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| | nadE | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (281 aa) |
| | ADU40132.1 | KEGG: vap:Vapar_5264 hypothetical protein. (450 aa) |
| | ADU40071.1 | KEGG: mei:Msip34_2301 hypothetical protein. (143 aa) |
| | ADU40062.1 | KEGG: vap:Vapar_5187 adenylate/guanylate cyclase with CHASE sensor; PFAM: CHASE2 domain protein; adenylyl cyclase class-3/4/guanylyl cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase. (750 aa) |
| | ADU40061.1 | KEGG: vap:Vapar_5186 beta-lactamase domain protein. (286 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (162 aa) |
| | ADU40040.1 | KEGG: vap:Vapar_5167 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: Adenylosuccinate lyase domain-containing protein; fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (459 aa) |
| | ADU40017.1 | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa) |
| | ADU39976.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: vap:Vapar_5103 glyoxalase/bleomycin resistance protein/dioxygenase. (182 aa) |
| | pgk | KEGG: vap:Vapar_5101 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (397 aa) |
| | ADU39973.1 | TIGRFAM: pyruvate kinase; KEGG: vap:Vapar_5100 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (482 aa) |
| | ADU39969.1 | Fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: vap:Vapar_5096 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase. (301 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (183 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (397 aa) |
| | pyrF | TIGRFAM: orotidine 5'-phosphate decarboxylase; KEGG: vap:Vapar_5082 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (282 aa) |
| | ADU39925.1 | Hypothetical protein; Manually curated; KEGG: vap:Vapar_5061 hypothetical protein. (370 aa) |
| | ADU39904.1 | PFAM: AMP-dependent synthetase and ligase; KEGG: vap:Vapar_5042 AMP-dependent synthetase and ligase. (540 aa) |
| | ADU39834.1 | KEGG: sml:Smlt0260 putative nicotinate phosphoribosyltransferase; PFAM: Nicotinate phosphoribosyltransferase-like; Belongs to the NAPRTase family. (485 aa) |
| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (505 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (269 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (399 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (292 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (89 aa) |
| | atpF | ATP synthase F0, B subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (176 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (537 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (291 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (466 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa) |
| | ADU39633.1 | KEGG: vap:Vapar_4817 phosphoheptose isomerase. (214 aa) |
| | ADU39624.1 | KEGG: vap:Vapar_4807 putative fructose transport system kinase. (214 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (291 aa) |
| | ADU39584.1 | KEGG: vap:Vapar_4772 phospholipase D/transphosphatidylase; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase. (599 aa) |
| | ADU39575.1 | PFAM: CBS domain containing protein; transporter-associated region; KEGG: vap:Vapar_4763 CBS domain containing protein. (292 aa) |
| | ADU39552.1 | KEGG: vap:Vapar_4747 phosphoesterase PA-phosphatase related; PFAM: phosphoesterase PA-phosphatase related; SMART: phosphoesterase PA-phosphatase related. (277 aa) |
| | ADU39550.1 | KEGG: vap:Vapar_4745 diacylglycerol kinase catalytic region; PFAM: diacylglycerol kinase catalytic region; SMART: diacylglycerol kinase catalytic region. (322 aa) |
| | ADU39545.1 | KEGG: vap:Vapar_4741 phospholipid/glycerol acyltransferase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase. (244 aa) |
| | ADU39526.1 | PFAM: metallophosphoesterase; KEGG: hch:HCH_01549 phosphohydrolase. (279 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (628 aa) |
| | ADU39472.1 | KEGG: nar:Saro_3550 hypothetical protein. (141 aa) |
| | ADU39445.1 | KEGG: vap:Vapar_4662 phospholipid/glycerol acyltransferase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase. (241 aa) |
| | ADU39441.1 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: vap:Vapar_4658 CDP-alcohol phosphatidyltransferase. (204 aa) |
