(136 nodes) Cytokine-mediated signaling pathway, and Regulation of interleukin-17 production network (Taeniopygia guttata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (312 aa)
	IL10RA	Interleukin 10 receptor subunit alpha. (574 aa)
	IL17B	Interleukin 17B. (214 aa)
	ACKR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (413 aa)
	IL18	Interleukin-18. (192 aa)
	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif 10. (1106 aa)
	GRK6	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (560 aa)
	H0YQI8_TAEGU	Fibronectin type-III domain-containing protein. (323 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (604 aa)
	IL19	Interleukin 19. (177 aa)
	IL10	Interleukin 10. (165 aa)
	H0YT16_TAEGU	Uncharacterized protein. (130 aa)
	LOC100223328	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (95 aa)
	LOC100222345	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
	CXCL8	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (107 aa)
	IL7R	Interleukin 7 receptor. (460 aa)
	LOC100222957	Uncharacterized protein. (305 aa)
	LIFR	LIF receptor subunit alpha. (1166 aa)
	OSMR	Uncharacterized protein. (951 aa)
	PROSER2	Uncharacterized protein. (474 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	STAT3	Signal transducer and activator of transcription. (811 aa)
	IL6	Interleukin 6. (221 aa)
	IL13RA1	Fibronectin type-III domain-containing protein. (422 aa)
	SOCS3	Suppressor of cytokine signaling 3. (209 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (299 aa)
	H0Z078_TAEGU	Uncharacterized protein. (188 aa)
	LOC100228379	Uncharacterized protein. (184 aa)
	XCR1	X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (334 aa)
	CCR9	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	IL20RB	Interleukin 20 receptor subunit beta. (307 aa)
	SOCS1	Suppressor of cytokine signaling 1. (207 aa)
	CRLF3	Cytokine receptor like factor 3. (442 aa)
	LOC115497720	SCY domain-containing protein. (91 aa)
	JAK2	Tyrosine-protein kinase. (1130 aa)
	DMRT2	Doublesex and mab-3 related transcription factor 2. (502 aa)
	IL22	Interleukin 22. (194 aa)
	CNTF	Ciliary neurotrophic factor. (195 aa)
	IL17RD	Interleukin 17 receptor D. (742 aa)
	IL13RA2	Interleukin 13 receptor subunit alpha 2. (379 aa)
	ZC3H18	Zinc finger CCCH-type containing 18. (982 aa)
	IL17C	Interleukin 17C. (217 aa)
	IL17RC	Uncharacterized protein. (723 aa)
	FKBP7	Peptidylprolyl isomerase. (218 aa)
	IL1RAP	Uncharacterized protein. (691 aa)
	IL4R	Fibronectin type-III domain-containing protein. (887 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	IL18RAP	Interleukin 18 receptor accessory protein. (587 aa)
	IL1RL1	Uncharacterized protein. (541 aa)
	IL1R1	Uncharacterized protein. (563 aa)
	LIF	LIF interleukin 6 family cytokine. (211 aa)
	CRLF2	Cytokine receptor like factor 2. (392 aa)
	STAT1	Signal transducer and activator of transcription. (755 aa)
	IL20RA	Interleukin 20 receptor subunit alpha. (653 aa)
	IL7	Uncharacterized protein. (179 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	AKIRIN2	Akirin 2. (193 aa)
	IL17RA	Interleukin 17 receptor A. (854 aa)
	INF2	Uncharacterized protein. (1353 aa)
	IL17A	Uncharacterized protein. (150 aa)
	LOC100223710	Uncharacterized protein. (179 aa)
	LOC100227529	SCY domain-containing protein. (101 aa)
	STAT6	Signal transducer and activator of transcription 6. (932 aa)
	JAK3	Janus kinase 3. (1113 aa)
	CXCL14	Uncharacterized protein. (98 aa)
	LOC100229435	Uncharacterized protein. (579 aa)
	CCR4	C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	CX3CR1	C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	CXCL12	Putative stromal cell derived factor 1; Belongs to the intercrine alpha (chemokine CxC) family. (203 aa)
	ENSTGUP00000019236	annotation not available (293 aa)
	LOC100229516	SCY domain-containing protein. (145 aa)
	IL2RB	Fibronectin type-III domain-containing protein. (567 aa)
	IFNLR1	Fibronectin type-III domain-containing protein. (565 aa)
	EBI3	Interleukin-27 subunit beta. (340 aa)
	STAT2	Signal transducer and activator of transcription 2. (976 aa)
	LOC100228920	Tyrosine-protein kinase JAK1. (1225 aa)
	ENSTGUP00000021521	annotation not available (136 aa)
	H0ZIT4_TAEGU	Uncharacterized protein. (954 aa)
	CCR5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	SLC29A4	Solute carrier family 29 member 4. (661 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (396 aa)
	IL18R1	TIR domain-containing protein. (565 aa)
	ENSTGUP00000023651	annotation not available (927 aa)
	PPP1R13B	Uncharacterized protein. (1185 aa)
	IL22RA1	Fibronectin type-III domain-containing protein. (593 aa)
	LOC115497673	Fibronectin type-III domain-containing protein. (501 aa)
	NFKBIZ	ANK_REP_REGION domain-containing protein. (712 aa)
	ZFYVE21	FYVE-type domain-containing protein. (472 aa)
	LOC115497716	Interfer-bind domain-containing protein. (345 aa)
	PPP1R13L	Protein phosphatase 1 regulatory subunit 13 like. (367 aa)
	SOCS4	Suppressor of cytokine signaling 4. (436 aa)
	ENSTGUP00000027497	annotation not available (154 aa)
	IFNGR1	Fibronectin type-III domain-containing protein. (434 aa)
