STRINGSTRING
tpiA tpiA prs prs EEK17388.1 EEK17388.1 EEK17048.1 EEK17048.1 EEK16989.1 EEK16989.1 EEK17047.1 EEK17047.1 fhs fhs gap gap EEK17601.1 EEK17601.1 EEK17603.1 EEK17603.1 EEK15967.1 EEK15967.1 dapA dapA serC serC pdxB pdxB pgi pgi prtC prtC EEK16307.1 EEK16307.1 EEK16338.1 EEK16338.1 cobM cobM EEK17649.1 EEK17649.1 EEK17644.1 EEK17644.1 gpmA gpmA lpdA lpdA gdh gdh pgk pgk manB manB gltA gltA dapB dapB pdxH pdxH EEK16889.1 EEK16889.1 EEK16915.1 EEK16915.1 glyA glyA ppdK ppdK EEK16902.1 EEK16902.1 maeB maeB EEK17174.1 EEK17174.1 fda fda vorB vorB EEK16693.1 EEK16693.1 porG porG lysC lysC nifJ nifJ EEK16041.1 EEK16041.1 asd asd EEK16034.1 EEK16034.1 gltX gltX pfkA pfkA EEK17136.1 EEK17136.1 mamA mamA glmE glmE EEK17126.1 EEK17126.1 EEK17156.1 EEK17156.1 rpiB rpiB serB serB EEK17078.1 EEK17078.1 pckA pckA EEK17192.1 EEK17192.1 folD folD EEK17227.1 EEK17227.1 EEK17212.1 EEK17212.1 prtQ prtQ nqrF nqrF rnfC rnfC mutA mutA EEK17287.1 EEK17287.1 EEK17315.1 EEK17315.1 abfD abfD EEK17294.1 EEK17294.1 fumB fumB EEK16734.1 EEK16734.1 EEK16727.1 EEK16727.1 orB orB EEK16596.1 EEK16596.1 fbp fbp ackA ackA pta pta pdxB-2 pdxB-2 mce mce EEK16127.1 EEK16127.1 mmdC mmdC EEK17728.1 EEK17728.1 EEK17713.1 EEK17713.1 EEK17694.1 EEK17694.1 EEK17690.1 EEK17690.1 fsa fsa sdhC sdhC sdhA sdhA frdB frdB hbd hbd EEK17479.1 EEK17479.1 rpe rpe EEK16618.1 EEK16618.1 EEK16619.1 EEK16619.1 EEK16464.1 EEK16464.1 tkt tkt glcK glcK EEK16445.1 EEK16445.1 EEK16504.1 EEK16504.1 EEK16474.1 EEK16474.1 EEK16483.1 EEK16483.1 mdh mdh eno eno hemD hemD EEK17258.1 EEK17258.1 EEK16791.1 EEK16791.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
prsRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa)
EEK17388.1Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family. (166 aa)
EEK17048.1Fibrobacter succinogene major paralogous domain protein; Identified by glimmer; putative. (415 aa)
EEK16989.1Hypothetical protein. (281 aa)
EEK17047.1GH3 auxin-responsive promoter; Identified by match to protein family HMM PF03321. (492 aa)
fhsFormate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase, type I; Identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
EEK17601.1DHHA1 domain protein; Identified by match to protein family HMM PF01368; match to protein family HMM PF02272. (360 aa)
EEK17603.1Hypothetical protein. (159 aa)
EEK15967.1Integrase core domain protein; Identified by match to protein family HMM PF00665. (368 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (314 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa)
pdxB4-phosphoerythronate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (306 aa)
pgiGlucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family. (455 aa)
prtCPeptidase, U32 family; Identified by match to protein family HMM PF01136. (446 aa)
EEK16307.1Putative iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037; match to protein family HMM PF08331. (297 aa)
EEK16338.1PepSY domain protein; Identified by match to protein family HMM PF03929. (491 aa)
cobMPrecorrin-4 C(11)-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM PF01890; match to protein family HMM TIGR01465. (611 aa)
EEK17649.1Sodium ion-translocating decarboxylase, beta subunit; Identified by match to protein family HMM PF03977; match to protein family HMM TIGR01109. (384 aa)
EEK17644.1Sodium pump decarboxylase, gamma subunit. (315 aa)
gpmAPhosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa)
lpdADihydrolipoyl dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350. (456 aa)
gdhGlutamate dehydrogenase, NAD-specific; Identified by match to protein family HMM PF00208; match to protein family HMM PF02812; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa)
pgkPhosphoglycerate kinase; Identified by match to protein family HMM PF00162; Belongs to the phosphoglycerate kinase family. (423 aa)
manBPhosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Identified by match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880. (583 aa)
gltAGlutamate synthase (NADPH), homotetrameric; Identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01316. (491 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (255 aa)
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (215 aa)
EEK16889.1Bacterial transferase hexapeptide repeat protein; Identified by match to protein family HMM PF00132. (152 aa)