| | ADU39435.1 | PFAM: metallophosphoesterase; KEGG: vap:Vapar_4655 metallophosphoesterase. (289 aa) |
| | purH | SMART: AICARFT/IMPCHase bienzyme formylation region; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; KEGG: vap:Vapar_4630 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme formylation region; MGS domain protein. (535 aa) |
| | ADU39385.1 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: vap:Vapar_4628 phosphomethylpyrimidine kinase type-1. (320 aa) |
| | ADU39377.1 | KEGG: vap:Vapar_4617 protein of unknown function DUF179; manually curated; PFAM: protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family. (199 aa) |
| | pyrB | KEGG: vap:Vapar_4614 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (320 aa) |
| | ADU39373.1 | Dihydroorotase; KEGG: vap:Vapar_4613 dihydroorotase. (427 aa) |
| | ADU39372.1 | KEGG: vap:Vapar_4612 phospholipid/glycerol acyltransferase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase. (248 aa) |
| | ADU39359.1 | KEGG: vap:Vapar_4490 transport-associated; PFAM: transport-associated; SMART: Transport-associated and nodulation region. (278 aa) |
| | ADU39350.1 | PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: vap:Vapar_4480 5-carboxymethyl-2-hydroxymuconate delta-isomerase. (258 aa) |
| | ADU39347.1 | TIGRFAM: pyruvate kinase; KEGG: vap:Vapar_4478 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (473 aa) |
| | fdhD-3 | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (296 aa) |
| | ADU39274.1 | KEGG: gau:GAU_3343 hypothetical protein. (123 aa) |
| | ADU39255.1 | Manually curated; PFAM: ferredoxin; adenylyl cyclase class-3/4/guanylyl cyclase; KEGG: vap:Vapar_4418 adenylate/guanylate cyclase; SMART: adenylyl cyclase class-3/4/guanylyl cyclase. (556 aa) |
| | ADU39233.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: vap:Vapar_4412 glyoxalase/bleomycin resistance protein/dioxygenase. (139 aa) |
| | ADU39232.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: vap:Vapar_4410 glyoxalase/bleomycin resistance protein/dioxygenase. (145 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (167 aa) |
| | ADU39174.1 | PFAM: Phosphoglycerate mutase; KEGG: vap:Vapar_4362 phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (231 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (293 aa) |
| | nadK | ATP-NAD/AcoX kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (303 aa) |
| | ADU39133.1 | TIGRFAM: type III secretion apparatus H+-transporting two-sector ATPase; ATPase, FliI/YscN family; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain protein; KEGG: cti:RALTA_B1253 SctN: non flagellar T3S system conserved protein. ATPase alpha/beta chains family; SMART: AAA ATPase. (457 aa) |
| | ADU39123.1 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (752 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | ADU39116.1 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (199 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (202 aa) |
| | ADU38948.1 | KEGG: vap:Vapar_4119 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase. (243 aa) |
| | ADU38933.1 | PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: vap:Vapar_4105 UBA/ThiF-type NAD/FAD binding protein. (255 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa) |
| | gpsA | PFAM: NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; KEGG: vap:Vapar_4099 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (344 aa) |
| | ADU38926.1 | TIGRFAM: nicotinate-nucleotide pyrophosphorylase; KEGG: vap:Vapar_4098 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family. (292 aa) |
| | ADU38925.1 | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (376 aa) |
| | ADU38920.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (523 aa) |
| | ADU38896.1 | KEGG: aav:Aave_3827 oxidoreductase alpha (molybdopterin) subunit; TIGRFAM: oxidoreductase alpha (molybdopterin) subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (784 aa) |
| | ADU38895.1 | KEGG: dac:Daci_4812 hypothetical protein. (95 aa) |
| | fdhD-2 | Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (305 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (322 aa) |
