55 items (Taeniopygia guttata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MATK	Tyrosine-protein kinase. (443 aa)
	SYK	Tyrosine-protein kinase. (668 aa)
	INSR	Insulin receptor. (1323 aa)
	SHC3	SHC adaptor protein 3. (632 aa)
	ITK	Tyrosine-protein kinase. (631 aa)
	LCK	Protein kinase domain-containing protein. (513 aa)
	LCP2	Lymphocyte cytosolic protein 2. (530 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1322 aa)
	GAB1	GRB2 associated binding protein 1. (720 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1223 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (846 aa)
	MST1R	Macrophage stimulating 1 receptor. (1419 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1385 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (582 aa)
	SH3KBP1	SH3 domain containing kinase binding protein 1. (704 aa)
	GRB10	Growth factor receptor bound protein 10. (596 aa)
	IRS1	Insulin receptor substrate 1. (1233 aa)
	LOC100221185	Uncharacterized protein. (738 aa)
	GRB2	Putative growth factor receptor-bound protein 2. (217 aa)
	IRS2	Insulin receptor substrate 2. (1192 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1363 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (137 aa)
	YES1	Tyrosine-protein kinase. (541 aa)
	RAC2	Rac family small GTPase 2. (206 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1244 aa)
	CD2AP	CD2 associated protein. (637 aa)
	H0ZT70_TAEGU	KIND domain-containing protein. (632 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1604 aa)
	CBLB	Cbl proto-oncogene B. (1025 aa)
	PTPN1	Tyrosine-protein phosphatase non-receptor type 1. (432 aa)
	BTK	Tyrosine-protein kinase. (662 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (481 aa)
	SHC1	SHC adaptor protein 1. (609 aa)
	ENSTGUP00000019835	annotation not available (1860 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1054 aa)
	GRAP	Uncharacterized protein. (358 aa)
	PIK3R2	Uncharacterized protein. (727 aa)
	LOC100222362	Phosphoinositide phospholipase C. (1311 aa)
	BLNK	Uncharacterized protein. (601 aa)
	PIK3CB	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	LOC100225168	Tyrosine-protein kinase CSK. (450 aa)
	LYN	Tyrosine-protein kinase. (605 aa)
	TXK	TXK tyrosine kinase. (546 aa)
	IRS4	Uncharacterized protein. (1150 aa)
	ENSTGUP00000027661	annotation not available (73 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (878 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (555 aa)
	CBL	Uncharacterized protein. (871 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (497 aa)
	ENSTGUP00000034337	annotation not available (812 aa)
	GRAP2	Uncharacterized protein. (296 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (529 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	FYN	ENSTGUP00000031570	ENSTGUP00000021967	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.552
AKT1	GRB2	ENSTGUP00000031570	ENSTGUP00000008899	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Putative growth factor receptor-bound protein 2.	0.403
AKT1	INS	ENSTGUP00000031570	ENSTGUP00000009610	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.486
AKT1	LCK	ENSTGUP00000031570	ENSTGUP00000001461	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.474
AKT1	LOC100221185	ENSTGUP00000031570	ENSTGUP00000008408	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.956
AKT1	LOC100225168	ENSTGUP00000031570	ENSTGUP00000022369	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase CSK.	0.451
AKT1	LYN	ENSTGUP00000031570	ENSTGUP00000024943	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.488
AKT1	MATK	ENSTGUP00000031570	ENSTGUP00000000136	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.452
AKT1	PDPK1	ENSTGUP00000031570	ENSTGUP00000029735	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	3-phosphoinositide dependent protein kinase 1.	0.990
AKT1	PIK3CA	ENSTGUP00000031570	ENSTGUP00000011093	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.965
AKT1	PIK3CB	ENSTGUP00000031570	ENSTGUP00000021600	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.962
AKT1	PIK3CD	ENSTGUP00000031570	ENSTGUP00000019923	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.962
AKT1	PIK3R1	ENSTGUP00000031570	ENSTGUP00000003114	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.956
AKT1	PIK3R2	ENSTGUP00000031570	ENSTGUP00000020249	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.956
AKT1	RAC2	ENSTGUP00000031570	ENSTGUP00000010983	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Rac family small GTPase 2.	0.441
AKT1	SHC1	ENSTGUP00000031570	ENSTGUP00000019228	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	SHC adaptor protein 1.	0.403
AKT1	SHC3	ENSTGUP00000031570	ENSTGUP00000000470	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	SHC adaptor protein 3.	0.403
AKT1	YES1	ENSTGUP00000031570	ENSTGUP00000010488	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.538
BLNK	BTK	ENSTGUP00000021186	ENSTGUP00000015504	Uncharacterized protein.	Tyrosine-protein kinase.	0.917
BLNK	CBL	ENSTGUP00000021186	ENSTGUP00000030311	Uncharacterized protein.	Uncharacterized protein.	0.637