STRINGSTRING
SMAD2 SMAD2 SMAD7 SMAD7 BAMBI BAMBI SMAD5 SMAD5 SMAD1 SMAD1 SKI SKI LOC100230282 LOC100230282 ITCH ITCH ENG ENG TGFBR2 TGFBR2 ENSTGUP00000004108 ENSTGUP00000004108 LOC100224677 LOC100224677 TGFBR1 TGFBR1 SMURF1 SMURF1 GDF2 GDF2 ZFYVE9 ZFYVE9 SMAD6 SMAD6 SKIL SKIL SMAD9 SMAD9 ZFYVE16 ZFYVE16 ENSTGUP00000020434 ENSTGUP00000020434 LOC115491405 LOC115491405 SMURF2 SMURF2 SMAD3 SMAD3 H0Z191_TAEGU H0Z191_TAEGU ACVR1 ACVR1 H0Z984_TAEGU H0Z984_TAEGU ENSTGUP00000028843 ENSTGUP00000028843 TGFB3 TGFB3 ENSTGUP00000031898 ENSTGUP00000031898 SMAD4 SMAD4 NEDD4L NEDD4L NEDD4 NEDD4 ACVR1C ACVR1C BMP10 BMP10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD2Mothers against decapentaplegic homolog. (487 aa)
SMAD7MH1 domain-containing protein. (392 aa)
BAMBIBMP and activin membrane bound inhibitor. (261 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SKISKI proto-oncogene. (714 aa)
LOC100230282Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (586 aa)
ITCHE3 ubiquitin-protein ligase. (874 aa)
ENGEndoglin. (631 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
ENSTGUP00000004108annotation not available (432 aa)
LOC100224677TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (559 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (501 aa)
SMURF1E3 ubiquitin-protein ligase. (737 aa)
GDF2Growth differentiation factor 2. (428 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1410 aa)
SMAD6SMAD family member 6. (477 aa)
SKILSKI like proto-oncogene. (691 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
ZFYVE16FYVE-type domain-containing protein. (1520 aa)
ENSTGUP00000020434annotation not available (505 aa)
LOC115491405Serine/threonine-protein kinase receptor R3 isoform X2. (493 aa)
SMURF2E3 ubiquitin-protein ligase. (777 aa)
SMAD3Putative mothers against decapentaplegic 3. (445 aa)
H0Z191_TAEGUMothers against decapentaplegic homolog. (343 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (647 aa)
H0Z984_TAEGUPeptidylprolyl isomerase. (287 aa)
ENSTGUP00000028843annotation not available (398 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (533 aa)
ENSTGUP00000031898annotation not available (641 aa)
SMAD4SMAD family member 4. (514 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1284 aa)
NEDD4E3 ubiquitin-protein ligase. (1302 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (363 aa)
BMP10Bone morphogenetic protein 10. (425 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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