| | ADU38815.1 | PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: vap:Vapar_4014 hypothetical protein. (109 aa) |
| | ADU38668.1 | Citryl-CoA lyase; KEGG: vap:Vapar_3898 citrate (pro-3S)-lyase; PFAM: HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family. (289 aa) |
| | ADU38662.1 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (353 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa) |
| | purA-2 | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (449 aa) |
| | ADU38624.1 | KEGG: vap:Vapar_0467 phospholipase D/transphosphatidylase; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase. (560 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa) |
| | ADU38564.1 | KEGG: vap:Vapar_4437 hypothetical protein. (485 aa) |
| | ADU38557.1 | KEGG: ctt:CtCNB1_4022 metal dependent phosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region. (193 aa) |
| | ADU38555.1 | KEGG: vap:Vapar_3808 phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase. (328 aa) |
| | plsY | Protein of unknown function DUF205; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (211 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa) |
| | ADU38504.1 | KEGG: vap:Vapar_3482 5'-nucleotidase domain protein; manually curated; PFAM: 5'-Nucleotidase domain-containing protein; metallophosphoesterase; Belongs to the 5'-nucleotidase family. (605 aa) |
| | ADU38491.1 | KEGG: vap:Vapar_3738 hypothetical protein. (280 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (217 aa) |
| | ADU38457.1 | KEGG: vap:Vapar_3712 hypothetical protein. (191 aa) |
| | ADU38277.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: nfa:nfa43940 hypothetical protein. (136 aa) |
| | ADU38273.1 | PFAM: inositol monophosphatase; KEGG: vap:Vapar_3566 inositol monophosphatase. (349 aa) |
| | ADU38247.1 | KEGG: vap:Vapar_3554 molybdenum cofactor synthesis domain protein; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: molybdopterin binding domain. (198 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (262 aa) |
| | ADU38182.1 | PFAM: NUDIX hydrolase; KEGG: vap:Vapar_3495 NUDIX hydrolase. (201 aa) |
| | ADU38058.1 | Manually curated; PFAM: phospholipase D/Transphosphatidylase; KEGG: vap:Vapar_2014 phospholipase D/transphosphatidylase; SMART: phospholipase D/Transphosphatidylase. (544 aa) |
| | ADU38041.1 | PFAM: HpcH/HpaI aldolase; KEGG: vap:Vapar_2028 HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family. (288 aa) |
| | ADU38039.1 | PFAM: CinA domain protein; KEGG: vap:Vapar_2030 CinA domain protein; Belongs to the CinA family. (162 aa) |
| | ADU38018.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: vap:Vapar_4147 glyoxalase/bleomycin resistance protein/dioxygenase. (144 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (358 aa) |
| | rpiA | Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (237 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa) |
| | ADU37914.1 | 2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (909 aa) |
| | ADU37913.1 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (559 aa) |
| | ADU37904.1 | propionate/CoA ligase; KEGG: vap:Vapar_2170 propionyl-CoA synthetase; TIGRFAM: propionate/CoA ligase; PFAM: AMP-dependent synthetase and ligase. (637 aa) |
| | ADU37903.1 | TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; KEGG: vap:Vapar_2171 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component. (958 aa) |
| | ADU37902.1 | 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (421 aa) |
| | ADU37901.1 | KEGG: vap:Vapar_2173 dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region. (475 aa) |
| | ndk | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (425 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (443 aa) |
| | ADU37875.1 | PFAM: phosphoribosyltransferase; KEGG: vap:Vapar_2199 phosphoribosyltransferase. (174 aa) |
| | ADU37874.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: vap:Vapar_2201 glyoxalase/bleomycin resistance protein/dioxygenase. (154 aa) |
| | ADU37831.1 | PFAM: thioesterase superfamily protein; KEGG: dac:Daci_5863 thioesterase superfamily protein. (131 aa) |
| | ADU37808.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (642 aa) |
