(67 nodes) Mixed, incl. Magnesium-dependent protein serine/threonine phosphatase complex, and Protein phosphatase 2A binding network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SIKE1	Suppressor of IKBKE 1. (203 aa)
	MASTL	Uncharacterized protein. (908 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	TRAF3IP3	TRAF3 interacting protein 3. (633 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	STRIP2	Striatin interacting protein 2. (487 aa)
	H0YVZ3_TAEGU	SMK-1 domain-containing protein. (621 aa)
	IGBP1	Uncharacterized protein. (341 aa)
	STK26	Protein kinase domain-containing protein. (417 aa)
	SGO1	Uncharacterized protein. (598 aa)
	PPP2R2A	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (481 aa)
	CACNG4	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (328 aa)
	H0Z3A6_TAEGU	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (402 aa)
	PPP2R5D	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (614 aa)
	PPP4R3B	SMK-1 domain-containing protein. (816 aa)
	PPP2R3A	Protein phosphatase 2 regulatory subunit B''alpha. (1132 aa)
	SLMAP	Sarcolemma associated protein. (844 aa)
	FNBP4	Formin binding protein 4. (962 aa)
	LOC100221841	AB hydrolase-1 domain-containing protein. (405 aa)
	LIPA	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (617 aa)
	STRN	Striatin. (678 aa)
	WDR64	Uncharacterized protein. (1057 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	LOC100223115	Protein phosphatase 2 regulatory subunit Bdelta. (455 aa)
	STRN3	WD_REPEATS_REGION domain-containing protein. (726 aa)
	PPP2R3C	EF-hand_13 domain-containing protein. (450 aa)
	PPP4R4	Uncharacterized protein. (843 aa)
	PPP2R5E	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (516 aa)
	PPME1	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. (359 aa)
	PPP2R1A	Uncharacterized protein. (587 aa)
	MAST1	Microtubule associated serine/threonine kinase 1. (1767 aa)
	STK25	Serine/threonine kinase 25. (436 aa)
	MAST2	Microtubule associated serine/threonine kinase 2. (2005 aa)
	PPP4R3A	Protein phosphatase 4 regulatory subunit 3A. (821 aa)
	PPP4R1	WRNPLPNID domain-containing protein. (1101 aa)
	PPP2R2C	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (502 aa)
	TIPRL	TOR signaling pathway regulator. (272 aa)
	ZCCHC2	Uncharacterized protein. (1185 aa)
	ENSTGUP00000021729	annotation not available (104 aa)
	MAST3	Microtubule associated serine/threonine kinase 3. (1496 aa)
	PPP6C	Serine/threonine-protein phosphatase. (389 aa)
	BPHL	AB hydrolase-1 domain-containing protein. (292 aa)
	CACNG5	Calcium voltage-gated channel auxiliary subunit gamma 5. (279 aa)
	CTTNBP2NL	CTTNBP2 N-terminal like. (945 aa)
	PPP2R2B	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
	ARPP19	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). (143 aa)
	PTPA	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (325 aa)
	STRIP1	Striatin interacting protein 1. (841 aa)
	PPP2R5A	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (477 aa)
	PPP4R2	Protein phosphatase 4 regulatory subunit 2. (406 aa)
	LOC100224270	Uncharacterized protein. (358 aa)
	PPP2R5C	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (577 aa)
	ZNF330	Zinc finger protein 330. (321 aa)
	ENSTGUP00000031635	annotation not available (347 aa)
	LOC115495876	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform. (556 aa)
	LOC100224823	WRNPLPNID domain-containing protein. (956 aa)
	FGFR1OP2	Uncharacterized protein. (269 aa)
	MAST4	Microtubule associated serine/threonine kinase family member 4. (2595 aa)
	ENSTGUP00000034045	annotation not available (411 aa)
	RELCH	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1206 aa)
	LCMT1	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (339 aa)
	PPEF1	Serine/threonine-protein phosphatase with EF-hands. (670 aa)
	ENSTGUP00000036425	Striatin-4-like. (1037 aa)
	ENSTGUP00000036878	annotation not available (134 aa)
	PPP4C	Protein phosphatase 4 catalytic subunit. (295 aa)
	GSC	Goosecoid homeobox. (441 aa)
	ENSA	Alpha-endosulfine isoform X1. (229 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARPP19	LOC100223115	ENSTGUP00000026693	ENSTGUP00000011993	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Protein phosphatase 2 regulatory subunit Bdelta.	0.524
ARPP19	LOC115495876	ENSTGUP00000026693	ENSTGUP00000032496	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform.	0.524
ARPP19	MAST1	ENSTGUP00000026693	ENSTGUP00000018942	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Microtubule associated serine/threonine kinase 1.	0.574
ARPP19	MAST2	ENSTGUP00000026693	ENSTGUP00000019788	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Microtubule associated serine/threonine kinase 2.	0.574
ARPP19	MAST3	ENSTGUP00000026693	ENSTGUP00000022943	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Microtubule associated serine/threonine kinase 3.	0.574
ARPP19	MAST4	ENSTGUP00000026693	ENSTGUP00000033650	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Microtubule associated serine/threonine kinase family member 4.	0.574
ARPP19	MASTL	ENSTGUP00000026693	ENSTGUP00000001157	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Uncharacterized protein.	0.880
ARPP19	PPP2CA	ENSTGUP00000026693	ENSTGUP00000001327	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Serine/threonine-protein phosphatase.	0.405
ARPP19	PPP2CB	ENSTGUP00000026693	ENSTGUP00000001817	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Serine/threonine-protein phosphatase.	0.405
ARPP19	PPP2R2A	ENSTGUP00000026693	ENSTGUP00000004382	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.667
ARPP19	PPP2R2B	ENSTGUP00000026693	ENSTGUP00000026255	cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.667
BPHL	PPP4R4	ENSTGUP00000024718	ENSTGUP00000013016	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.593
CACNG4	LOC100223115	ENSTGUP00000004516	ENSTGUP00000011993	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Protein phosphatase 2 regulatory subunit Bdelta.	0.682
CACNG4	PPP2CA	ENSTGUP00000004516	ENSTGUP00000001327	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Serine/threonine-protein phosphatase.	0.714
CACNG4	PPP2CB	ENSTGUP00000004516	ENSTGUP00000001817	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Serine/threonine-protein phosphatase.	0.714
CACNG4	PPP2R1A	ENSTGUP00000004516	ENSTGUP00000016633	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Uncharacterized protein.	0.650
CACNG4	PPP2R2A	ENSTGUP00000004516	ENSTGUP00000004382	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.671
CACNG4	PPP2R2B	ENSTGUP00000004516	ENSTGUP00000026255	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.671
CACNG4	PPP2R2C	ENSTGUP00000004516	ENSTGUP00000020357	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.682
CACNG4	PPP2R3A	ENSTGUP00000004516	ENSTGUP00000007306	Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	Protein phosphatase 2 regulatory subunit B''alpha.	0.651