STRINGSTRING
FNTA FNTA SLC35D2 SLC35D2 DHDDS DHDDS PDSS1 PDSS1 COQ2 COQ2 COQ4 COQ4 COQ8A COQ8A COQ9 COQ9 HMGCR HMGCR MVK MVK LOC100223864 LOC100223864 ITPRIPL2 ITPRIPL2 COQ5 COQ5 COQ10B COQ10B ADCK2 ADCK2 NUS1 NUS1 COQ6 COQ6 PDSS2 PDSS2 COQ3 COQ3 ADCK1 ADCK1 FDPS FDPS HMGCS2 HMGCS2 IDI1 IDI1 FBXO30 FBXO30 ZMPSTE24 ZMPSTE24 ITPRIP ITPRIP GGPS1 GGPS1 H1A298_TAEGU H1A298_TAEGU PGGT1B PGGT1B ICMT ICMT ENSTGUP00000029073 ENSTGUP00000029073 LOC115492109 LOC115492109 CHURC1 CHURC1 COQ7 COQ7 ACOT13 ACOT13 PMVK PMVK COQ10A COQ10A ENSTGUP00000035357 ENSTGUP00000035357 RUSC1 RUSC1 UBIAD1 UBIAD1 ENSTGUP00000038471 ENSTGUP00000038471
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FNTAFarnesyltransferase, CAAX box, alpha. (368 aa)
SLC35D2TPT domain-containing protein. (335 aa)
DHDDSAlkyl transferase; Belongs to the UPP synthase family. (333 aa)
PDSS1Decaprenyl diphosphate synthase subunit 1; Belongs to the FPP/GGPP synthase family. (382 aa)
COQ24-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (347 aa)
COQ4Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (387 aa)
COQ8ACoenzyme Q8A. (650 aa)
COQ9Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (314 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (1030 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
LOC100223864Uncharacterized protein. (409 aa)
ITPRIPL2ITPRIP like 2. (485 aa)
COQ52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (312 aa)
COQ10BPolyketide_cyc domain-containing protein. (221 aa)
ADCK2AarF domain containing kinase 2. (615 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (282 aa)
COQ6Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (464 aa)
PDSS2Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (389 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (346 aa)
ADCK1AarF domain containing kinase 1. (520 aa)
FDPSFarnesyl diphosphate synthase. (345 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (507 aa)
IDI1Nudix hydrolase domain-containing protein. (266 aa)
FBXO30F-box protein 30. (757 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (469 aa)
ITPRIPInositol 1,4,5-trisphosphate receptor interacting protein. (549 aa)
GGPS1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (434 aa)
H1A298_TAEGUUncharacterized protein. (362 aa)
PGGT1BProtein geranylgeranyltransferase type I subunit beta. (245 aa)
ICMTProtein-S-isoprenylcysteine O-methyltransferase. (466 aa)
ENSTGUP00000029073annotation not available (204 aa)
LOC115492109Prenyl protein peptidase. (314 aa)
CHURC1Churchill domain containing 1. (112 aa)
COQ75-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (201 aa)
ACOT134HBT domain-containing protein. (387 aa)
PMVKPhosphomevalonate kinase. (205 aa)
COQ10ACoenzyme Q-binding protein COQ10 homolog A, mitochondrial. (204 aa)
ENSTGUP00000035357annotation not available (690 aa)
RUSC1RUN and SH3 domain containing 1. (1209 aa)
UBIAD1UbiA prenyltransferase domain containing 1. (338 aa)
ENSTGUP00000038471annotation not available (109 aa)
Your Current Organism:
Taeniopygia guttata
NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch
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