| | ADU37807.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (417 aa) |
| | ADU37802.1 | Nitrate reductase; KEGG: vap:Vapar_4062 molybdopterin oxidoreductase; PFAM: molybdopterin oxidoreductase; molybdopterin oxidoreductase Fe4S4 region; molydopterin dinucleotide-binding region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (995 aa) |
| | ADU37797.1 | KEGG: vap:Vapar_4067 hypothetical protein. (196 aa) |
| | fdhD | Formate dehydrogenase subunit FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (303 aa) |
| | nadX | Aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. (265 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (258 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (326 aa) |
| | ADU37539.1 | PFAM: Phosphoglycerate mutase; KEGG: vap:Vapar_2568 phosphoglycerate mutase. (187 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (237 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (164 aa) |
| | ADU37521.1 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (746 aa) |
| | nnrE | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (486 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa) |
| | ADU37507.1 | PFAM: phosphatidate cytidylyltransferase; KEGG: vap:Vapar_2604 phosphatidate cytidylyltransferase; Belongs to the CDS family. (281 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (395 aa) |
| | lpxD | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (325 aa) |
| | fabZ | Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (149 aa) |
| | lpxA | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (262 aa) |
| | lpxB | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (382 aa) |
| | carA | KEGG: vap:Vapar_2615 carbamoyl phosphate synthase small subunit; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; Belongs to the CarA family. (402 aa) |
| | carB | KEGG: vap:Vapar_2617 carbamoyl-phosphate synthase, large subunit; TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; MGS domain protein; Belongs to the CarB family. (1082 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (341 aa) |
| | ADU37448.1 | Phospholipase D/Transphosphatidylase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (481 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1335 aa) |
| | ADU37347.1 | PFAM: aminotransferase class V; KEGG: vap:Vapar_2906 aminotransferase class V. (414 aa) |
| | ADU37317.1 | KEGG: scl:sce6063 hypothetical protein. (170 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (218 aa) |
| | ADU37259.1 | PFAM: CinA domain protein; KEGG: azo:azo1824 CinA domain-containing protein; Belongs to the CinA family. (171 aa) |
| | ADU37240.1 | PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase GAPDH domain protein; KEGG: cag:Cagg_1794 myo-inositol-1-phosphate synthase. (384 aa) |
| | ADU37235.1 | KEGG: mno:Mnod_0134 hypothetical protein. (587 aa) |
| | ADU37180.1 | KEGG: aav:Aave_2290 phospholipase D/transphosphatidylase; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase. (426 aa) |
| | ADU37139.1 | KEGG: vap:Vapar_2799 putative adenylate/guanylate cyclase; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; Forkhead-associated protein; SMART: Forkhead-associated protein. (315 aa) |
| | ADU37108.1 | KEGG: vap:Vapar_0209 hypothetical protein. (133 aa) |
| | guaA | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. (538 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa) |
| | ADU36912.1 | Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (200 aa) |
| | nadD | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (210 aa) |
| | purD | TIGRFAM: phosphoribosylamine/glycine ligase; KEGG: vap:Vapar_2684 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthetase, C-domain; Belongs to the GARS family. (432 aa) |
| | ADU36902.1 | KEGG: vap:Vapar_2680 phospholipid/glycerol acyltransferase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase. (265 aa) |
| | ADU36901.1 | PFAM: glycosyl transferase family 2; KEGG: vap:Vapar_2679 glycosyl transferase family 2. (258 aa) |
| | ADU36851.1 | L-ribulokinase; KEGG: sli:Slin_1239 L-ribulokinase; TIGRFAM: L-ribulokinase; PFAM: Carbohydrate kinase, FGGY-like; Belongs to the ribulokinase family. (552 aa) |
| | ADU34231.1 | PFAM: metallophosphoesterase; KEGG: vap:Vapar_0008 metallophosphoesterase. (402 aa) |
