STRINGSTRING
SMAD2 SMAD2 SMAD7 SMAD7 LOC100220866 LOC100220866 ACVR2B ACVR2B BAMBI BAMBI SMAD5 SMAD5 TEAD3 TEAD3 HECW1 HECW1 INHBA INHBA VGLL1 VGLL1 FST FST SMAD1 SMAD1 MSN MSN SKI SKI PRKCZ PRKCZ LOC100230282 LOC100230282 ITCH ITCH ENG ENG TGFBR2 TGFBR2 GDF5 GDF5 ENSTGUP00000004108 ENSTGUP00000004108 LOC100224677 LOC100224677 VGLL4 VGLL4 LOC100232580 LOC100232580 CRB1 CRB1 MPDZ MPDZ PARD6A PARD6A STK4 STK4 BMPER BMPER BMPR1A BMPR1A TLL1 TLL1 AMOT AMOT INHA INHA AMOTL2 AMOTL2 PUS10 PUS10 TGFBR1 TGFBR1 DTX4 DTX4 TLL2 TLL2 SMURF1 SMURF1 GDF2 GDF2 GDF10 GDF10 WWP2 WWP2 DRGX DRGX LLGL2 LLGL2 ABITRAM ABITRAM MSANTD3 MSANTD3 NR4A3 NR4A3 PARD6G PARD6G ZFYVE9 ZFYVE9 SMAD6 SMAD6 NOG NOG TWSG1 TWSG1 BMPR2 BMPR2 CHRD CHRD NF2 NF2 HECW2 HECW2 MSTN MSTN FGF14 FGF14 SKIL SKIL EZR EZR LATS1 LATS1 WWTR1 WWTR1 WWP1 WWP1 SMAD9 SMAD9 GOPC GOPC ACVR2A ACVR2A SLA SLA BMP5 BMP5 USP35 USP35 TEAD4 TEAD4 LLGL1 LLGL1 INHBC INHBC ZFYVE16 ZFYVE16 LOC100217480 LOC100217480 GREM1 GREM1 BMP6 BMP6 FSTL3 FSTL3 LOC115491418 LOC115491418 ENSTGUP00000020434 ENSTGUP00000020434 H0ZXQ5_TAEGU H0ZXQ5_TAEGU PARD3 PARD3 GDF1 GDF1 LOC115491405 LOC115491405 COL6A3 COL6A3 RHOJ RHOJ SMURF2 SMURF2 TMEFF1 TMEFF1 PLEKHA7 PLEKHA7 FRMD1 FRMD1 HIVEP3 HIVEP3 NDFIP2 NDFIP2 PODXL PODXL BMP4 BMP4 INSM2 INSM2 CFTR CFTR LOC100230978 LOC100230978 H0ZCZ9_TAEGU H0ZCZ9_TAEGU LOC100230322 LOC100230322 SMAD3 SMAD3 LOC115497907 LOC115497907 MPP3 MPP3 BMP2 BMP2 H0Z191_TAEGU H0Z191_TAEGU ACVR1B ACVR1B MOB1B MOB1B GDF6 GDF6 ACVR1 ACVR1 EPB41L5 EPB41L5 H0Z984_TAEGU H0Z984_TAEGU DTX1 DTX1 SLC9A3R1 SLC9A3R1 LOC100221634 LOC100221634 STK3 STK3 NUMB NUMB ENSTGUP00000028843 ENSTGUP00000028843 LOC115498224 LOC115498224 CRB2 CRB2 ENSTGUP00000029281 ENSTGUP00000029281 TGFB3 TGFB3 RDX RDX BMP7 BMP7 ENSTGUP00000031898 ENSTGUP00000031898 PATJ PATJ GDF7 GDF7 SMAD4 SMAD4 AMHR2 AMHR2 NBL1 NBL1 SLC9A3R2 SLC9A3R2 MPP7 MPP7 BMPR1B BMPR1B LNX2 LNX2 AMOTL1 AMOTL1 ENSTGUP00000035454 ENSTGUP00000035454 ENSTGUP00000035464 ENSTGUP00000035464 H0Z4A8_TAEGU H0Z4A8_TAEGU PARD3B PARD3B PRKCI PRKCI PRKCE PRKCE TEAD1 TEAD1 NEDD4L NEDD4L LATS2 LATS2 SAV1 SAV1 INHBB INHBB ZNF706 ZNF706 NEDD4 NEDD4 MPP5 MPP5 YAP1 YAP1 GREM2 GREM2 ENSTGUP00000038193 ENSTGUP00000038193 ACVR1C ACVR1C BMP10 BMP10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD2Mothers against decapentaplegic homolog. (487 aa)
SMAD7MH1 domain-containing protein. (392 aa)
LOC100220866CFC domain-containing protein. (193 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
BAMBIBMP and activin membrane bound inhibitor. (261 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TEAD3Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (432 aa)
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1614 aa)
INHBAInhibin subunit beta A. (559 aa)
VGLL1Vestigial like family member 1. (159 aa)
FSTFollistatin. (343 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
MSNMoesin. (580 aa)
SKISKI proto-oncogene. (714 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
LOC100230282Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (586 aa)
ITCHE3 ubiquitin-protein ligase. (874 aa)
ENGEndoglin. (631 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
GDF5Growth differentiation factor 5. (500 aa)
ENSTGUP00000004108annotation not available (432 aa)
