(13 nodes) Multicellular organism aging network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RNF165	Ring finger protein 165. (153 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (543 aa)
	WRN	WRN RecQ like helicase. (1449 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	ADRA1A	Adrenoceptor alpha 1A. (464 aa)
	EDN1	Endothelin 1. (202 aa)
	HELT	Helt bHLH transcription factor. (240 aa)
	SEC63	SEC63 homolog, protein translocation regulator. (755 aa)
	GNA12	G protein subunit alpha 12. (385 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (702 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme. (518 aa)
	SLC1A2	Amino acid transporter. (578 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1A	EDN1	ENSTGUP00000004282	ENSTGUP00000005994	Adrenoceptor alpha 1A.	Endothelin 1.	0.646
ADRA1A	GNA12	ENSTGUP00000004282	ENSTGUP00000018487	Adrenoceptor alpha 1A.	G protein subunit alpha 12.	0.962
ADRA1A	GNA13	ENSTGUP00000004282	ENSTGUP00000026421	Adrenoceptor alpha 1A.	G protein subunit alpha 13.	0.962
EDN1	ADRA1A	ENSTGUP00000005994	ENSTGUP00000004282	Endothelin 1.	Adrenoceptor alpha 1A.	0.646
EDN1	EDNRA	ENSTGUP00000005994	ENSTGUP00000002706	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDNRA	EDN1	ENSTGUP00000002706	ENSTGUP00000005994	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.999
EDNRA	GNA12	ENSTGUP00000002706	ENSTGUP00000018487	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 12.	0.945
EDNRA	GNA13	ENSTGUP00000002706	ENSTGUP00000026421	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 13.	0.931
ERCC1	WRN	ENSTGUP00000036547	ENSTGUP00000001824	ERCC excision repair 1, endonuclease non-catalytic subunit.	WRN RecQ like helicase.	0.809
GNA12	ADRA1A	ENSTGUP00000018487	ENSTGUP00000004282	G protein subunit alpha 12.	Adrenoceptor alpha 1A.	0.962
GNA12	EDNRA	ENSTGUP00000018487	ENSTGUP00000002706	G protein subunit alpha 12.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.945
GNA12	GNA13	ENSTGUP00000018487	ENSTGUP00000026421	G protein subunit alpha 12.	G protein subunit alpha 13.	0.982
GNA13	ADRA1A	ENSTGUP00000026421	ENSTGUP00000004282	G protein subunit alpha 13.	Adrenoceptor alpha 1A.	0.962
GNA13	EDNRA	ENSTGUP00000026421	ENSTGUP00000002706	G protein subunit alpha 13.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.931
GNA13	GNA12	ENSTGUP00000026421	ENSTGUP00000018487	G protein subunit alpha 13.	G protein subunit alpha 12.	0.982
TP63	WRN	ENSTGUP00000022691	ENSTGUP00000001824	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	WRN RecQ like helicase.	0.723
WRN	ERCC1	ENSTGUP00000001824	ENSTGUP00000036547	WRN RecQ like helicase.	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.809
WRN	TP63	ENSTGUP00000001824	ENSTGUP00000022691	WRN RecQ like helicase.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.723