(123 nodes) Ras protein signal transduction network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KPNB1	Karyopherin subunit beta 1. (876 aa)
	H0YPP1_TAEGU	BZIP domain-containing protein. (381 aa)
	DOK3	IRS-type PTB domain-containing protein. (428 aa)
	MYO9B	Myosin IXB. (2044 aa)
	ENSTGUP00000000650	annotation not available (226 aa)
	PHACTR4	Phosphatase and actin regulator. (712 aa)
	WASF2	WASP family member 2. (500 aa)
	CSDE1	Cold shock domain containing E1. (796 aa)
	NRAS	NRAS proto-oncogene, GTPase. (280 aa)
	RAP1A	Uncharacterized protein. (184 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (406 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1322 aa)
	RASGEF1B	RasGEF domain family member 1B. (491 aa)
	ARHGDIA	Rho GDP dissociation inhibitor alpha. (272 aa)
	RACGAP1	Rac GTPase activating protein 1. (630 aa)
	GPSM2	G protein signaling modulator 2. (662 aa)
	RASSF1	Ras association domain family member 1. (324 aa)
	MRAS	Muscle RAS oncogene homolog. (347 aa)
	NTN1	Netrin 1. (606 aa)
	RAB33A	RAB33A, member RAS oncogene family. (228 aa)
	RIPOR1	Uncharacterized protein. (1057 aa)
	PPP1R21	Protein phosphatase 1 regulatory subunit 21. (776 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1044 aa)
	BRAP	Uncharacterized protein. (591 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (471 aa)
	C15orf62	Chromosome 15 open reading frame 62. (265 aa)
	LOC100226244	Uncharacterized protein. (191 aa)
	EPS8L2	EPS8 like 2. (736 aa)
	RAB21	RAB21, member RAS oncogene family. (220 aa)
	USP50	USP domain-containing protein; Belongs to the peptidase C19 family. (340 aa)
	PLEKHG7	Uncharacterized protein. (376 aa)
	RRAS2	RAS related 2. (203 aa)
	CTNNAL1	Catenin alpha like 1. (763 aa)
	KSR1	Kinase suppressor of ras 1. (900 aa)
	RASGRP3	RAS guanyl releasing protein 3. (692 aa)
	ERP27	Endoplasmic reticulum protein 27. (403 aa)
	BCL6	BCL6 transcription repressor. (729 aa)
	KIAA0355	KIAA0355. (1053 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (314 aa)
	HRAS	Putative v-Ha-ras Harvey sarcoma viral oncogene variant 2. (189 aa)
	RAB12	RAB12, member RAS oncogene family. (386 aa)
	ROCK1	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1358 aa)
	RHOV	Uncharacterized protein. (231 aa)
	RB1	RB transcriptional corepressor 1. (931 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1483 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1331 aa)
	ENSTGUP00000017345	annotation not available (744 aa)
	NKIRAS2	NFKB inhibitor interacting Ras like 2. (191 aa)
	GNA12	G protein subunit alpha 12. (385 aa)
	CNKSR1	Uncharacterized protein. (803 aa)
	ENSTGUP00000019468	annotation not available (572 aa)
	RAPGEF1	Uncharacterized protein. (1232 aa)
	RAP2C	RAP2C, member of RAS oncogene family. (505 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1505 aa)
	RHOU	Ras homolog family member U. (279 aa)
	RASGRF1	Ras protein specific guanine nucleotide releasing factor 1. (1229 aa)
	RAB4A	RAB4A, member RAS oncogene family. (248 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor-like 1. (626 aa)
	RAP1A-2	Ras-related protein Rap-1A. (184 aa)
	ENSTGUP00000021025	annotation not available (174 aa)
	ENSTGUP00000021519	annotation not available (333 aa)
	DOK1	Docking protein 1. (683 aa)
	ENSTGUP00000022514	annotation not available (422 aa)
	ENSTGUP00000022601	annotation not available (168 aa)
	LOC100225382	Uncharacterized protein. (1621 aa)
	DOK2	Docking protein 2. (457 aa)
	CDC42EP1	CDC42 effector protein 1. (412 aa)
	RABGEF1	Uncharacterized protein. (538 aa)
	RAB9A	RAB9A, member RAS oncogene family. (201 aa)
	RASGRP1	RAS guanyl releasing protein 1. (792 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	SGSM3	Small G protein signaling modulator 3. (753 aa)
	RALA	Putative Ras family small GTP binding protein RALA. (206 aa)
	RASGRF2	Uncharacterized protein. (1247 aa)
	ENSTGUP00000027548	annotation not available (629 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1026 aa)
	DBNL	Drebrin-like protein. (460 aa)
	ENSTGUP00000028333	annotation not available (390 aa)
	LOC115491504	Cyclic nucleotide-binding domain-containing protein. (932 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1804 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (162 aa)
	RAB35	RAB35, member RAS oncogene family. (376 aa)
	H0YQU3_TAEGU	Rho-GAP domain-containing protein. (480 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (836 aa)
	RALB	RAS like proto-oncogene B. (273 aa)