LOC100224677TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (559 aa)
VGLL4Vestigial like family member 4. (289 aa)
LOC100232580TGF_BETA_2 domain-containing protein. (364 aa)
CRB1Uncharacterized protein. (1407 aa)
MPDZMultiple PDZ domain crumbs cell polarity complex component. (2137 aa)
PARD6APar-6 family cell polarity regulator alpha. (357 aa)
STK4Serine/threonine kinase 4. (533 aa)
BMPERBMP binding endothelial regulator. (679 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
TLL1Metalloendopeptidase. (1044 aa)
AMOTAngiomotin. (926 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
AMOTL2Angiomotin like 2. (691 aa)
PUS10Pseudouridine synthase 10. (592 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (501 aa)
DTX4Deltex E3 ubiquitin ligase 4. (617 aa)
TLL2Metalloendopeptidase. (1010 aa)
SMURF1E3 ubiquitin-protein ligase. (737 aa)
GDF2Growth differentiation factor 2. (428 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (459 aa)
WWP2E3 ubiquitin-protein ligase. (877 aa)
DRGXDorsal root ganglia homeobox. (260 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1025 aa)
ABITRAMActin binding transcription modulator. (203 aa)
MSANTD3Myb/SANT DNA binding domain containing 3. (274 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (601 aa)
PARD6GPar-6 family cell polarity regulator gamma. (568 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1410 aa)
SMAD6SMAD family member 6. (477 aa)
NOGNoggin; Belongs to the noggin family. (223 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (222 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1036 aa)
CHRDChordin. (1135 aa)
NF2Neurofibromin 2. (595 aa)
HECW2Uncharacterized protein. (1562 aa)
MSTNMyostatin. (375 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
SKILSKI like proto-oncogene. (691 aa)
EZREzrin. (586 aa)
LATS1Large tumor suppressor kinase 1. (1138 aa)
WWTR1WW domain containing transcription regulator 1. (382 aa)
WWP1E3 ubiquitin-protein ligase. (925 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
GOPCPDZ domain-containing protein. (631 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
SLASrc like adaptor. (270 aa)
BMP5Bone morphogenetic protein 5. (453 aa)
USP35Ubiquitin carboxyl-terminal hydrolase. (996 aa)
TEAD4TEA domain transcription factor 4. (492 aa)
LLGL1Lgl_C domain-containing protein. (1106 aa)
INHBCInhibin subunit beta C. (449 aa)
ZFYVE16FYVE-type domain-containing protein. (1520 aa)
LOC100217480TGF_BETA_2 domain-containing protein. (376 aa)
GREM1Gremlin. (184 aa)
BMP6Bone morphogenetic protein 6. (414 aa)
FSTL3Follistatin-related protein 3. (246 aa)
LOC115491418Growth differentiation factor 11. (377 aa)
ENSTGUP00000020434annotation not available (505 aa)
H0ZXQ5_TAEGUProtein kinase domain-containing protein. (326 aa)
PARD3Par-3 family cell polarity regulator. (1350 aa)
GDF1TGF_BETA_2 domain-containing protein. (351 aa)
LOC115491405Serine/threonine-protein kinase receptor R3 isoform X2. (493 aa)
COL6A3Collagen type VI alpha 3 chain. (2603 aa)
RHOJRas homolog family member J. (289 aa)
SMURF2E3 ubiquitin-protein ligase. (777 aa)
TMEFF1Uncharacterized protein. (397 aa)
PLEKHA7PH domain-containing protein. (1477 aa)
FRMD1FERM domain containing 1. (565 aa)
HIVEP3Human immunodeficiency virus type I enhancer binding protein 3. (2290 aa)
