(22 nodes) Glycolysis / Gluconeogenesis network (Porphyromonas uenonis 603)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	glcK	ROK family protein; Identified by match to protein family HMM PF00480. (322 aa)
	eno	Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (441 aa)
	EEK16989.1	Hypothetical protein. (281 aa)
	gap	Glyceraldehyde-3-phosphate dehydrogenase, type I; Identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
	pgi	Glucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family. (455 aa)
	gpmA	Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa)
	lpdA	Dihydrolipoyl dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350. (456 aa)
	pgk	Phosphoglycerate kinase; Identified by match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (423 aa)
	manB	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Identified by match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. (583 aa)
	ppdK	Pyruvate, phosphate dikinase; Identified by match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828; Belongs to the PEP-utilizing enzyme family. (909 aa)
	fda	Fructose-1,6-bisphosphate aldolase; Identified by match to protein family HMM PF00274; Belongs to the class I fructose-bisphosphate aldolase family. (293 aa)
	vorB	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin); Identified by match to protein family HMM PF01855. (359 aa)
	EEK16693.1	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775. (267 aa)
	nifJ	Pyruvate synthase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176. (1209 aa)
	EEK17097.1	Putative alpha-1,2-mannosidase; Identified by match to protein family HMM PF07971. (627 aa)
	pfkA	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa)
	tpiA	Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
	pckA	Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa)
	EEK16734.1	Pyruvate synthase; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. (87 aa)
	EEK16727.1	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710. (536 aa)
	orB	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Identified by match to protein family HMM PF02775. (347 aa)
	fbp	Firmicute fructose-1,6-bisphosphatase; Identified by match to protein family HMM PF06874. (679 aa)

Your Current Organism:

Porphyromonas uenonis 603

NCBI taxonomy Id: 596327
Other names: P. uenonis 60-3, Porphyromonas uenonis 60-3, Porphyromonas uenonis str. 60-3, Porphyromonas uenonis strain 60-3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEK16693.1	EEK16727.1	PORUE0001_0836	PORUE0001_1259	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	0.999
EEK16693.1	EEK16734.1	PORUE0001_0836	PORUE0001_1258	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	Pyruvate synthase; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift.	0.999
EEK16693.1	lpdA	PORUE0001_0836	PORUE0001_0477	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	Dihydrolipoyl dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350.	0.888
EEK16693.1	nifJ	PORUE0001_0836	PORUE0001_0886	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	Pyruvate synthase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176.	0.999
EEK16693.1	orB	PORUE0001_0836	PORUE0001_1260	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Identified by match to protein family HMM PF02775.	0.899
EEK16693.1	pckA	PORUE0001_0836	PORUE0001_1067	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.	0.851
EEK16693.1	pgi	PORUE0001_0836	PORUE0001_0265	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	Glucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family.	0.861
EEK16693.1	ppdK	PORUE0001_0836	PORUE0001_0646	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	Pyruvate, phosphate dikinase; Identified by match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828; Belongs to the PEP-utilizing enzyme family.	0.891
EEK16693.1	vorB	PORUE0001_0836	PORUE0001_0835	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin); Identified by match to protein family HMM PF01855.	0.999
EEK16727.1	EEK16693.1	PORUE0001_1259	PORUE0001_0836	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	0.999
EEK16727.1	EEK16734.1	PORUE0001_1259	PORUE0001_1258	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	Pyruvate synthase; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift.	0.999
EEK16727.1	gpmA	PORUE0001_1259	PORUE0001_0476	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.	0.614
EEK16727.1	lpdA	PORUE0001_1259	PORUE0001_0477	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	Dihydrolipoyl dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350.	0.669
EEK16727.1	nifJ	PORUE0001_1259	PORUE0001_0886	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	Pyruvate synthase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176.	0.999
EEK16727.1	orB	PORUE0001_1259	PORUE0001_1260	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Identified by match to protein family HMM PF02775.	0.999
EEK16727.1	pckA	PORUE0001_1259	PORUE0001_1067	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.	0.665
EEK16727.1	pgi	PORUE0001_1259	PORUE0001_0265	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	Glucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family.	0.713
EEK16727.1	ppdK	PORUE0001_1259	PORUE0001_0646	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	Pyruvate, phosphate dikinase; Identified by match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828; Belongs to the PEP-utilizing enzyme family.	0.725
EEK16727.1	vorB	PORUE0001_1259	PORUE0001_0835	2-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710.	3-methyl-2-oxobutanoate dehydrogenase (ferredoxin); Identified by match to protein family HMM PF01855.	0.889
EEK16734.1	EEK16693.1	PORUE0001_1258	PORUE0001_0836	Pyruvate synthase; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift.	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775.	0.999