STRINGSTRING
trpA trpA EIG52186.1 EIG52186.1 EIG51891.1 EIG51891.1 aroC aroC aroQ aroQ trpB-2 trpB-2 EIG53825.1 EIG53825.1 EIG53984.1 EIG53984.1 EIG54150.1 EIG54150.1 aroK aroK EIG54469.1 EIG54469.1 aroE aroE aroK-2 aroK-2 EIG55122.1 EIG55122.1 hisC hisC hisC-2 hisC-2 EIG51890.1 EIG51890.1 EIG51853.1 EIG51853.1 EIG51893.1 EIG51893.1 EIG51894.1 EIG51894.1 EIG51895.1 EIG51895.1 aroA-2 aroA-2 trpD trpD EIG51898.1 EIG51898.1 trpF trpF trpB trpB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (256 aa)
EIG52186.1PFAM: Aminotransferase class I and II. (391 aa)
EIG51891.1PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II. (396 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (350 aa)
aroQ3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa)
trpB-2Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (447 aa)
EIG53825.1PFAM: Aminotransferase class I and II. (394 aa)
EIG53984.1PFAM: 3-dehydroquinate synthase. (388 aa)
EIG54150.1MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa)
EIG54469.1PFAM: Aminotransferase class I and II. (394 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (270 aa)
aroK-2Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa)
EIG55122.1Putative membrane protein; PFAM: Fusaric acid resistance protein family. (360 aa)
hisCPFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (372 aa)
hisC-2PLP-dependent enzyme, histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (380 aa)
EIG51890.1PFAM: 3-dehydroquinate synthase. (324 aa)
EIG51853.1PFAM: Aminotransferase class I and II. (382 aa)
EIG51893.1PFAM: Prephenate dehydrogenase. (300 aa)
EIG51894.1PFAM: chorismate binding enzyme; Anthranilate synthase component I, N terminal region. (472 aa)
EIG51895.1Glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase; PFAM: Glutamine amidotransferase class-I. (190 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (440 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (336 aa)
EIG51898.1PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (257 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (231 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (396 aa)
Your Current Organism:
Desulfovibrio sp. U5L
NCBI taxonomy Id: 596152
Other names: D. sp. U5L
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