NDFIP2Nedd4 family interacting protein 2. (302 aa)
PODXLUncharacterized protein. (602 aa)
BMP4Bone morphogenetic protein 4. (420 aa)
INSM2INSM transcriptional repressor 2. (402 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1485 aa)
LOC100230978FERM domain-containing protein. (660 aa)
H0ZCZ9_TAEGUTGF_BETA_2 domain-containing protein. (439 aa)
LOC100230322Uncharacterized protein. (680 aa)
SMAD3Putative mothers against decapentaplegic 3. (445 aa)
LOC115497907Par-6 family cell polarity regulator beta. (372 aa)
MPP3Membrane palmitoylated protein 3; Belongs to the MAGUK family. (332 aa)
BMP2Bone morphogenetic protein 2. (398 aa)
H0Z191_TAEGUMothers against decapentaplegic homolog. (343 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (516 aa)
MOB1BUncharacterized protein. (216 aa)
GDF6Growth differentiation factor 6. (318 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (647 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (766 aa)
H0Z984_TAEGUPeptidylprolyl isomerase. (287 aa)
DTX1LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase DTX1. (608 aa)
SLC9A3R1SLC9A3 regulator 1. (333 aa)
LOC100221634Partitioning defective 6 homolog beta. (372 aa)
STK3Serine/threonine kinase 3. (510 aa)
NUMBNUMB endocytic adaptor protein. (671 aa)
ENSTGUP00000028843annotation not available (398 aa)
LOC115498224TGF_BETA_2 domain-containing protein. (386 aa)
CRB2Uncharacterized protein. (1464 aa)
ENSTGUP00000029281annotation not available (729 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (533 aa)
RDXRadixin. (594 aa)
BMP7Bone morphogenetic protein 7. (459 aa)
ENSTGUP00000031898annotation not available (641 aa)
PATJUncharacterized protein. (1813 aa)
GDF7Growth differentiation factor 7. (369 aa)
SMAD4SMAD family member 4. (514 aa)
AMHR2LOW QUALITY PROTEIN: anti-Muellerian hormone type-2 receptor. (574 aa)
NBL1Neuroblastoma suppressor of tumorigenicity 1. (196 aa)
SLC9A3R2SLC9A3 regulator 2. (551 aa)
MPP7Membrane palmitoylated protein 7; Belongs to the MAGUK family. (597 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
LNX2Ligand of numb-protein X 2. (687 aa)
AMOTL1Angiomotin like 1. (964 aa)
ENSTGUP00000035454annotation not available (786 aa)
ENSTGUP00000035464Inhibin beta C chain. (514 aa)
H0Z4A8_TAEGUCENP-T_C domain-containing protein. (640 aa)
PARD3BPar-3 family cell polarity regulator beta. (1201 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (470 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (743 aa)
TEAD1Transcriptional enhancer factor TEF-1 isoform X4. (442 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1284 aa)
LATS2Non-specific serine/threonine protein kinase. (1153 aa)
SAV1Salvador family WW domain containing protein 1. (379 aa)
INHBBInhibin beta B chain. (392 aa)
ZNF706Zinc finger protein 706. (109 aa)
NEDD4E3 ubiquitin-protein ligase. (1302 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
YAP1Uncharacterized protein. (504 aa)
GREM2Gremlin 2, DAN family BMP antagonist. (341 aa)
ENSTGUP00000038193annotation not available (413 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (363 aa)
BMP10Bone morphogenetic protein 10. (425 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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