(34 nodes) Positive regulation of phosphatidylinositol 3-kinase signaling network (Taeniopygia guttata)

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Predicted Interactions

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Your Input:
	MYDGF	Myeloid derived growth factor. (298 aa)
	TEK	TEK receptor tyrosine kinase. (1117 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (775 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
	SOX9	SRY-box transcription factor 9. (474 aa)
	SIRT1	Sirtuin 1. (750 aa)
	NCF1	Neutrophil cytosolic factor 1. (386 aa)
	HAX1	Uncharacterized protein. (275 aa)
	UNC5B	Uncharacterized protein. (953 aa)
	PDGFC	Platelet derived growth factor C. (345 aa)
	FSHR	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (693 aa)
	ROR1-2	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (462 aa)
	PRR5L	Proline rich 5 like. (349 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (880 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (608 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (278 aa)
	NTRK2	Tyrosine-protein kinase receptor. (842 aa)
	PPARD	Uncharacterized protein. (449 aa)
	NTRK3	Tyrosine-protein kinase receptor. (852 aa)
	PRR5	Proline rich 5. (413 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	IGF1	Insulin like growth factor 1. (153 aa)
	LEP	Taeniopygia guttata leptin (LEP), mRNA. (168 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1340 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (938 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (433 aa)
	ENSTGUP00000031473	annotation not available (499 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (840 aa)
	ROR1	Inactive tyrosine-protein kinase transmembrane receptor ROR1-like. (940 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (547 aa)
	PIK3AP1	Phosphoinositide-3-kinase adaptor protein 1. (804 aa)
	MYOC	Myocilin. (521 aa)
	LOC100229618	Alpha-1-antiproteinase-like isoform X1. (445 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	F2	ENSTGUP00000010275	ENSTGUP00000010918	Angiotensinogen; Belongs to the serpin family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.680
AGT	LEP	ENSTGUP00000010275	ENSTGUP00000028222	Angiotensinogen; Belongs to the serpin family.	Taeniopygia guttata leptin (LEP), mRNA.	0.422
F2	AGT	ENSTGUP00000010918	ENSTGUP00000010275	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Angiotensinogen; Belongs to the serpin family.	0.680
F2	LOC100229618	ENSTGUP00000010918	ENSTGUP00000038285	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Alpha-1-antiproteinase-like isoform X1.	0.572
FSHR	SOX9	ENSTGUP00000005884	ENSTGUP00000002966	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.	SRY-box transcription factor 9.	0.715
HGF	IGF1	ENSTGUP00000002672	ENSTGUP00000026866	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Insulin like growth factor 1.	0.903
HGF	KDR	ENSTGUP00000002672	ENSTGUP00000029011	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.807
HGF	NTRK2	ENSTGUP00000002672	ENSTGUP00000021181	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Tyrosine-protein kinase receptor.	0.718
HGF	NTRK3	ENSTGUP00000002672	ENSTGUP00000024066	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Tyrosine-protein kinase receptor.	0.544
HGF	PDGFB	ENSTGUP00000002672	ENSTGUP00000020140	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.913
HGF	PDGFC	ENSTGUP00000002672	ENSTGUP00000005603	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Platelet derived growth factor C.	0.915
HGF	TEK	ENSTGUP00000002672	ENSTGUP00000001438	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	TEK receptor tyrosine kinase.	0.756
IGF1	HGF	ENSTGUP00000026866	ENSTGUP00000002672	Insulin like growth factor 1.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.903
IGF1	KDR	ENSTGUP00000026866	ENSTGUP00000029011	Insulin like growth factor 1.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.650
IGF1	NTRK2	ENSTGUP00000026866	ENSTGUP00000021181	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.665
IGF1	PDGFB	ENSTGUP00000026866	ENSTGUP00000020140	Insulin like growth factor 1.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.900
IGF1	PDGFC	ENSTGUP00000026866	ENSTGUP00000005603	Insulin like growth factor 1.	Platelet derived growth factor C.	0.900
IGF1	TEK	ENSTGUP00000026866	ENSTGUP00000001438	Insulin like growth factor 1.	TEK receptor tyrosine kinase.	0.650
KDR	HGF	ENSTGUP00000029011	ENSTGUP00000002672	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.807
KDR	IGF1	ENSTGUP00000029011	ENSTGUP00000026866	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Insulin like growth factor 1.	0.650