(26 nodes) Regulation of cardiac muscle hypertrophy network (Taeniopygia guttata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERRFI1	ERBB receptor feedback inhibitor 1. (463 aa)
	ENSTGUP00000036048	annotation not available (549 aa)
	SMAD4	SMAD family member 4. (514 aa)
	LMCD1	LIM and cysteine rich domains 1. (432 aa)
	LOC115492063	Glucose-6-phosphate 1-dehydrogenase. (540 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1338 aa)
	GLRX3	Taeniopygia guttata thioredoxin-like 2-like (LOC100190035), mRNA. (588 aa)
	TRIM63	Tripartite motif containing 63. (447 aa)
	ENSTGUP00000020434	annotation not available (505 aa)
	MTPN	Myotrophin. (286 aa)
	MEF2A	Myocyte enhancer factor 2A. (496 aa)
	AKAP6	A-kinase anchoring protein 6. (2302 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (400 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (584 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	TNFRSF1A	Uncharacterized protein. (429 aa)
	MLIP	Muscular LMNA interacting protein. (878 aa)
	ROCK1	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1358 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (1035 aa)
	EDN1	Endothelin 1. (202 aa)
	PDE9A	Phosphodiesterase. (518 aa)
	ADRA1A	Adrenoceptor alpha 1A. (464 aa)
	TNFRSF1B	Uncharacterized protein. (457 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (803 aa)
	ENSTGUP00000000958	Proteoglycan 4 isoform X1. (850 aa)
	H0YRP7_TAEGU	SCP domain-containing protein; Belongs to the CRISP family. (138 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1A	EDN1	ENSTGUP00000004282	ENSTGUP00000005994	Adrenoceptor alpha 1A.	Endothelin 1.	0.646
EDN1	ADRA1A	ENSTGUP00000005994	ENSTGUP00000004282	Endothelin 1.	Adrenoceptor alpha 1A.	0.646
ROCK1	SLC9A1	ENSTGUP00000010612	ENSTGUP00000000997	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	0.923
SLC9A1	ROCK1	ENSTGUP00000000997	ENSTGUP00000010612	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.923
TNFRSF1A	TNFRSF1B	ENSTGUP00000013762	ENSTGUP00000002540	Uncharacterized protein.	Uncharacterized protein.	0.691
TNFRSF1B	TNFRSF1A	ENSTGUP00000002540	ENSTGUP00000013762	Uncharacterized protein.	Uncharacterized protein.	0.691