(22 nodes) Endothelial cell proliferation network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	XBP1	X-box binding protein 1. (260 aa)
	TEK	TEK receptor tyrosine kinase. (1117 aa)
	EPHA2	EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (505 aa)
	BMPER	BMP binding endothelial regulator. (679 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (501 aa)
	PRKX	Uncharacterized protein; Belongs to the protein kinase superfamily. (364 aa)
	LOXL3	Lysyl oxidase like 3. (772 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1036 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	PIK3CB	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	VSTM4	V-set and transmembrane domain containing 4. (323 aa)
	APOA1	Uncharacterized protein. (264 aa)
	ENSTGUP00000022569	annotation not available (715 aa)
	ENSTGUP00000024315	annotation not available (176 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (117 aa)
	ENSTGUP00000034802	annotation not available (694 aa)
	PROK2	Prokineticin 2. (116 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA1	SCARB1	ENSTGUP00000022325	ENSTGUP00000005161	Uncharacterized protein.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.875
BMPER	BMPR2	ENSTGUP00000005485	ENSTGUP00000010438	BMP binding endothelial regulator.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.468
BMPR2	BMPER	ENSTGUP00000010438	ENSTGUP00000005485	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	BMP binding endothelial regulator.	0.468
BMPR2	TGFBR1	ENSTGUP00000010438	ENSTGUP00000006937	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.611
CAV1	CAV2	ENSTGUP00000027745	ENSTGUP00000030045	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.997
CAV1	CAV3	ENSTGUP00000027745	ENSTGUP00000010724	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
CAV2	CAV1	ENSTGUP00000030045	ENSTGUP00000027745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.997
CAV2	CAV3	ENSTGUP00000030045	ENSTGUP00000010724	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
CAV3	CAV1	ENSTGUP00000010724	ENSTGUP00000027745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
CAV3	CAV2	ENSTGUP00000010724	ENSTGUP00000030045	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
CAV3	SCARB1	ENSTGUP00000010724	ENSTGUP00000005161	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.587
CAV3	TGFBR1	ENSTGUP00000010724	ENSTGUP00000006937	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.577
ENSTGUP00000024315	SCARB1	ENSTGUP00000024315	ENSTGUP00000005161	annotation not available	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.400
EPHA2	FGF7	ENSTGUP00000002121	ENSTGUP00000019495	EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.663
EPHA2	SCARB1	ENSTGUP00000002121	ENSTGUP00000005161	EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.400
FGF7	EPHA2	ENSTGUP00000019495	ENSTGUP00000002121	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.663
FGF7	PIK3CB	ENSTGUP00000019495	ENSTGUP00000021600	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.497
FGF7	TEK	ENSTGUP00000019495	ENSTGUP00000001438	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	TEK receptor tyrosine kinase.	0.769
PIK3CB	FGF7	ENSTGUP00000021600	ENSTGUP00000019495	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.497
PIK3CB	TEK	ENSTGUP00000021600	ENSTGUP00000001438	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	TEK receptor tyrosine kinase.	0.617