIK3R1 PIK3R1 EREG EREG AREG AREG EGF EGF POLK POLK SOS1 SOS1 KRAS KRAS C7orf31 C7orf31 G1PWX7_MYOLU G1PWX7_MYOLU TGFBR2 TGFBR2 DDB2 DDB2 RAF1 RAF1 ERAS ERAS G1PZ51_MYOLU G1PZ51_MYOLU LOC102427260 LOC102427260 G1Q1Q1_MYOLU G1Q1Q1_MYOLU G1Q234_MYOLU G1Q234_MYOLU G1Q2Q4_MYOLU G1Q2Q4_MYOLU G1Q313_MYOLU G1Q313_MYOLU LOC102430746 LOC102430746 LOC102420929 LOC102420929 LOC102419640 LOC102419640 G1Q7Q1_MYOLU G1Q7Q1_MYOLU LOC102437790 LOC102437790 G1Q8T5_MYOLU G1Q8T5_MYOLU G1Q9T3_MYOLU G1Q9T3_MYOLU LOC102421025 LOC102421025 AXIN2 AXIN2 ENSMLUP00000020832 ENSMLUP00000020832 G1QBB3_MYOLU G1QBB3_MYOLU NRAS NRAS MYC MYC EPGN EPGN G1QDT5_MYOLU G1QDT5_MYOLU G1QEB1_MYOLU G1QEB1_MYOLU G1QER2_MYOLU G1QER2_MYOLU G1QEZ1_MYOLU G1QEZ1_MYOLU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFATransforming growth factor alpha. (128 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (708 aa)
G1NVZ4_MYOLUUncharacterized protein. (433 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1091 aa)
SMAD3Mothers against decapentaplegic homolog. (395 aa)
AKT2Non-specific serine/threonine protein kinase. (467 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (408 aa)
G1NZD6_MYOLURas-GEF domain-containing protein. (588 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1304 aa)
MLH1MutL homolog 1. (755 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
APC2APC regulator of WNT signaling pathway 2. (2288 aa)
TCF7L1Transcription factor 7 like 1. (458 aa)
PIK3R2Uncharacterized protein. (730 aa)
G1P265_MYOLUSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (487 aa)
RALBRAS like proto-oncogene B. (229 aa)
CSDE1Cold shock domain containing E1. (813 aa)
G1P5B5_MYOLUUncharacterized protein. (635 aa)
MAPK9Mitogen-activated protein kinase. (423 aa)
G1P5Y1_MYOLUMitogen-activated protein kinase. (321 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
TCF7Transcription factor 7. (339 aa)
BADBCL2 associated agonist of cell death. (174 aa)
PMAIP1Uncharacterized protein. (54 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (792 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1053 aa)
G1PBZ4_MYOLUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (373 aa)
CTNNB1Catenin beta 1. (782 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1357 aa)
TCF7L2Transcription factor 7 like 2. (437 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LEF1Lymphoid enhancer binding factor 1. (262 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1070 aa)
G1PDJ5_MYOLUBclx_interact domain-containing protein. (70 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
DCCUncharacterized protein. (1124 aa)
RALARAS like proto-oncogene A. (206 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
RAC1Rac family small GTPase 1. (211 aa)
AXIN1Axin 1. (866 aa)
BAXBCL2 associated X, apoptosis regulator. (193 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (192 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (939 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MAPK3Mitogen-activated protein kinase. (370 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
RAC2Rac family small GTPase 2. (192 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (449 aa)
RHOAUncharacterized protein. (193 aa)
SMAD4Mothers against decapentaplegic homolog. (554 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (613 aa)
APCAPC regulator of WNT signaling pathway. (2851 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (471 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EREGEpiregulin. (147 aa)
AREGAmphiregulin. (248 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1178 aa)
POLKDNA polymerase kappa. (866 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1304 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
G1PWX7_MYOLUUncharacterized protein. (871 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ERASES cell expressed Ras. (229 aa)
G1PZ51_MYOLUCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
LOC102427260Uncharacterized protein. (143 aa)
G1Q1Q1_MYOLURas-GEF domain-containing protein. (584 aa)
G1Q234_MYOLUBZIP domain-containing protein; Belongs to the bZIP family. (204 aa)
G1Q2Q4_MYOLUUncharacterized protein. (194 aa)
G1Q313_MYOLUUncharacterized protein. (191 aa)
LOC102430746Uncharacterized protein. (193 aa)
LOC102420929Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
LOC102419640Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
G1Q7Q1_MYOLUNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (443 aa)
LOC102437790Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (848 aa)
G1Q8T5_MYOLUUncharacterized protein. (80 aa)
G1Q9T3_MYOLUUncharacterized protein. (72 aa)
LOC102421025Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
AXIN2Axin 2. (564 aa)
ENSMLUP00000020832annotation not available (105 aa)
G1QBB3_MYOLUSH2 domain-containing protein. (270 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
EPGNEpithelial mitogen. (153 aa)
G1QDT5_MYOLURas-GEF domain-containing protein. (527 aa)
G1QEB1_MYOLUSH2 domain-containing protein. (266 aa)
G1QER2_MYOLUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (360 aa)
G1QEZ1_MYOLUProtein kinase C. (646 aa)
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
Server load: low (16%) [HD]