(49 nodes) Cortical actin cytoskeleton network (Taeniopygia guttata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDLIM7	PDZ and LIM domain 7. (908 aa)
	PPP1R9A	Protein phosphatase 1 regulatory subunit 9A. (1339 aa)
	CIB2	Uncharacterized protein. (192 aa)
	MLPH	RabBD domain-containing protein. (676 aa)
	CTTN	Cortactin. (548 aa)
	FLOT2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	LLGL2	LLGL scribble cell polarity complex component 2. (1025 aa)
	PJVK	Gasdermin domain-containing protein. (357 aa)
	WDR1	WD_REPEATS_REGION domain-containing protein. (607 aa)
	NF2	Neurofibromin 2. (595 aa)
	MAEA	Macrophage erythroblast attacher. (434 aa)
	SPTBN5	Uncharacterized protein. (3814 aa)
	CALD1	Caldesmon 1. (569 aa)
	LLGL1	Lgl_C domain-containing protein. (1106 aa)
	MYO1A	Myosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1075 aa)
	HCLS1	Hematopoietic cell-specific Lyn substrate 1. (526 aa)
	SPTAN1	Uncharacterized protein. (2476 aa)
	ENSTGUP00000018771	annotation not available (490 aa)
	FLOT1	Flotillin-1. (451 aa)
	CLDN5	Claudin-5. (216 aa)
	SLC2A1	Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (544 aa)
	ACTR2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (407 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (912 aa)
	COBL	Uncharacterized protein. (1393 aa)
	LOC100230978	FERM domain-containing protein. (660 aa)
	ANLN	Anillin actin binding protein. (1285 aa)
	H0ZUY1_TAEGU	Uncharacterized protein. (2473 aa)
	LOC100217844	Uncharacterized protein. (1373 aa)
	ENSTGUP00000027548	annotation not available (629 aa)
	DBNL	Drebrin-like protein. (460 aa)
	MYO1B	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1136 aa)
	SHROOM3	Shroom family member 3. (2010 aa)
	MTSS2	MTSS I-BAR domain containing 2. (799 aa)
	LOC105759663	Alpha-actinin-4. (925 aa)
	ENSTGUP00000032701	annotation not available (476 aa)
	SHROOM2	Shroom family member 2. (1753 aa)
	ENSTGUP00000034692	annotation not available (1291 aa)
	DBN1	Drebrin 1. (699 aa)
	MYRIP	Rab_eff_C domain-containing protein. (895 aa)
	COTL1	Coactosin like F-actin binding protein 1. (431 aa)
	ENSTGUP00000035857	annotation not available (2309 aa)
	ACTN1	Actinin alpha 1. (997 aa)
	LOC115493114	Flotillin-1-like. (451 aa)
	ENSTGUP00000036196	annotation not available (2347 aa)
	PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2. (1678 aa)
	GOLGB1	Golgin B1. (3156 aa)
	LOC100226810	ASD1 domain-containing protein. (1329 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2364 aa)
	VCL	Uncharacterized protein. (1068 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN1	PDLIM7	ENSTGUP00000036000	ENSTGUP00000000418	Actinin alpha 1.	PDZ and LIM domain 7.	0.442
ACTN1	VCL	ENSTGUP00000036000	ENSTGUP00000037698	Actinin alpha 1.	Uncharacterized protein.	0.975
ACTR2	COTL1	ENSTGUP00000021594	ENSTGUP00000035569	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Coactosin like F-actin binding protein 1.	0.489
ACTR2	CTTN	ENSTGUP00000021594	ENSTGUP00000005724	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Cortactin.	0.957
ACTR2	DBN1	ENSTGUP00000021594	ENSTGUP00000035092	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Drebrin 1.	0.607
ACTR2	DBNL	ENSTGUP00000021594	ENSTGUP00000028174	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Drebrin-like protein.	0.607
ACTR2	ENSTGUP00000027548	ENSTGUP00000021594	ENSTGUP00000027548	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	annotation not available	0.607
ACTR2	GOLGB1	ENSTGUP00000021594	ENSTGUP00000036649	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Golgin B1.	0.471
ACTR2	HCLS1	ENSTGUP00000021594	ENSTGUP00000016332	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Hematopoietic cell-specific Lyn substrate 1.	0.957
ACTR2	MYO1A	ENSTGUP00000021594	ENSTGUP00000016034	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Myosin IA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.535
ACTR2	MYO1B	ENSTGUP00000021594	ENSTGUP00000030341	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.535
ACTR2	VCL	ENSTGUP00000021594	ENSTGUP00000037698	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	Uncharacterized protein.	0.609
ACTR2	WDR1	ENSTGUP00000021594	ENSTGUP00000010198	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	WD_REPEATS_REGION domain-containing protein.	0.633
ANLN	FLOT1	ENSTGUP00000025294	ENSTGUP00000019444	Anillin actin binding protein.	Flotillin-1.	0.496
ANLN	FLOT2	ENSTGUP00000025294	ENSTGUP00000006414	Anillin actin binding protein.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.496
ANLN	LOC115493114	ENSTGUP00000025294	ENSTGUP00000036190	Anillin actin binding protein.	Flotillin-1-like.	0.496
CDH2	VCL	ENSTGUP00000023877	ENSTGUP00000037698	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.472
COTL1	ACTR2	ENSTGUP00000035569	ENSTGUP00000021594	Coactosin like F-actin binding protein 1.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.489
CTTN	ACTR2	ENSTGUP00000005724	ENSTGUP00000021594	Cortactin.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.957
CTTN	HCLS1	ENSTGUP00000005724	ENSTGUP00000016332	Cortactin.	Hematopoietic cell-specific Lyn substrate 1.	0.903