	ENSTGUP00000028147	Interleukin-1 receptor antagonist protein-like. (166 aa)
	IL6R	Interleukin 6 receptor. (460 aa)
	LOC100224671	Interleukin-10 receptor subunit beta. (617 aa)
	ENSTGUP00000029214	Interleukin-36 receptor antagonist protein-like. (175 aa)
	LOC115498169	Interleukin-1 receptor antagonist protein-like. (294 aa)
	LOC105760863	Uncharacterized protein. (190 aa)
	CCL19	C-C motif chemokine ligand 19. (152 aa)
	ENSTGUP00000030391	Interleukin-8-like. (96 aa)
	C15orf39	Uncharacterized protein. (1020 aa)
	IL1R2	Interleukin 1 receptor type 2. (469 aa)
	IL17RE	Interleukin 17 receptor E. (678 aa)
	IL18BP	Interleukin-18-binding protein isoform X1. (200 aa)
	LOC100218724	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	IL6ST	Interleukin 6 signal transducer. (921 aa)
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	IL17D	Uncharacterized protein. (469 aa)
	IL21R	Interleukin 21 receptor. (593 aa)
	TYK2	Non-receptor tyrosine-protein kinase TYK2. (1175 aa)
	ACKR4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	LOC115496244	Tyrosine-protein kinase. (1148 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (199 aa)
	STAT4	Signal transducer and activator of transcription 4. (749 aa)
	ENSTGUP00000034101	annotation not available (743 aa)
	LOC100230358	Interferon alpha/beta receptor 1. (601 aa)
	CCL20	C-C motif chemokine. (150 aa)
	LOC105760310	Signal transducer and activator of transcription 2. (996 aa)
	CX3CL1	Uncharacterized protein. (429 aa)
	ENSTGUP00000034391	Mucin-2-like. (483 aa)
	CCR10	C-C chemokine receptor type 10. (350 aa)
	LOC101233427	C-X-C chemokine receptor type 2. (358 aa)
	CXCL8-2	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (184 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (194 aa)
	IFNGR2	Interferon gamma receptor 2 isoform X2. (340 aa)
	CNTFR	Ciliary neurotrophic factor receptor. (430 aa)
	ENSTGUP00000036648	Growth-regulated alpha protein-like. (103 aa)
	TRAF3IP2	SEFIR domain-containing protein. (560 aa)
	ACKR1	Atypical chemokine receptor 1. (317 aa)
	CCL17	C-C motif chemokine. (102 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (257 aa)
	LOC100221351	C-C motif chemokine 16. (127 aa)
	CXCL8-3	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (102 aa)
	IL11RA	Uncharacterized protein. (622 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR1	ACKR2	ENSTGUP00000037244	ENSTGUP00000000261	Atypical chemokine receptor 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.582
ACKR1	ACKR4	ENSTGUP00000037244	ENSTGUP00000032819	Atypical chemokine receptor 1.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.543
ACKR1	ENSTGUP00000036648	ENSTGUP00000037244	ENSTGUP00000036648	Atypical chemokine receptor 1.	Growth-regulated alpha protein-like.	0.546
ACKR1	LOC100222345	ENSTGUP00000037244	ENSTGUP00000001591	Atypical chemokine receptor 1.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.873
ACKR1	LOC100223328	ENSTGUP00000037244	ENSTGUP00000001587	Atypical chemokine receptor 1.	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family.	0.546
ACKR1	LOC115497720	ENSTGUP00000037244	ENSTGUP00000005163	Atypical chemokine receptor 1.	SCY domain-containing protein.	0.437
ACKR2	ACKR1	ENSTGUP00000000261	ENSTGUP00000037244	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Atypical chemokine receptor 1.	0.582
ACKR2	CCL19	ENSTGUP00000000261	ENSTGUP00000030305	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine ligand 19.	0.430
ACKR2	CCL20	ENSTGUP00000000261	ENSTGUP00000034163	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.438
ACKR2	CCR7	ENSTGUP00000000261	ENSTGUP00000002421	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.467
ACKR2	CXCL12	ENSTGUP00000000261	ENSTGUP00000018339	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Putative stromal cell derived factor 1; Belongs to the intercrine alpha (chemokine CxC) family.	0.612
ACKR2	LOC100218724	ENSTGUP00000000261	ENSTGUP00000031646	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.434
ACKR2	LOC100229516	ENSTGUP00000000261	ENSTGUP00000020008	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.728
ACKR2	LOC115497720	ENSTGUP00000000261	ENSTGUP00000005163	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	SCY domain-containing protein.	0.705
ACKR3	CCL19	ENSTGUP00000031951	ENSTGUP00000030305	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine ligand 19.	0.515
ACKR3	CCR5	ENSTGUP00000031951	ENSTGUP00000021568	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.457
ACKR3	CX3CL1	ENSTGUP00000031951	ENSTGUP00000034344	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.407
ACKR3	CXCL12	ENSTGUP00000031951	ENSTGUP00000018339	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Putative stromal cell derived factor 1; Belongs to the intercrine alpha (chemokine CxC) family.	0.996
ACKR3	CXCR4	ENSTGUP00000031951	ENSTGUP00000012180	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.915
ACKR3	ENSTGUP00000036648	ENSTGUP00000031951	ENSTGUP00000036648	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Growth-regulated alpha protein-like.	0.443