(40 nodes) Pyruvate metabolism, and Butanoate metabolism network (Porphyromonas uenonis 603)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EEK17596.1	Succinate CoA transferase; Identified by match to protein family HMM PF02550; match to protein family HMM TIGR03458. (493 aa)
	EEK16294.1	LAO/AO transport system ATPase; Identified by match to protein family HMM PF03308; match to protein family HMM TIGR00750. (367 aa)
	EEK17649.1	Sodium ion-translocating decarboxylase, beta subunit; Identified by match to protein family HMM PF03977; match to protein family HMM TIGR01109. (384 aa)
	EEK16915.1	Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (547 aa)
	ppdK	Pyruvate, phosphate dikinase; Identified by match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828; Belongs to the PEP-utilizing enzyme family. (909 aa)
	maeB	Malate dehydrogenase (oxaloacetate-decarboxylating); Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. (758 aa)
	vorB	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin); Identified by match to protein family HMM PF01855. (359 aa)
	EEK16693.1	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775. (267 aa)
	porG	2-oxoacid:ferredoxin/flavodoxin oxidoreductase, gamma subunit; Identified by match to protein family HMM PF01558. (181 aa)
	nifJ	Pyruvate synthase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176. (1209 aa)
	EEK17145.1	biotin--[acetyl-CoA-carboxylase] ligase; Identified by match to protein family HMM PF03099; match to protein family HMM TIGR00121. (249 aa)
	pckA	Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa)
	mutA	methylmalonyl-CoA mutase, small subunit; Identified by match to protein family HMM PF01642; match to protein family HMM TIGR00642. (623 aa)
	EEK17287.1	methylmalonyl-CoA mutase; Identified by match to protein family HMM PF01642; match to protein family HMM PF02310; match to protein family HMM TIGR00640; match to protein family HMM TIGR00641. (718 aa)
	EEK17304.1	Aldehyde dehydrogenase (NAD) family protein; Identified by match to protein family HMM PF00171. (452 aa)
	EEK17274.1	Alcohol dehydrogenase, iron-dependent; Identified by match to protein family HMM PF00465. (371 aa)
	cat-2	4-hydroxybutyrate coenzyme A transferase; Identified by match to protein family HMM PF02550. (428 aa)
	EEK17315.1	Identified by match to protein family HMM PF01106. (97 aa)
	abfD	Gamma-aminobutyrate metabolism dehydratase/isomerase; Identified by match to protein family HMM PF03241. (491 aa)
	EEK17294.1	Hydrolyase, tartrate alpha subunit/fumarate domain protein, Fe-S type; Identified by match to protein family HMM PF05681; match to protein family HMM TIGR00722. (280 aa)
	fumB	Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Identified by match to protein family HMM PF05683; match to protein family HMM TIGR00723. (185 aa)
	EEK16734.1	Pyruvate synthase; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. (87 aa)
	EEK16727.1	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710. (536 aa)
	orB	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Identified by match to protein family HMM PF02775. (347 aa)
	ackA	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
	pta	Phosphate acetyltransferase; Identified by match to protein family HMM PF01515; match to protein family HMM TIGR00651. (335 aa)
	mce	methylmalonyl-CoA epimerase; Identified by match to protein family HMM PF00903; match to protein family HMM TIGR03081. (138 aa)
	EEK16127.1	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039. (517 aa)
	mmdC	Biotin-requiring enzyme; Identified by match to protein family HMM PF00364. (145 aa)
	sdhC	Succinate dehydrogenase cytochrome B subunit, b558 family; Identified by match to protein family HMM TIGR02046. (268 aa)
	sdhA	Succinate dehydrogenase flavoprotein subunit; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF02910; match to protein family HMM TIGR01811. (647 aa)
	frdB	Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Identified by match to protein family HMM PF00037. (251 aa)
	EEK17479.1	Hypothetical protein. (185 aa)
	aspA	Putative aspartate ammonia-lyase; Identified by match to protein family HMM PF00206. (477 aa)
	EEK16464.1	Hypothetical protein. (391 aa)
	EEK16504.1	Hypothetical protein; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. (64 aa)
	EEK16474.1	Hypothetical protein; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. (115 aa)
	EEK16483.1	Hypothetical protein; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. (402 aa)
	mdh	Lactate/malate dehydrogenase, NAD binding domain protein; Identified by match to protein family HMM PF00056; match to protein family HMM PF02866; Belongs to the LDH/MDH superfamily. (332 aa)
	EEK16791.1	Hypothetical protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error. (74 aa)