| | ADU34233.1 | PFAM: Lipid A 3-O-deacylase-related; KEGG: vap:Vapar_0010 hypothetical protein. (191 aa) |
| | clsB | Phospholipase D/Transphosphatidylase; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (423 aa) |
| | ADU34264.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: psa:PST_3589 glyoxylase I family protein. (249 aa) |
| | ADU34324.1 | KEGG: vap:Vapar_0089 benzoate-CoA ligase family; TIGRFAM: benzoate-CoA ligase family; PFAM: AMP-dependent synthetase and ligase. (515 aa) |
| | ADU34344.1 | KEGG: vap:Vapar_0107 acetoacetyl-CoA synthetase; TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase. (667 aa) |
| | ADU34346.1 | KEGG: vap:Vapar_0108 adenylate/guanylate cyclase with integral membrane sensor; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; histidine kinase HAMP region domain protein; Cache domain protein; SMART: adenylyl cyclase class-3/4/guanylyl cyclase. (655 aa) |
| | ADU34377.1 | KEGG: vap:Vapar_0142 phospholipase D/transphosphatidylase; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase. (525 aa) |
| | ADU34429.1 | KEGG: vap:Vapar_0178 6-hydroxynicotinate reductase. (541 aa) |
| | ADU34437.1 | Nicotinamidase; KEGG: vap:Vapar_0187 nicotinamidase; PFAM: isochorismatase hydrolase. (241 aa) |
| | ADU34471.1 | KEGG: vap:Vapar_0244 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase,HpaG2 subunit; TIGRFAM: 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase,HpaG2 subunit; PFAM: fumarylacetoacetate (FAA) hydrolase. (256 aa) |
| | ADU34472.1 | PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: vap:Vapar_0245 fumarylacetoacetate (FAA) hydrolase. (211 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (227 aa) |
| | ADU34588.1 | PFAM: thioesterase superfamily protein; KEGG: vap:Vapar_0351 thioesterase superfamily protein. (149 aa) |
| | ADU34590.1 | KEGG: vap:Vapar_0353 gentisate 1,2-dioxygenase; TIGRFAM: gentisate 1,2-dioxygenase; PFAM: Cupin 2 conserved barrel domain protein. (365 aa) |
| | ADU34597.1 | KEGG: vap:Vapar_0359 choloyl-CoA hydrolase; PFAM: acyl-CoA thioesterase. (292 aa) |
| | ADU34608.1 | KEGG: vap:Vapar_0367 ATP synthase F0, C subunit; TIGRFAM: ATP synthase F0, C subunit; PFAM: H+transporting two-sector ATPase C subunit. (79 aa) |
| | ADU34610.1 | PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: vap:Vapar_0369 deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase. (286 aa) |
| | ADU34616.1 | Glycerol-3-phosphate dehydrogenase; KEGG: vap:Vapar_0375 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase. (586 aa) |
| | pfp | Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (426 aa) |
| | ADU34707.1 | KEGG: vap:Vapar_0467 phospholipase D/transphosphatidylase; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase. (533 aa) |
| | ADU34737.1 | PFAM: CinA domain protein; KEGG: vap:Vapar_0483 CinA domain protein; Belongs to the CinA family. (175 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (319 aa) |
| | ADU34749.1 | TIGRFAM: ribulose-phosphate 3-epimerase; KEGG: vap:Vapar_0494 ribulose-phosphate 3-epimerase; PFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (230 aa) |
| | ADU34758.1 | KEGG: bac:BamMC406_6428 phospholipase D/transphosphatidylase. (683 aa) |
| | ADU34815.1 | PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: vap:Vapar_0558 AIR synthase related protein. (337 aa) |
| | ADU35031.1 | Ureidoglycolate lyase; KEGG: vap:Vapar_0790 5-carboxymethyl-2-hydroxymuconate delta-isomerase; PFAM: fumarylacetoacetate (FAA) hydrolase. (282 aa) |
| | ADU35045.1 | PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: vap:Vapar_0805 fumarate reductase/succinate dehydrogenase flavoprotein domain protein. (471 aa) |
| | ADU35059.1 | KEGG: vap:Vapar_0816 hypothetical protein. (278 aa) |
| | ADU35064.1 | KEGG: vap:Vapar_0822 thioesterase superfamily protein; manually curated; PFAM: thioesterase superfamily protein. (141 aa) |
| | pyrC | Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (343 aa) |
| | ADU35162.1 | 5'-nucleotidase; Manually curated; KEGG: tel:tlr1272 5'-nucleotidase; PFAM: 5-nucleotidase. (325 aa) |
| | lpxC | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (329 aa) |
