(125 nodes) Signal release network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SNAP25	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
	EDN1	Endothelin 1. (202 aa)
	HNF1A	HNF1 homeobox A. (628 aa)
	FAM3B	Family with sequence similarity 3 member B. (331 aa)
	SYT9	Uncharacterized protein. (519 aa)
	GHRH	Growth hormone releasing hormone. (154 aa)
	ERC2	ELKS/RAB6-interacting/CAST family member 2. (956 aa)
	ANXA1	Annexin. (364 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (363 aa)
	SNAP23	Synaptosomal-associated protein; Belongs to the SNAP-25 family. (219 aa)
	H0YYC5_TAEGU	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (417 aa)
	STXBP1	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (715 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (428 aa)
	NRXN1	Neurexin 1. (1499 aa)
	LOC115491817	Protein lin-7 homolog B. (217 aa)
	RIMS3	Regulating synaptic membrane exocytosis 3. (274 aa)
	P2RX1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (395 aa)
	SYT4	Uncharacterized protein. (571 aa)
	RPH3A	Rabphilin 3A. (675 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (486 aa)
	SNAP29	t-SNARE coiled-coil homology domain-containing protein. (249 aa)
	LIN7C	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (200 aa)
	SNAPIN	SNARE-associated protein Snapin. (120 aa)
	LRRC1	Leucine rich repeat containing 1. (795 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	RIMS2	Uncharacterized protein. (1488 aa)
	STX2	Syntaxin 2; Belongs to the syntaxin family. (593 aa)
	RAB11FIP2	RAB11 family interacting protein 2. (502 aa)
	SLC16A2	Uncharacterized protein. (551 aa)
	TBX3	T-box transcription factor TBX3. (731 aa)
	SYN3	Synapsin_C domain-containing protein. (569 aa)
	GNRH1	Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (357 aa)
	ENSTGUP00000030594	annotation not available (231 aa)
	SYT12	Synaptotagmin 12. (472 aa)
	LOC115494778	Treacle protein-like. (779 aa)
	ENSTGUP00000029288	Syntaxin-1B-like. (211 aa)
	PORCN	Protein-serine O-palmitoleoyltransferase porcupine. (522 aa)
	CADPS	Uncharacterized protein. (1355 aa)
	ENSTGUP00000028843	annotation not available (398 aa)
	LEP	Taeniopygia guttata leptin (LEP), mRNA. (168 aa)
	NRXN2	Neurexin 2. (1546 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1026 aa)
	DOC2B	Double C2-like domain-containing protein beta. (401 aa)
	LOC115492697	Uncharacterized LOC115492697. (573 aa)
	SLC30A3	Solute carrier family 30 member 3. (382 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	ENSTGUP00000026997	annotation not available (687 aa)
	LIN7B	Lin-7 homolog B, crumbs cell polarity complex component. (98 aa)
	H0ZR32_TAEGU	Uncharacterized protein; Belongs to the potassium channel family. (510 aa)
	ILDR1	Immunoglobulin like domain containing receptor 1. (540 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1606 aa)
	CPLX1	Complexin 1. (164 aa)
	NR3C2	Nuclear receptor subfamily 3 group C member 2. (1010 aa)
	CCDC186	Coiled-coil domain containing 186. (919 aa)
	H0YPK2_TAEGU	Uncharacterized protein. (1716 aa)
	FFAR4	Free fatty acid receptor 4. (354 aa)
	TRARG1	Trafficking regulator of GLUT4 1. (176 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (691 aa)
	LYN	Tyrosine-protein kinase. (605 aa)
	LOC100225657-2	Protein wntless homolog. (541 aa)
	LIN7A	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (267 aa)
	CADPS2	Uncharacterized protein. (1301 aa)
	NEUROD1	Neurogenic differentiation factor 1 isoform X1. (363 aa)
	ENSTGUP00000023855	annotation not available (1612 aa)
	NT5DC2	5'-nucleotidase domain containing 2. (497 aa)
	ENSTGUP00000023319	annotation not available (371 aa)
	LOC100221701	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (460 aa)
	NIBAN2	Niban apoptosis regulator 2. (964 aa)
	CRHR2	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (427 aa)
	ADCYAP1	Adenylate cyclase activating polypeptide 1. (172 aa)
	ENSTGUP00000022493	annotation not available (159 aa)
	ENSTGUP00000022270	annotation not available (371 aa)
	LOC115495260	Endothelin receptor type B-like. (493 aa)
	CREB1	cAMP responsive element binding protein 1. (324 aa)
	LOC100218415-2	Complexin-3-like. (157 aa)
	ERC1	ELKS/RAB6-interacting/CAST family member 1. (1093 aa)
	ENSTGUP00000020579	annotation not available (505 aa)
	STXBP3	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (594 aa)
	RPH3AL	Double C2 domain beta. (310 aa)
	SYNJ1	Synaptojanin 1. (1557 aa)
	SCRIB	Scribble planar cell polarity protein. (1623 aa)
	CPLX2	Complexin-1/2. (125 aa)
	SELENOM	Selenoprotein M. (111 aa)
	H0ZYT8_TAEGU	Uncharacterized protein. (1509 aa)
