(59 nodes) Regulation of cellular ketone metabolic process network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NCOR2	Nuclear receptor corepressor 2. (2480 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (473 aa)
	H6PD	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (790 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (337 aa)
	SIRT1	Sirtuin 1. (750 aa)
	ABCD2	ATP binding cassette subfamily D member 2. (734 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (299 aa)
	SOX9	SRY-box transcription factor 9. (474 aa)
	BRCA1	Uncharacterized protein. (1803 aa)
	DAB2	DAB adaptor protein 2. (716 aa)
	PDK4	Protein-serine/threonine kinase. (419 aa)
	SLC7A11	Solute carrier family 7 member 11. (503 aa)
	DGKQ	Diacylglycerol kinase. (938 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (720 aa)
	ATCAY	ATCAY kinesin light chain interacting caytaxin. (440 aa)
	STARD4	StAR related lipid transfer domain containing 4. (216 aa)
	EGR1	Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (245 aa)
	CD74	Uncharacterized protein. (289 aa)
	FGFR4	Fibroblast growth factor receptor. (865 aa)
	BMP6	Bone morphogenetic protein 6. (414 aa)
	LPGAT1	Lysophosphatidylglycerol acyltransferase 1. (370 aa)
	PRMT3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (530 aa)
	H0ZQ02_TAEGU	Uncharacterized protein. (480 aa)
	COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (346 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	ETFBKMT	Uncharacterized protein. (271 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
	APPL2	Uncharacterized protein. (658 aa)
	NR1H3	Uncharacterized protein. (418 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	PDK1	Protein-serine/threonine kinase. (408 aa)
	FH	Fumarate hydratase. (509 aa)
	PDK3	Protein-serine/threonine kinase. (406 aa)
	NCOR1	Nuclear receptor corepressor 1. (2533 aa)
	PPTC7	Protein phosphatase; Belongs to the PP2C family. (297 aa)
	SIRT5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (310 aa)
	ERLIN2	ER lipid raft associated 2. (444 aa)
	ANXA1	Annexin. (364 aa)
	SLC45A3	Solute carrier family 45 member 3. (572 aa)
	ERLIN1	PHB domain-containing protein. (347 aa)
	FABP5	Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (185 aa)
	MLYCD	Malonyl-CoA decarboxylase. (544 aa)
	WDTC1	WD and tetratricopeptide repeats 1. (827 aa)
	PIBF1	Progesterone immunomodulatory binding factor 1. (793 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (553 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1338 aa)
	ENSTGUP00000028883	annotation not available (59 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	TYSND1	Peroxisomal leader peptide-processing protease. (516 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
	REST	RE1 silencing transcription factor. (893 aa)
	PPARD	Uncharacterized protein. (449 aa)
	APOA1	Uncharacterized protein. (264 aa)
	SCAP	Sterol regulatory element-binding protein cleavage-activating protein isoform X1. (1283 aa)
	APOA4	Apolipoprotein A-IV isoform X1. (367 aa)
	SIRT4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (315 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (473 aa)
	LONP2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-. (851 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL2	ENSTGUP00000020549	ENSTGUP00000011422	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.677
ADIPOQ	IL1B	ENSTGUP00000020549	ENSTGUP00000003479	Adiponectin, C1Q and collagen domain containing.	Interleukin-1; Belongs to the IL-1 family.	0.493
ADIPOQ	PPARA	ENSTGUP00000020549	ENSTGUP00000012160	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator activated receptor alpha.	0.688
ADIPOQ	PPARG	ENSTGUP00000020549	ENSTGUP00000004204	Adiponectin, C1Q and collagen domain containing.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.628
ADIPOQ	SIRT1	ENSTGUP00000020549	ENSTGUP00000003586	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.523
ANXA1	CAV1	ENSTGUP00000038342	ENSTGUP00000027745	Annexin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
APOA1	APOA4	ENSTGUP00000022325	ENSTGUP00000025748	Uncharacterized protein.	Apolipoprotein A-IV isoform X1.	0.808
APOA1	PPARG	ENSTGUP00000022325	ENSTGUP00000004204	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.641
APOA4	APOA1	ENSTGUP00000025748	ENSTGUP00000022325	Apolipoprotein A-IV isoform X1.	Uncharacterized protein.	0.808
APPL2	ADIPOQ	ENSTGUP00000011422	ENSTGUP00000020549	Uncharacterized protein.	Adiponectin, C1Q and collagen domain containing.	0.677
BRCA1	IL1B	ENSTGUP00000002955	ENSTGUP00000003479	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.491
CAV1	ANXA1	ENSTGUP00000027745	ENSTGUP00000038342	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Annexin.	0.460
CAV1	CAV3	ENSTGUP00000027745	ENSTGUP00000010724	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
CAV1	PPARG	ENSTGUP00000027745	ENSTGUP00000004204	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.686
CAV3	CAV1	ENSTGUP00000010724	ENSTGUP00000027745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.963
CYP7A1	FGF19	ENSTGUP00000011472	ENSTGUP00000025874	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.597
CYP7A1	FGFR4	ENSTGUP00000011472	ENSTGUP00000019742	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Fibroblast growth factor receptor.	0.435
CYP7A1	NR1H3	ENSTGUP00000011472	ENSTGUP00000010811	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.459
CYP7A1	NR1H4	ENSTGUP00000011472	ENSTGUP00000009262	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Nuclear receptor subfamily 1 group H member 4.	0.713
CYP7A1	PPARA	ENSTGUP00000011472	ENSTGUP00000012160	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Peroxisome proliferator activated receptor alpha.	0.456