EEK16915.1Hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (547 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
ppdKPyruvate, phosphate dikinase; Identified by match to protein family HMM PF00391; match to protein family HMM PF01326; match to protein family HMM PF02896; match to protein family HMM TIGR01828; Belongs to the PEP-utilizing enzyme family. (909 aa)
EEK16902.1Rhodanese-like protein. (142 aa)
maeBMalate dehydrogenase (oxaloacetate-decarboxylating); Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949. (758 aa)
EEK17174.1PepSY domain protein; Identified by match to protein family HMM PF03929. (502 aa)
fdaFructose-1,6-bisphosphate aldolase; Identified by match to protein family HMM PF00274; Belongs to the class I fructose-bisphosphate aldolase family. (293 aa)
vorB3-methyl-2-oxobutanoate dehydrogenase (ferredoxin); Identified by match to protein family HMM PF01855. (359 aa)
EEK16693.1Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by match to protein family HMM PF02775. (267 aa)
porG2-oxoacid:ferredoxin/flavodoxin oxidoreductase, gamma subunit; Identified by match to protein family HMM PF01558. (181 aa)
lysCAmino acid kinase family; Identified by match to protein family HMM PF00696; match to protein family HMM TIGR00657; Belongs to the aspartokinase family. (458 aa)
nifJPyruvate synthase; Identified by match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176. (1209 aa)
EEK16041.12-phosphosulfolactate phosphatase; Identified by match to protein family HMM PF04029; Belongs to the ComB family. (240 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa)
EEK16034.1Identified by match to protein family HMM PF02566. (132 aa)
gltXglutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (527 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa)
EEK17136.1Hypothetical protein. (433 aa)
mamAMethylaspartate mutase, S subunit; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (137 aa)
glmEMethylaspartate mutase, E subunit; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (482 aa)
EEK17126.1Methylaspartate ammonia-lyase; Identified by match to protein family HMM PF05034; match to protein family HMM PF07476; match to protein family HMM TIGR01502. (414 aa)
EEK17156.1Hypothetical protein; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF08984. (85 aa)
rpiBRibose-5-phosphate isomerase B; Identified by match to protein family HMM PF02502; match to protein family HMM TIGR00689; match to protein family HMM TIGR01120. (145 aa)
serBPhosphoserine phosphatase SerB; Identified by match to protein family HMM PF00702; match to protein family HMM PF01842; match to protein family HMM PF08282; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. (429 aa)
EEK17078.1Hypothetical protein. (432 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (537 aa)
EEK17192.1Transporter, CPA2 family; Identified by match to protein family HMM PF00999. (802 aa)
folDTetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (297 aa)
EEK17227.1Hypothetical protein. (156 aa)
EEK17212.1Hypothetical protein. (140 aa)
prtQPeptidase, U32 family; Identified by match to protein family HMM PF01136. (648 aa)
nqrFNADH:ubiquinone oxidoreductase, F subunit; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway. (415 aa)
rnfCElectron transport complex, RnfABCDGE type, C subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (412 aa)
mutAmethylmalonyl-CoA mutase, small subunit; Identified by match to protein family HMM PF01642; match to protein family HMM TIGR00642. (623 aa)
EEK17287.1methylmalonyl-CoA mutase; Identified by match to protein family HMM PF01642; match to protein family HMM PF02310; match to protein family HMM TIGR00640; match to protein family HMM TIGR00641. (718 aa)
EEK17315.1Identified by match to protein family HMM PF01106. (97 aa)
abfDGamma-aminobutyrate metabolism dehydratase/isomerase; Identified by match to protein family HMM PF03241. (491 aa)
EEK17294.1Hydrolyase, tartrate alpha subunit/fumarate domain protein, Fe-S type; Identified by match to protein family HMM PF05681; match to protein family HMM TIGR00722. (280 aa)
fumBHydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type; Identified by match to protein family HMM PF05683; match to protein family HMM TIGR00723. (185 aa)
EEK16734.1Pyruvate synthase; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. (87 aa)