| | ADU35207.1 | KEGG: vap:Vapar_0932 phospholipid/glycerol acyltransferase; PFAM: phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase. (283 aa) |
| | ADU35225.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | ADU35230.1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (411 aa) |
| | ADU35250.1 | PFAM: Phosphoglycerate mutase; KEGG: vap:Vapar_0972 phosphoglycerate mutase. (214 aa) |
| | ADU35262.1 | KEGG: vap:Vapar_0980 histidinol-phosphate phosphatase; TIGRFAM: histidinol-phosphate phosphatase; PFAM: inositol monophosphatase. (258 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (478 aa) |
| | ADU35303.1 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. (359 aa) |
| | ADU35370.1 | 5'-nucleotidase; KEGG: vap:Vapar_1070 5'-nucleotidase; PFAM: 5-nucleotidase. (299 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (489 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (318 aa) |
| | pgi | KEGG: vap:Vapar_1103 glucose-6-phosphate isomerase; PFAM: phosphoglucose isomerase (PGI); Belongs to the GPI family. (519 aa) |
| | ADU35406.1 | KEGG: vap:Vapar_1105 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; Belongs to the PdxA family. (354 aa) |
| | ADU35415.1 | PFAM: Transaldolase; KEGG: vap:Vapar_1114 transaldolase. (223 aa) |
| | ADU35423.1 | KEGG: vap:Vapar_1121 phospholipase D/transphosphatidylase; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase. (529 aa) |
| | ADU35449.1 | TIGRFAM: deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase HD sub domain; KEGG: vap:Vapar_1147 deoxyguanosinetriphosphate triphosphohydrolase-like protein; SMART: metal-dependent phosphohydrolase HD region; Belongs to the dGTPase family. Type 2 subfamily. (376 aa) |
| | ADU35490.1 | TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; KEGG: vap:Vapar_1186 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; Belongs to the PdxA family. (346 aa) |
| | ADU35512.1 | KEGG: rba:RB3641 putative cycloisomerase. (418 aa) |
| | ADU35518.1 | Transcriptional regulator, RpiR family; PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: vei:Veis_3330 RpiR family transcriptional regulator. (305 aa) |
| | ADU35522.1 | 6-phosphogluconolactonase; KEGG: rsl:RPSI07_3329 putative 6-phosphogluconolactonase (pgl). (419 aa) |
| | ADU35586.1 | Manually curated; TIGRFAM: riboflavin biosynthesis protein RibF; KEGG: vap:Vapar_1269 bifunctional riboflavin kinase/FMN adenylyltransferase; PFAM: FAD synthetase; Riboflavin kinase; Belongs to the ribF family. (349 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (198 aa) |
| | ADU35614.1 | PFAM: NUDIX hydrolase; KEGG: vap:Vapar_1297 NUDIX hydrolase. (192 aa) |
| | ADU35634.1 | TIGRFAM: aspartate carbamoyltransferase; KEGG: vap:Vapar_5513 aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (432 aa) |
| | ADU35669.1 | PFAM: nucleoside 2-deoxyribosyltransferase; KEGG: vap:Vapar_3545 nucleoside 2-deoxyribosyltransferase. (180 aa) |
| | ADU35737.1 | Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily. (193 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (343 aa) |
| | ADU35761.1 | PFAM: protein of unknown function DUF45; KEGG: vap:Vapar_1408 protein of unknown function DUF45. (176 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | ADU35789.1 | PFAM: HpcH/HpaI aldolase; KEGG: vap:Vapar_1434 HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family. (360 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (425 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: vap:Vapar_1465 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein. (346 aa) |
| | ADU35843.1 | PFAM: NUDIX hydrolase; KEGG: vap:Vapar_1477 NUDIX hydrolase. (246 aa) |
| | ADU35851.1 | KEGG: vap:Vapar_1485 opine dehydrogenase; PFAM: NAD/NADP octopine/nopaline dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein. (357 aa) |
| | guaC | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (325 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (618 aa) |
| | phnW | 2-aminoethylphosphonate/pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. (377 aa) |
| | ADU36005.1 | PFAM: molybdopterin binding domain; KEGG: vap:Vapar_1631 molybdopterin binding domain protein. (270 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (280 aa) |
