(119 nodes) Protein processing network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PARL	Rhomboid domain-containing protein. (236 aa)
	F3	Coagulation factor III, tissue factor. (402 aa)
	SPCS1	Putative signal peptidase 12 kDa. (174 aa)
	CPE	Carboxypeptidase E. (436 aa)
	TLL1	Metalloendopeptidase. (1044 aa)
	ADAM10	ADAM metallopeptidase domain 10. (911 aa)
	NCSTN	Nicastrin. (879 aa)
	BACE2	Beta-secretase 2; Belongs to the peptidase A1 family. (521 aa)
	TMEM208	Uncharacterized protein. (173 aa)
	ADAM19	ADAM metallopeptidase domain 19. (891 aa)
	CYFIP2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (425 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (905 aa)
	PCSK4	Proprotein convertase subtilisin/kexin type 4. (707 aa)
	PITRM1	M16C_associated domain-containing protein. (1030 aa)
	LOC100218918	Uncharacterized protein; Belongs to the peptidase C1 family. (546 aa)
	YME1L1	YME1 like 1 ATPase. (845 aa)
	STOML2	Stomatin like 2. (334 aa)
	PRSS12	Serine protease 12; Belongs to the peptidase S1 family. (817 aa)
	H0YUG4_TAEGU	Uncharacterized protein. (307 aa)
	ACE	Angiotensin-converting enzyme. (1277 aa)
	F9	Coagulation factor IX. (467 aa)
	DISP1	Dispatched RND transporter family member 1. (1593 aa)
	MMEL1	Uncharacterized protein. (773 aa)
	METAP1	Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). (387 aa)
	SRGN	Uncharacterized protein. (140 aa)
	CASP6	Uncharacterized protein; Belongs to the peptidase C14A family. (303 aa)
	VSIR	Ig-like domain-containing protein. (310 aa)
	APOH	Uncharacterized protein. (350 aa)
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (458 aa)
	FGG	Fibrinogen gamma chain. (433 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (749 aa)
	GLG1	Golgi glycoprotein 1. (1139 aa)
	SPCS3	Signal peptidase complex subunit 3. (180 aa)
	CPD	Uncharacterized protein. (1368 aa)
	HM13	Histocompatibility minor 13. (393 aa)
	MBTPS1	Membrane bound transcription factor peptidase, site 1. (1061 aa)
	LOC115496886	Protein kinase domain-containing protein. (554 aa)
	CPM	Carboxypeptidase M. (361 aa)
	LOC100229828	Uncharacterized protein; Belongs to the peptidase S1 family. (822 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1035 aa)
	MYRFL	Myelin regulatory factor like. (264 aa)
	TLL2	Metalloendopeptidase. (1010 aa)
	SPG7	SPG7 matrix AAA peptidase subunit, paraplegin. (815 aa)
	CORIN	Uncharacterized protein. (1130 aa)
	VEZT	Vezatin, adherens junctions transmembrane protein. (810 aa)
	METAP2	Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily. (481 aa)
	LONP2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-. (851 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
	PCSK6	Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (926 aa)
	CPN1	Carboxypeptidase N subunit 1. (453 aa)
	DHCR24	24-dehydrocholesterol reductase. (525 aa)
	PCSK9	Peptidase_S8 domain-containing protein; Belongs to the peptidase S8 family. (663 aa)
	OMA1	OMA1 zinc metallopeptidase. (531 aa)
	SPPL3	Signal peptide peptidase like 3. (384 aa)
	PIDD1	P53-induced death domain protein 1. (894 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (367 aa)
	XPNPEP3	AMP_N domain-containing protein. (507 aa)
	SPRTN	SprT-like N-terminal domain. (493 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme. (789 aa)
	ECE2	Uncharacterized protein. (769 aa)
	LOC100223333	Caspase 8. (459 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (475 aa)
	CPZ	FZ domain-containing protein. (649 aa)
	HGFAC	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (586 aa)
	CASP7	Uncharacterized protein; Belongs to the peptidase C14A family. (309 aa)
	SCG5	Secretogranin V. (250 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (553 aa)
	DYNC2H1	Dynein cytoplasmic 2 heavy chain 1. (4302 aa)
	ADAM17	ADAM metallopeptidase domain 17. (918 aa)
	KEL	Uncharacterized protein. (718 aa)
	CASP2	Uncharacterized protein; Belongs to the peptidase C14A family. (426 aa)
	MEP1A	Meprin A subunit. (609 aa)
	C1R	Complement C1r; Belongs to the peptidase S1 family. (712 aa)
	HJV	Hemojuvelin BMP co-receptor. (575 aa)
	IFT172	Uncharacterized protein. (1748 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (420 aa)
	FXN	Frataxin. (235 aa)
	ECEL1	Endothelin converting enzyme like 1. (761 aa)
	ENSTGUP00000019857	annotation not available (66 aa)
	SPCS2	Signal peptidase complex subunit 2. (87 aa)
	PCSK2	Proprotein convertase subtilisin/kexin type 2; Belongs to the peptidase S8 family. (657 aa)
	ECE1	Endothelin converting enzyme 1. (756 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (469 aa)
	PHEX	Phosphate regulating endopeptidase homolog X-linked. (751 aa)