EEK16727.12-oxoacid:acceptor oxidoreductase, alpha subunit; Overlaps another CDS with the same product name; an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01855; match to protein family HMM TIGR03710. (536 aa)
orB2-oxoglutarate ferredoxin oxidoreductase subunit beta; Identified by match to protein family HMM PF02775. (347 aa)
EEK16596.1Putative FeS assembly SUF system protein; Identified by match to protein family HMM PF01883. (104 aa)
fbpFirmicute fructose-1,6-bisphosphatase; Identified by match to protein family HMM PF06874. (679 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
ptaPhosphate acetyltransferase; Identified by match to protein family HMM PF01515; match to protein family HMM TIGR00651. (335 aa)
pdxB-24-phosphoerythronate dehydrogenase; Identified by match to protein family HMM PF00389; match to protein family HMM PF02826; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
mcemethylmalonyl-CoA epimerase; Identified by match to protein family HMM PF00903; match to protein family HMM TIGR03081. (138 aa)
EEK16127.1Carboxyl transferase domain protein; Identified by match to protein family HMM PF01039. (517 aa)
mmdCBiotin-requiring enzyme; Identified by match to protein family HMM PF00364. (145 aa)
EEK17728.13-oxoacid CoA-transferase, A subunit; Identified by match to protein family HMM PF01144; match to protein family HMM TIGR02429. (214 aa)
EEK17713.13-oxoacid CoA-transferase, B subunit; Identified by match to protein family HMM PF01144; match to protein family HMM TIGR02428. (222 aa)
EEK17694.1acyl-CoA dehydrogenase, C-terminal domain protein; Identified by match to protein family HMM PF00441; match to protein family HMM PF02770; match to protein family HMM PF02771; match to protein family HMM PF08028. (379 aa)
EEK17690.13-hydroxybutyryl-CoA dehydrogenase; Identified by match to protein family HMM PF00725; match to protein family HMM PF02737. (282 aa)
fsaFructose-6-phosphate aldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (221 aa)
sdhCSuccinate dehydrogenase cytochrome B subunit, b558 family; Identified by match to protein family HMM TIGR02046. (268 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Identified by match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF02910; match to protein family HMM TIGR01811. (647 aa)
frdBSuccinate dehydrogenase/fumarate reductase iron-sulfur subunit; Identified by match to protein family HMM PF00037. (251 aa)
hbd3-hydroxybutyryl-CoA dehydrogenase; Identified by match to protein family HMM PF00725; match to protein family HMM PF02737. (313 aa)
EEK17479.1Hypothetical protein. (185 aa)
rpeRibulose-phosphate 3-epimerase; Identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; Belongs to the ribulose-phosphate 3-epimerase family. (215 aa)
EEK16618.1Integrase core domain protein; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00665. (316 aa)
EEK16619.1Hypothetical protein; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop. (171 aa)
EEK16464.1Hypothetical protein. (391 aa)
tktTransketolase, thiamine diphosphate binding domain protein; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780; Belongs to the transketolase family. (695 aa)
glcKROK family protein; Identified by match to protein family HMM PF00480. (322 aa)
EEK16445.1Hypothetical protein. (245 aa)
EEK16504.1Hypothetical protein; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. (64 aa)
EEK16474.1Hypothetical protein; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. (115 aa)
EEK16483.1Hypothetical protein; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. (402 aa)
mdhLactate/malate dehydrogenase, NAD binding domain protein; Identified by match to protein family HMM PF00056; match to protein family HMM PF02866; Belongs to the LDH/MDH superfamily. (332 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (441 aa)
hemDuroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (251 aa)
EEK17258.1Hypothetical protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error. (43 aa)
EEK16791.1Hypothetical protein; This gene contains a nucleotide ambiguity which may be the result of a sequencing error. (74 aa)
Your Current Organism:
Porphyromonas uenonis 603
NCBI taxonomy Id: 596327
Other names: P. uenonis 60-3, Porphyromonas uenonis 60-3, Porphyromonas uenonis str. 60-3, Porphyromonas uenonis strain 60-3
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