| | ADU36039.1 | KEGG: vap:Vapar_1681 adenosine deaminase; PFAM: adenosine/AMP deaminase. (363 aa) |
| | ADU36046.1 | KEGG: eum:ECUMN_3429 hypothetical protein. (238 aa) |
| | ADU36070.1 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (473 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (295 aa) |
| | ADU36099.1 | KEGG: vap:Vapar_1718 6-phosphogluconolactonase. (354 aa) |
| | ADU36124.1 | PFAM: phospholipase D/Transphosphatidylase; KEGG: vap:Vapar_1743 phospholipase D/transphosphatidylase. (459 aa) |
| | pncB | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (406 aa) |
| | ADU36168.1 | TIGRFAM: CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; KEGG: vap:Vapar_1784 CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (188 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (252 aa) |
| | ADU36295.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: vap:Vapar_1826 glyoxalase/bleomycin resistance protein/dioxygenase. (123 aa) |
| | ADU36302.1 | TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; KEGG: vap:Vapar_1833 molybdopterin-guanine dinucleotide biosynthesis protein B. (181 aa) |
| | ADU36303.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (429 aa) |
| | ADU36304.1 | PFAM: thiamineS protein; KEGG: vap:Vapar_1835 molybdopterin converting factor, subunit 1. (83 aa) |
| | ADU36306.1 | PFAM: molybdopterin biosynthesis MoaE protein; KEGG: vap:Vapar_1837 molybdopterin biosynthesis MoaE protein. (158 aa) |
| | ADU36370.1 | KEGG: vap:Vapar_3449 NAD metabolism ATPase/kinase-like protein. (226 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (559 aa) |
| | ADU36377.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (407 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (148 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (499 aa) |
| | ADU36429.1 | KEGG: vap:Vapar_3397 glycerol-3-phosphate dehydrogenase; PFAM: FAD dependent oxidoreductase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (556 aa) |
| | ADU36513.1 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: gur:Gura_0733 glyoxalase/bleomycin resistance protein/dioxygenase. (123 aa) |
| | ADU36549.1 | KEGG: vap:Vapar_3283 phosphoesterase PA-phosphatase related; PFAM: phosphoesterase PA-phosphatase related; SMART: phosphoesterase PA-phosphatase related. (194 aa) |
| | ADU36576.1 | KEGG: pmy:Pmen_3384 phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthase-like protein. (232 aa) |
| | ADU36608.1 | PFAM: Phosphoglycerate mutase; KEGG: vap:Vapar_3235 phosphoglycerate mutase. (213 aa) |
| | ADU36611.1 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: vap:Vapar_3234 CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (212 aa) |
| | ADU36717.1 | Molybdenum cofactor synthesis domain protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (438 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (218 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (386 aa) |
| | ADU36726.1 | KEGG: vap:Vapar_2346 phospholipase D/transphosphatidylase; PFAM: phospholipase D/Transphosphatidylase; SMART: phospholipase D/Transphosphatidylase. (524 aa) |
| | nadE-2 | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (565 aa) |
| | ADU36746.1 | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (135 aa) |
| | ADU36755.1 | KEGG: vap:Vapar_2372 CDP-diacylglycerol/serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol/serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (274 aa) |
| | ADU36802.1 | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (314 aa) |
| | thiG | Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (274 aa) |
| | ADU36804.1 | KEGG: vap:Vapar_2397 thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein. (68 aa) |
| | ADU36806.1 | KEGG: vap:Vapar_2399 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1. (292 aa) |
| | ADU36808.1 | KEGG: vap:Vapar_0108 adenylate/guanylate cyclase with integral membrane sensor; PFAM: adenylyl cyclase class-3/4/guanylyl cyclase; histidine kinase HAMP region domain protein; SMART: adenylyl cyclase class-3/4/guanylyl cyclase. (679 aa) |
| | ADU36844.1 | PFAM: fructose-bisphosphate aldolase class-I; KEGG: vap:Vapar_2993 fructose-bisphosphate aldolase. (349 aa) |
