STRINGSTRING
ITGA2 ITGA2 MAX MAX LAMA1 LAMA1 PIK3R2 PIK3R2 TRAF6 TRAF6 CDKN1B CDKN1B SKP2 SKP2 PTEN PTEN CASP3 CASP3 CKS1B CKS1B AKT2 AKT2 E2F3 E2F3 FN1 FN1 XIAP XIAP RARB RARB G1NVZ4_MYOLU G1NVZ4_MYOLU LAMA2 LAMA2 G1NUL5_MYOLU G1NUL5_MYOLU G1NU61_MYOLU G1NU61_MYOLU LAMA5 LAMA5 PIK3CB PIK3CB RXRG RXRG ENSMLUP00000022385 ENSMLUP00000022385 ZBTB17 ZBTB17 G1QEB1_MYOLU G1QEB1_MYOLU MYC MYC G1QBB3_MYOLU G1QBB3_MYOLU ENSMLUP00000020832 ENSMLUP00000020832 LOC102421025 LOC102421025 G1QA99_MYOLU G1QA99_MYOLU IKBKG IKBKG CDK4 CDK4 G1Q8T5_MYOLU G1Q8T5_MYOLU G1Q7N0_MYOLU G1Q7N0_MYOLU LOC102421956 LOC102421956 LOC102419640 LOC102419640 LOC102420929 LOC102420929 LOC102417379 LOC102417379 G1Q4C4_MYOLU G1Q4C4_MYOLU TRAF5 TRAF5 G1Q1H5_MYOLU G1Q1H5_MYOLU LOC102433247 LOC102433247 LOC102430620 LOC102430620 G1PZ51_MYOLU G1PZ51_MYOLU DDB2 DDB2 COL4A2 COL4A2 COL4A1 COL4A1 ITGB1 ITGB1 G1PX21_MYOLU G1PX21_MYOLU LAMB4 LAMB4 LAMB1 LAMB1 C7orf31 C7orf31 CHUK CHUK G1PTC9_MYOLU G1PTC9_MYOLU BIRC2 BIRC2 BIRC3 BIRC3 POLK POLK PIK3R1 PIK3R1 E2F1 E2F1 LAMA3 LAMA3 COL4A5 COL4A5 COL4A6 COL4A6 AKT3 AKT3 RXRB RXRB G1PP20_MYOLU G1PP20_MYOLU TRAF4 TRAF4 CCNE2 CCNE2 SECISBP2 SECISBP2 CDK6 CDK6 GADD45G GADD45G CCND1 CCND1 PTK2 PTK2 CDKN1A CDKN1A RXRA RXRA MFF MFF BAX BAX IKBKB IKBKB CASP9 CASP9 TRAF3 TRAF3 GADD45B GADD45B COL4A3 COL4A3 PIK3CA PIK3CA E2F2 E2F2 RELA RELA APAF1 APAF1 RB1 RB1 PTGS2 PTGS2 PIK3CD PIK3CD ITGAV ITGAV BCL2L1 BCL2L1 LAMC2 LAMC2 LAMB3 LAMB3 LAMC1 LAMC1 TP53 TP53 CCNE1 CCNE1 NFKB1 NFKB1 ITGA6 ITGA6 ITGA3 ITGA3 TRAF1 TRAF1 CDK2 CDK2 GADD45A GADD45A NFKBIA NFKBIA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1192 aa)
MAXMYC associated factor X. (160 aa)
LAMA1Laminin subunit alpha 1. (3057 aa)
PIK3R2Uncharacterized protein. (730 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (537 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
SKP2S-phase kinase associated protein 2. (427 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (352 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (277 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (94 aa)
AKT2Non-specific serine/threonine protein kinase. (467 aa)
E2F3E2F transcription factor 3. (334 aa)
FN1Fibronectin 1. (2474 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
RARBRetinoic acid receptor beta. (448 aa)
G1NVZ4_MYOLUUncharacterized protein. (433 aa)
LAMA2Laminin subunit alpha 2. (3088 aa)
G1NUL5_MYOLUCollagen IV NC1 domain-containing protein. (1690 aa)
G1NU61_MYOLUUncharacterized protein. (1819 aa)
LAMA5Laminin subunit alpha 5. (3592 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RXRGRetinoid X receptor gamma. (258 aa)
ENSMLUP00000022385annotation not available (208 aa)
ZBTB17Zinc finger and BTB domain containing 17. (792 aa)
G1QEB1_MYOLUSH2 domain-containing protein. (266 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
G1QBB3_MYOLUSH2 domain-containing protein. (270 aa)
ENSMLUP00000020832annotation not available (105 aa)
LOC102421025Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
G1QA99_MYOLUUncharacterized protein. (49 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (425 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (303 aa)
G1Q8T5_MYOLUUncharacterized protein. (80 aa)
G1Q7N0_MYOLUProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
