(51 nodes) Gland morphogenesis network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ELF3	E74 like ETS transcription factor 3. (368 aa)
	AREG	Amphiregulin. (195 aa)
	H0YUE5_TAEGU	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (590 aa)
	EPHA2	EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (239 aa)
	IL6	Interleukin 6. (221 aa)
	AR	Androgen receptor. (684 aa)
	MSN	Moesin. (580 aa)
	SOX9	SRY-box transcription factor 9. (474 aa)
	ETV4	ETS variant 4. (453 aa)
	MST1	Macrophage stimulating 1. (705 aa)
	DAG1	Dystroglycan 1. (896 aa)
	RXFP1	Relaxin family peptide receptor 1. (766 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (768 aa)
	NKX2-3	NK2 homeobox 3. (327 aa)
	EDAR	Ectodysplasin A receptor. (463 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (504 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (621 aa)
	LOC115493455	a_DG1_N2 domain-containing protein. (579 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (529 aa)
	ESRP2	Epithelial splicing regulatory protein 2. (727 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (269 aa)
	LOC100222335	EGF-like domain-containing protein. (158 aa)
	BAX	BCL2 associated X, apoptosis regulator. (225 aa)
	BTRC	Uncharacterized protein. (667 aa)
	HOXD13	Homeobox domain-containing protein. (312 aa)
	SCRIB	Scribble planar cell polarity protein. (1623 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	SEMA3C	Uncharacterized protein; Belongs to the semaphorin family. (751 aa)
	CSF1	Macrophage colony-stimulating factor 1 precursor. (498 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (702 aa)
	ENSTGUP00000023270	annotation not available (573 aa)
	NRG3	Neuregulin 3. (425 aa)
	ENSTGUP00000023855	annotation not available (1612 aa)
	ENSTGUP00000024315	annotation not available (176 aa)
	PLAG1	PLAG1 zinc finger. (501 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1595 aa)
	ENSTGUP00000026483	annotation not available (118 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
	PLXND1	Plexin D1. (1929 aa)
	CEBPB	CCAAT/enhancer-binding protein. (324 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (533 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (433 aa)
	FGL1	Fibrinogen like 1. (374 aa)
	CEBPB-2	CCAAT enhancer binding protein beta. (324 aa)
	GDF7	Growth differentiation factor 7. (369 aa)
	LRRC1	Leucine rich repeat containing 1. (795 aa)
	ENSTGUP00000034670	annotation not available (523 aa)
	LOC115498196	Protransforming growth factor alpha-like. (316 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ESR1	ENSTGUP00000002859	ENSTGUP00000011604	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.728
AR	H0YUE5_TAEGU	ENSTGUP00000002859	ENSTGUP00000001913	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.527
AR	MED1	ENSTGUP00000002859	ENSTGUP00000028044	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.527
AREG	EPHA2	ENSTGUP00000001600	ENSTGUP00000002121	Amphiregulin.	EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.672
AREG	LOC100222335	ENSTGUP00000001600	ENSTGUP00000015746	Amphiregulin.	EGF-like domain-containing protein.	0.601
AREG	LOC115498196	ENSTGUP00000001600	ENSTGUP00000035870	Amphiregulin.	Protransforming growth factor alpha-like.	0.601
BTRC	CUL3	ENSTGUP00000017175	ENSTGUP00000008239	Uncharacterized protein.	Cullin 3; Belongs to the cullin family.	0.918
CAV1	DAG1	ENSTGUP00000027745	ENSTGUP00000005324	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Dystroglycan 1.	0.460
CAV1	ESR1	ENSTGUP00000027745	ENSTGUP00000011604	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.767
CAV1	LOC115493455	ENSTGUP00000027745	ENSTGUP00000012558	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	a_DG1_N2 domain-containing protein.	0.460
CAV1	LRP5	ENSTGUP00000027745	ENSTGUP00000026054	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.484
CEBPB	ESR1	ENSTGUP00000029463	ENSTGUP00000011604	CCAAT/enhancer-binding protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.464
CEBPB-2	ESR1	ENSTGUP00000032270	ENSTGUP00000011604	CCAAT enhancer binding protein beta.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.464
CSF1	EPHA2	ENSTGUP00000022274	ENSTGUP00000002121	Macrophage colony-stimulating factor 1 precursor.	EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.667
CSF1	IL6	ENSTGUP00000022274	ENSTGUP00000002805	Macrophage colony-stimulating factor 1 precursor.	Interleukin 6.	0.519
CUL3	BTRC	ENSTGUP00000008239	ENSTGUP00000017175	Cullin 3; Belongs to the cullin family.	Uncharacterized protein.	0.918
DAG1	CAV1	ENSTGUP00000005324	ENSTGUP00000027745	Dystroglycan 1.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
EDA	EDAR	ENSTGUP00000002770	ENSTGUP00000009844	Ectodysplasin A; Belongs to the tumor necrosis factor family.	Ectodysplasin A receptor.	0.991
EDAR	EDA	ENSTGUP00000009844	ENSTGUP00000002770	Ectodysplasin A receptor.	Ectodysplasin A; Belongs to the tumor necrosis factor family.	0.991
EPHA2	AREG	ENSTGUP00000002121	ENSTGUP00000001600	EPH receptor A2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Amphiregulin.	0.672