	GPR119	G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (314 aa)
	CPLX4	Complexin 4. (160 aa)
	PINK1	PTEN induced kinase 1. (515 aa)
	STX19	Syntaxin 19; Belongs to the syntaxin family. (292 aa)
	MAFA	MAF bZIP transcription factor A. (288 aa)
	GPR68	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	CYB5R4	Cytochrome b5 reductase 4. (512 aa)
	SLC30A8	Uncharacterized protein. (320 aa)
	SLC16A10	Solute carrier family 16 member 10. (520 aa)
	SELENOT	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
	SUCNR1	Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (303 aa)
	NT5DC3	5'-nucleotidase domain containing 3. (547 aa)
	VIP	Vasoactive intestinal peptide. (215 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	STX11	Syntaxin 11. (288 aa)
	LOC100225657	Wnt ligand secretion mediator. (541 aa)
	TMF1	TATA element modulatory factor 1. (1103 aa)
	SNAP47	Synaptosome associated protein 47. (506 aa)
	GHRHR	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (425 aa)
	SYK	Tyrosine-protein kinase. (668 aa)
	SNX19	Sorting nexin 19. (943 aa)
	SYT2	Synaptotagmin 2. (415 aa)
	UNC13B	Unc-13 homolog B. (1625 aa)
	SYN2	Synapsin II. (586 aa)
	LOC100218415	Complexin 3. (157 aa)
	STX1A	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (313 aa)
	STX1B	Syntaxin-1B isoform X1. (288 aa)
	PDZD11	PDZ domain-containing protein. (194 aa)
	PARK7	Putative Parkinson disease autosomal recessive early onset 7 variant 1. (233 aa)
	SYTL4	Synaptotagmin like 4. (717 aa)
	GATA3	GATA binding protein 3. (443 aa)
	INHBA	Inhibin subunit beta A. (559 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1145 aa)
	HNF1B	HNF1 homeobox B. (531 aa)
	TBX2	TBX domain-containing protein. (653 aa)
	GLP1R	Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (459 aa)
	SYT1	Synaptotagmin I. (425 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (660 aa)
	UNC13C	Unc-13 homolog C. (2206 aa)
	SYT7	Synaptotagmin 7. (684 aa)
	STX3	Syntaxin 3. (331 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR1C	ENSTGUP00000028843	ENSTGUP00000038228	ENSTGUP00000028843	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	annotation not available	0.762
ACVR1C	INHBA	ENSTGUP00000038228	ENSTGUP00000001898	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	Inhibin subunit beta A.	0.778
ADCYAP1	CREB1	ENSTGUP00000022510	ENSTGUP00000021516	Adenylate cyclase activating polypeptide 1.	cAMP responsive element binding protein 1.	0.822
ADCYAP1	CRHR2	ENSTGUP00000022510	ENSTGUP00000022897	Adenylate cyclase activating polypeptide 1.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.545
ADCYAP1	GHRHR	ENSTGUP00000022510	ENSTGUP00000000347	Adenylate cyclase activating polypeptide 1.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.789
ADCYAP1	GLP1R	ENSTGUP00000022510	ENSTGUP00000007990	Adenylate cyclase activating polypeptide 1.	Glucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family.	0.567
ADCYAP1	H0YYC5_TAEGU	ENSTGUP00000022510	ENSTGUP00000037310	Adenylate cyclase activating polypeptide 1.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.545
CADPS	RIMS2	ENSTGUP00000029191	ENSTGUP00000033110	Uncharacterized protein.	Uncharacterized protein.	0.555
CADPS2	RIMS2	ENSTGUP00000024447	ENSTGUP00000033110	Uncharacterized protein.	Uncharacterized protein.	0.555
CADPS2	STX1A	ENSTGUP00000024447	ENSTGUP00000003701	Uncharacterized protein.	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.	0.406
CCDC186	TMF1	ENSTGUP00000025907	ENSTGUP00000010032	Coiled-coil domain containing 186.	TATA element modulatory factor 1.	0.450
CPLX1	ENSTGUP00000020579	ENSTGUP00000026147	ENSTGUP00000020579	Complexin 1.	annotation not available	0.618
CPLX1	ENSTGUP00000022270	ENSTGUP00000026147	ENSTGUP00000022270	Complexin 1.	annotation not available	0.618
CPLX1	ENSTGUP00000023319	ENSTGUP00000026147	ENSTGUP00000023319	Complexin 1.	annotation not available	0.618
CPLX1	ENSTGUP00000029288	ENSTGUP00000026147	ENSTGUP00000029288	Complexin 1.	Syntaxin-1B-like.	0.581
CPLX1	RIMS1	ENSTGUP00000026147	ENSTGUP00000026348	Complexin 1.	Regulating synaptic membrane exocytosis 1.	0.488
CPLX1	RIMS2	ENSTGUP00000026147	ENSTGUP00000033110	Complexin 1.	Uncharacterized protein.	0.507
CPLX1	RIMS3	ENSTGUP00000026147	ENSTGUP00000036354	Complexin 1.	Regulating synaptic membrane exocytosis 3.	0.488
CPLX1	SNAP23	ENSTGUP00000026147	ENSTGUP00000038044	Complexin 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.661
CPLX1	SNAP25	ENSTGUP00000026147	ENSTGUP00000006316	Complexin 1.	Synaptosomal-associated protein; Belongs to the SNAP-25 family.	0.945