	SHTN1	Shootin 1. (682 aa)
	RAB33B	RAB33B, member RAS oncogene family. (228 aa)
	RIT1	Ras like without CAAX 1. (215 aa)
	USP8	Uncharacterized protein; Belongs to the peptidase C19 family. (1115 aa)
	RIT2	Ras like without CAAX 2. (217 aa)
	WASF1	WASP family member 1. (610 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	RAP2B	Ras-related protein Rap-2B. (183 aa)
	DNMT1	DNA methyltransferase 1. (1503 aa)
	RAB39A	Ras-related protein Rab-39A. (249 aa)
	ENSTGUP00000032655	annotation not available (422 aa)
	BRK1	Chromosome 3 open reading frame 10. (176 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (866 aa)
	KSR2	Kinase suppressor of ras 2. (972 aa)
	RERG	Uncharacterized protein. (199 aa)
	ENSTGUP00000033523	annotation not available (393 aa)
	RAB30	RAB30, member RAS oncogene family. (203 aa)
	SETDB1	SET domain bifurcated histone lysine methyltransferase 1. (1303 aa)
	ENSTGUP00000033742	annotation not available (1045 aa)
	RAB39B	RAB39B, member RAS oncogene family. (213 aa)
	ARHGDIG	Rho GDP-dissociation inhibitor 3. (320 aa)
	CDC42EP3	CDC42 effector protein 3. (255 aa)
	USP28	Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1135 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	TAX1BP3	Tax1 binding protein 3. (139 aa)
	TMEM19	Transmembrane protein 19. (443 aa)
	CDC42	Cell division cycle 42. (302 aa)
	NGFR	Tumor necrosis factor receptor superfamily member 16. (475 aa)
	RHOH	Ras homolog family member H. (191 aa)
	EPS8L3	EPS8 like 3. (521 aa)
	LOC105759334	PDZ domain-containing protein. (188 aa)
	KRAS	GTPase KRas. (217 aa)
	RFXANK	Uncharacterized protein. (546 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1292 aa)
	RASGEF1A	Uncharacterized protein. (527 aa)
	PLCE1	Phosphoinositide phospholipase C. (2331 aa)
	CDC42EP4	CDC42 effector protein 4. (317 aa)
	ADGRG1	G_PROTEIN_RECEP_F2_4 domain-containing protein. (852 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRG1	GNA12	ENSTGUP00000038415	ENSTGUP00000018487	G_PROTEIN_RECEP_F2_4 domain-containing protein.	G protein subunit alpha 12.	0.748
ADGRG1	GNA13	ENSTGUP00000038415	ENSTGUP00000026421	G_PROTEIN_RECEP_F2_4 domain-containing protein.	G protein subunit alpha 13.	0.734
AGTR1	GNA12	ENSTGUP00000034966	ENSTGUP00000018487	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 12.	0.925
AGTR1	GNA13	ENSTGUP00000034966	ENSTGUP00000026421	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 13.	0.921
ARHGAP5	CDC42	ENSTGUP00000020218	ENSTGUP00000036310	Rho GTPase activating protein 5.	Cell division cycle 42.	0.485
ARHGAP5	LOC100225382	ENSTGUP00000020218	ENSTGUP00000023753	Rho GTPase activating protein 5.	Uncharacterized protein.	0.902
ARHGAP5	LOC100226244	ENSTGUP00000020218	ENSTGUP00000007228	Rho GTPase activating protein 5.	Uncharacterized protein.	0.432
ARHGDIA	CDC42	ENSTGUP00000003610	ENSTGUP00000036310	Rho GDP dissociation inhibitor alpha.	Cell division cycle 42.	0.862
ARHGDIA	LOC100226244	ENSTGUP00000003610	ENSTGUP00000007228	Rho GDP dissociation inhibitor alpha.	Uncharacterized protein.	0.763
ARHGDIA	NGFR	ENSTGUP00000003610	ENSTGUP00000036482	Rho GDP dissociation inhibitor alpha.	Tumor necrosis factor receptor superfamily member 16.	0.805
ARHGDIA	RHOH	ENSTGUP00000003610	ENSTGUP00000036957	Rho GDP dissociation inhibitor alpha.	Ras homolog family member H.	0.802
ARHGDIA	RHOU	ENSTGUP00000003610	ENSTGUP00000020328	Rho GDP dissociation inhibitor alpha.	Ras homolog family member U.	0.660
ARHGDIA	RHOV	ENSTGUP00000003610	ENSTGUP00000011103	Rho GDP dissociation inhibitor alpha.	Uncharacterized protein.	0.660
ARHGDIG	CDC42	ENSTGUP00000034116	ENSTGUP00000036310	Rho GDP-dissociation inhibitor 3.	Cell division cycle 42.	0.862
ARHGDIG	LOC100226244	ENSTGUP00000034116	ENSTGUP00000007228	Rho GDP-dissociation inhibitor 3.	Uncharacterized protein.	0.763
ARHGDIG	NGFR	ENSTGUP00000034116	ENSTGUP00000036482	Rho GDP-dissociation inhibitor 3.	Tumor necrosis factor receptor superfamily member 16.	0.805
ARHGDIG	RHOH	ENSTGUP00000034116	ENSTGUP00000036957	Rho GDP-dissociation inhibitor 3.	Ras homolog family member H.	0.802
ARHGDIG	RHOU	ENSTGUP00000034116	ENSTGUP00000020328	Rho GDP-dissociation inhibitor 3.	Ras homolog family member U.	0.660
ARHGDIG	RHOV	ENSTGUP00000034116	ENSTGUP00000011103	Rho GDP-dissociation inhibitor 3.	Uncharacterized protein.	0.660
BCL6	ENSTGUP00000021519	ENSTGUP00000009713	ENSTGUP00000021519	BCL6 transcription repressor.	annotation not available	0.483