(5 nodes) Negative regulation of TCF-dependent signaling by WNT ligand antagonists network (Taeniopygia guttata)

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Your Input:
	SOST	Sclerostin. (212 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1612 aa)
	DKK2	Dickkopf_N domain-containing protein. (269 aa)
	KREMEN1	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (390 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (263 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DKK1	DKK2	ENSTGUP00000029995	ENSTGUP00000024425	Dickkopf WNT signaling pathway inhibitor 1.	Dickkopf_N domain-containing protein.	0.601
DKK1	KREMEN1	ENSTGUP00000029995	ENSTGUP00000025843	Dickkopf WNT signaling pathway inhibitor 1.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.938
DKK1	LRP6	ENSTGUP00000029995	ENSTGUP00000013094	Dickkopf WNT signaling pathway inhibitor 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.982
DKK1	SOST	ENSTGUP00000029995	ENSTGUP00000003029	Dickkopf WNT signaling pathway inhibitor 1.	Sclerostin.	0.631
DKK2	DKK1	ENSTGUP00000024425	ENSTGUP00000029995	Dickkopf_N domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 1.	0.601
DKK2	KREMEN1	ENSTGUP00000024425	ENSTGUP00000025843	Dickkopf_N domain-containing protein.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.806
DKK2	LRP6	ENSTGUP00000024425	ENSTGUP00000013094	Dickkopf_N domain-containing protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.979
DKK2	SOST	ENSTGUP00000024425	ENSTGUP00000003029	Dickkopf_N domain-containing protein.	Sclerostin.	0.493
KREMEN1	DKK1	ENSTGUP00000025843	ENSTGUP00000029995	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf WNT signaling pathway inhibitor 1.	0.938
KREMEN1	DKK2	ENSTGUP00000025843	ENSTGUP00000024425	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Dickkopf_N domain-containing protein.	0.806
KREMEN1	LRP6	ENSTGUP00000025843	ENSTGUP00000013094	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.892
LRP6	DKK1	ENSTGUP00000013094	ENSTGUP00000029995	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf WNT signaling pathway inhibitor 1.	0.982
LRP6	DKK2	ENSTGUP00000013094	ENSTGUP00000024425	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Dickkopf_N domain-containing protein.	0.979
LRP6	KREMEN1	ENSTGUP00000013094	ENSTGUP00000025843	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.	0.892
LRP6	SOST	ENSTGUP00000013094	ENSTGUP00000003029	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Sclerostin.	0.998
SOST	DKK1	ENSTGUP00000003029	ENSTGUP00000029995	Sclerostin.	Dickkopf WNT signaling pathway inhibitor 1.	0.631
SOST	DKK2	ENSTGUP00000003029	ENSTGUP00000024425	Sclerostin.	Dickkopf_N domain-containing protein.	0.493
SOST	LRP6	ENSTGUP00000003029	ENSTGUP00000013094	Sclerostin.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.998