Your Current Organism:

Porphyromonas uenonis 603

NCBI taxonomy Id: 596327
Other names: P. uenonis 60-3, Porphyromonas uenonis 60-3, Porphyromonas uenonis str. 60-3, Porphyromonas uenonis strain 60-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEK16127.1	EEK16464.1	PORUE0001_1415	PORUE0001_1719	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Hypothetical protein.	0.620
EEK16127.1	EEK16727.1	PORUE0001_1415	PORUE0001_1259	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	0.624
EEK16127.1	EEK16734.1	PORUE0001_1415	PORUE0001_1258	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Pyruvate synthase; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift.	0.624
EEK16127.1	EEK16915.1	PORUE0001_1415	PORUE0001_0626	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.	0.572
EEK16127.1	EEK17145.1	PORUE0001_1415	PORUE0001_1028	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	biotin--[acetyl-CoA-carboxylase] ligase; Identified by match to protein family HMM PF03099; match to protein family HMM TIGR00121.	0.954
EEK16127.1	EEK17274.1	PORUE0001_1415	PORUE0001_1238	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Alcohol dehydrogenase, iron-dependent; Identified by match to protein family HMM PF00465.	0.438
EEK16127.1	EEK17287.1	PORUE0001_1415	PORUE0001_1189	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	methylmalonyl-CoA mutase; Identified by match to protein family HMM PF01642; match to protein family HMM PF02310; match to protein family HMM TIGR00640; match to protein family HMM TIGR00641.	0.428
EEK16127.1	EEK17304.1	PORUE0001_1415	PORUE0001_1237	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Aldehyde dehydrogenase (NAD) family protein; Identified by match to protein family HMM PF00171.	0.524
EEK16127.1	EEK17649.1	PORUE0001_1415	PORUE0001_0449	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Sodium ion-translocating decarboxylase, beta subunit; Identified by match to protein family HMM PF03977; match to protein family HMM TIGR01109.	0.526
EEK16127.1	ackA	PORUE0001_1415	PORUE0001_1351	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.465
EEK16127.1	frdB	PORUE0001_1415	PORUE0001_1519	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Identified by match to protein family HMM PF00037.	0.502
EEK16127.1	maeB	PORUE0001_1415	PORUE0001_0737	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Malate dehydrogenase (oxaloacetate-decarboxylating); Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	0.614
EEK16127.1	mce	PORUE0001_1415	PORUE0001_1414	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	methylmalonyl-CoA epimerase; Identified by match to protein family HMM PF00903; match to protein family HMM TIGR03081.	0.972
EEK16127.1	mdh	PORUE0001_1415	PORUE0001_1771	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Lactate/malate dehydrogenase, NAD binding domain protein; Identified by match to protein family HMM PF00056; match to protein family HMM PF02866; Belongs to the LDH/MDH superfamily.	0.631
EEK16127.1	mmdC	PORUE0001_1415	PORUE0001_1417	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Biotin-requiring enzyme; Identified by match to protein family HMM PF00364.	0.999
EEK16127.1	mutA	PORUE0001_1415	PORUE0001_1188	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	methylmalonyl-CoA mutase, small subunit; Identified by match to protein family HMM PF01642; match to protein family HMM TIGR00642.	0.428
EEK16127.1	nifJ	PORUE0001_1415	PORUE0001_0886	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Pyruvate synthase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176.	0.956
EEK16127.1	sdhA	PORUE0001_1415	PORUE0001_1518	Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039.	Succinate dehydrogenase flavoprotein subunit; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF02910; match to protein family HMM TIGR01811.	0.474
EEK16294.1	EEK17287.1	PORUE0001_0353	PORUE0001_1189	LAO/AO transport system ATPase; Identified by match to protein family HMM PF03308; match to protein family HMM TIGR00750.	methylmalonyl-CoA mutase; Identified by match to protein family HMM PF01642; match to protein family HMM PF02310; match to protein family HMM TIGR00640; match to protein family HMM TIGR00641.	0.970
EEK16294.1	mce	PORUE0001_0353	PORUE0001_1414	LAO/AO transport system ATPase; Identified by match to protein family HMM PF03308; match to protein family HMM TIGR00750.	methylmalonyl-CoA epimerase; Identified by match to protein family HMM PF00903; match to protein family HMM TIGR03081.	0.752