	ENSTGUP00000024522	annotation not available (197 aa)
	ENSTGUP00000024690	annotation not available (757 aa)
	LGMN	Uncharacterized protein. (431 aa)
	BMP1	Bone morphogenetic protein 1 isoform X1. (1475 aa)
	ASPH	Aspartate beta-hydroxylase. (749 aa)
	H1A298_TAEGU	Uncharacterized protein. (362 aa)
	DHH	Desert hedgehog protein isoform X2. (414 aa)
	TYSND1	Peroxisomal leader peptide-processing protease. (516 aa)
	MME	Membrane metalloendopeptidase. (750 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	CLN5	Uncharacterized protein. (352 aa)
	DDI2	Ubiquitin-like domain-containing protein. (430 aa)
	ATP23	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (455 aa)
	MIPEP	Mitochondrial intermediate peptidase. (728 aa)
	CASP8	Caspase 8. (480 aa)
	IL1R2	Interleukin 1 receptor type 2. (469 aa)
	LOC115492109	Prenyl protein peptidase. (314 aa)
	AFG3L2	AFG3 like matrix AAA peptidase subunit 2. (844 aa)
	PRR14L	Tantalus domain-containing protein. (2318 aa)
	PMPCA	Peptidase, mitochondrial processing alpha subunit; Belongs to the peptidase M16 family. (552 aa)
	MYRF	Uncharacterized protein. (1126 aa)
	TMPRSS4	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (499 aa)
	CTSL	Uncharacterized protein; Belongs to the peptidase C1 family. (338 aa)
	FADD	Fas associated via death domain. (221 aa)
	SDE2	SDE2 telomere maintenance homolog. (451 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (558 aa)
	PLAU	Uncharacterized protein. (457 aa)
	IHH	Indian hedgehog signaling molecule. (408 aa)
	IMMP1L	Mitochondrial inner membrane protease subunit. (207 aa)
	ENSTGUP00000038471	annotation not available (109 aa)
	PISD	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (423 aa)
	APH1A	Gamma-secretase subunit APH-1A isoform X1. (261 aa)
	PCSK7	Proprotein convertase subtilisin/kexin type 7. (869 aa)
	BACE1	Beta-secretase 1; Belongs to the peptidase A1 family. (496 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	MME	ENSTGUP00000002032	ENSTGUP00000026975	Angiotensin-converting enzyme.	Membrane metalloendopeptidase.	0.677
ACE	MMEL1	ENSTGUP00000002032	ENSTGUP00000002957	Angiotensin-converting enzyme.	Uncharacterized protein.	0.559
ADAM10	BACE1	ENSTGUP00000006279	ENSTGUP00000000190	ADAM metallopeptidase domain 10.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.403
ADAM10	ENSTGUP00000019857	ENSTGUP00000006279	ENSTGUP00000019857	ADAM metallopeptidase domain 10.	annotation not available	0.449
ADAM10	NCSTN	ENSTGUP00000006279	ENSTGUP00000004510	ADAM metallopeptidase domain 10.	Nicastrin.	0.639
ADAM10	PSEN1	ENSTGUP00000006279	ENSTGUP00000027530	ADAM metallopeptidase domain 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.540
ADAM10	PSEN2	ENSTGUP00000006279	ENSTGUP00000004463	ADAM metallopeptidase domain 10.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.469
ADAM10	SPG7	ENSTGUP00000006279	ENSTGUP00000008106	ADAM metallopeptidase domain 10.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.404
ADAM17	ENSTGUP00000019857	ENSTGUP00000013420	ENSTGUP00000019857	ADAM metallopeptidase domain 17.	annotation not available	0.449
ADAM17	FURIN	ENSTGUP00000013420	ENSTGUP00000010478	ADAM metallopeptidase domain 17.	Furin, paired basic amino acid cleaving enzyme.	0.474
ADAM17	NCSTN	ENSTGUP00000013420	ENSTGUP00000004510	ADAM metallopeptidase domain 17.	Nicastrin.	0.562
ADAM17	PCSK4	ENSTGUP00000013420	ENSTGUP00000000874	ADAM metallopeptidase domain 17.	Proprotein convertase subtilisin/kexin type 4.	0.474
AFG3L2	LONP2	ENSTGUP00000031476	ENSTGUP00000008955	AFG3 like matrix AAA peptidase subunit 2.	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-.	0.609
AFG3L2	MIPEP	ENSTGUP00000031476	ENSTGUP00000030260	AFG3 like matrix AAA peptidase subunit 2.	Mitochondrial intermediate peptidase.	0.444
AFG3L2	OMA1	ENSTGUP00000031476	ENSTGUP00000009955	AFG3 like matrix AAA peptidase subunit 2.	OMA1 zinc metallopeptidase.	0.677
AFG3L2	PARL	ENSTGUP00000031476	ENSTGUP00000005678	AFG3 like matrix AAA peptidase subunit 2.	Rhomboid domain-containing protein.	0.611
AFG3L2	PMPCA	ENSTGUP00000031476	ENSTGUP00000032849	AFG3 like matrix AAA peptidase subunit 2.	Peptidase, mitochondrial processing alpha subunit; Belongs to the peptidase M16 family.	0.837
AFG3L2	SPG7	ENSTGUP00000031476	ENSTGUP00000008106	AFG3 like matrix AAA peptidase subunit 2.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.850
AFG3L2	STOML2	ENSTGUP00000031476	ENSTGUP00000001831	AFG3 like matrix AAA peptidase subunit 2.	Stomatin like 2.	0.717
AFG3L2	YME1L1	ENSTGUP00000031476	ENSTGUP00000001153	AFG3 like matrix AAA peptidase subunit 2.	YME1 like 1 ATPase.	0.468