LOC102421956Bis(5'-adenosyl)-triphosphatase. (149 aa)
LOC102419640Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC102420929Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (102 aa)
LOC102417379Uncharacterized protein. (549 aa)
G1Q4C4_MYOLUNAD_binding_1 domain-containing protein. (104 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (569 aa)
G1Q1H5_MYOLUUncharacterized protein. (450 aa)
LOC102433247Uncharacterized protein. (1065 aa)
LOC102430620Uncharacterized protein. (226 aa)
G1PZ51_MYOLUCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
COL4A2Collagen type IV alpha 2 chain. (1647 aa)
COL4A1Collagen type IV alpha 1 chain. (1623 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
G1PX21_MYOLUIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (621 aa)
LAMB4Laminin subunit beta 4. (1750 aa)
LAMB1Laminin subunit beta 1. (1667 aa)
C7orf31Chromosome 7 open reading frame 31. (590 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (746 aa)
G1PTC9_MYOLUNitric oxide synthase; Produces nitric oxide (NO). (1274 aa)
BIRC2Baculoviral IAP repeat containing 2. (621 aa)
BIRC3Baculoviral IAP repeat containing 3. (603 aa)
POLKDNA polymerase kappa. (866 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
E2F1E2F transcription factor 1. (433 aa)
LAMA3Laminin subunit alpha 3. (3240 aa)
COL4A5Collagen IV NC1 domain-containing protein. (1662 aa)
COL4A6Collagen type IV alpha 6 chain. (1643 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (462 aa)
RXRBRetinoid X receptor beta. (532 aa)
G1PP20_MYOLUHIT domain-containing protein. (104 aa)
TRAF4TNF receptor-associated factor. (423 aa)
CCNE2Cyclin E2; Belongs to the cyclin family. (405 aa)
SECISBP2SECIS binding protein 2. (846 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1074 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (192 aa)
RXRARetinoid X receptor alpha. (460 aa)
MFFMitochondrial fission factor. (342 aa)
BAXBCL2 associated X, apoptosis regulator. (193 aa)
IKBKBUncharacterized protein. (756 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (416 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
COL4A3Collagen type IV alpha 3 chain. (1676 aa)
PIK3CAPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; Belongs to the PI3/PI4-kinase family. (1070 aa)
E2F2E2F transcription factor 2. (436 aa)
RELARELA proto-oncogene, NF-kB subunit. (545 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1252 aa)
RB1RB transcriptional corepressor 1. (882 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1053 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (996 aa)
BCL2L1BCL2 like 1. (233 aa)
LAMC2Laminin subunit gamma 2. (1168 aa)
LAMB3Laminin subunit beta 3. (1180 aa)
LAMC1Laminin subunit gamma 1. (1570 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (392 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (373 aa)
NFKB1Nuclear factor kappa B subunit 1. (972 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1130 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1066 aa)
TRAF1TNF receptor-associated factor. (415 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
NFKBIAANK_REP_REGION domain-containing protein. (238 aa)
Your Current Organism:
Myotis lucifugus
NCBI taxonomy Id: 59463
Other names: M. lucifugus, little brown bat
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