(31 nodes) Telencephalon cell migration network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ARX	Aristaless related homeobox. (567 aa)
	PAFAH1B1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (407 aa)
	SLIT2	Slit guidance ligand 2. (1541 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (473 aa)
	DIXDC1	DIX domain containing 1. (686 aa)
	RELN	Reelin. (3447 aa)
	SRF	Serum response factor. (485 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	DCX	Doublecortin. (365 aa)
	PEX13	SH3 domain-containing protein. (394 aa)
	SLIT1	Slit guidance ligand 1. (1538 aa)
	SUN2	Sad1 and UNC84 domain containing 2. (713 aa)
	EFHC1	EF-hand domain containing 1. (675 aa)
	ENSTGUP00000020883	Homeobox protein aristaless-related. (294 aa)
	LRRK2	Leucine rich repeat kinase 2. (2509 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (396 aa)
	ADGRG1	G_PROTEIN_RECEP_F2_4 domain-containing protein. (852 aa)
	ENSTGUP00000036887	annotation not available (442 aa)
	H0ZWH6_TAEGU	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (1355 aa)
	SUN1	SUN domain-containing protein. (904 aa)
	CDK5	Cyclin-dependent-like kinase 5. (808 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	ENSTGUP00000025988	annotation not available (559 aa)
	FBXO45	F-box protein 45. (272 aa)
	FOXG1	Forkhead box protein G1. (459 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator 1. (297 aa)
	BMERB1	BMERB domain containing 1. (233 aa)
	NRG3	Neuregulin 3. (425 aa)
	HTR6	G_PROTEIN_RECEP_F1_2 domain-containing protein. (424 aa)
	LRP8	LDL receptor related protein 8. (964 aa)
	DISC1	DISC1 scaffold protein. (852 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK5	CDK5R1	ENSTGUP00000030783	ENSTGUP00000024435	Cyclin-dependent-like kinase 5.	Cyclin-dependent kinase 5 activator 1.	0.993
CDK5	PSEN1	ENSTGUP00000030783	ENSTGUP00000027530	Cyclin-dependent-like kinase 5.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.571
CDK5R1	CDK5	ENSTGUP00000024435	ENSTGUP00000030783	Cyclin-dependent kinase 5 activator 1.	Cyclin-dependent-like kinase 5.	0.993
CDK5R1	PAFAH1B1	ENSTGUP00000024435	ENSTGUP00000009064	Cyclin-dependent kinase 5 activator 1.	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family.	0.507
CTNNB1	FOXG1	ENSTGUP00000004945	ENSTGUP00000024986	Catenin beta 1.	Forkhead box protein G1.	0.618
CTNNB1	PSEN1	ENSTGUP00000004945	ENSTGUP00000027530	Catenin beta 1.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.984
DCX	PAFAH1B1	ENSTGUP00000006366	ENSTGUP00000009064	Doublecortin.	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family.	0.458
DISC1	DIXDC1	ENSTGUP00000021730	ENSTGUP00000000321	DISC1 scaffold protein.	DIX domain containing 1.	0.568
DISC1	DRD2	ENSTGUP00000021730	ENSTGUP00000000268	DISC1 scaffold protein.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.521
DIXDC1	DISC1	ENSTGUP00000000321	ENSTGUP00000021730	DIX domain containing 1.	DISC1 scaffold protein.	0.568
DRD2	DISC1	ENSTGUP00000000268	ENSTGUP00000021730	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	DISC1 scaffold protein.	0.521
FOXG1	CTNNB1	ENSTGUP00000024986	ENSTGUP00000004945	Forkhead box protein G1.	Catenin beta 1.	0.618
FOXG1	SRF	ENSTGUP00000024986	ENSTGUP00000004884	Forkhead box protein G1.	Serum response factor.	0.720
LRP8	RELN	ENSTGUP00000022590	ENSTGUP00000002962	LDL receptor related protein 8.	Reelin.	0.900
PAFAH1B1	CDK5R1	ENSTGUP00000009064	ENSTGUP00000024435	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family.	Cyclin-dependent kinase 5 activator 1.	0.507
PAFAH1B1	DCX	ENSTGUP00000009064	ENSTGUP00000006366	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family.	Doublecortin.	0.458
PSEN1	CDK5	ENSTGUP00000027530	ENSTGUP00000030783	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Cyclin-dependent-like kinase 5.	0.571
PSEN1	CTNNB1	ENSTGUP00000027530	ENSTGUP00000004945	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Catenin beta 1.	0.984
RELN	LRP8	ENSTGUP00000002962	ENSTGUP00000022590	Reelin.	LDL receptor related protein 8.	0.900
RELN	SLIT1	ENSTGUP00000002962	ENSTGUP00000010134	Reelin.	Slit guidance ligand 1.	0.484