(86 nodes) Regulation of TOR signaling network (Taeniopygia guttata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	ENSTGUP00000023767	annotation not available (564 aa)
	WAC	WW domain containing adaptor with coiled-coil. (645 aa)
	LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (244 aa)
	LOC115498158	Transmembrane protein 127. (237 aa)
	PIH1D1	LOW QUALITY PROTEIN: PIH1 domain-containing protein 1. (346 aa)
	C9orf72	C9orf72-SMCR8 complex subunit. (481 aa)
	SESN2	Uncharacterized protein. (616 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (397 aa)
	LAMTOR3	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity). (124 aa)
	BMT2	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (484 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1. (347 aa)
	LEP	Taeniopygia guttata leptin (LEP), mRNA. (168 aa)
	PKHD1	Uncharacterized protein. (3650 aa)
	GPR137C	G protein-coupled receptor 137C. (233 aa)
	ENSTGUP00000027602	annotation not available (185 aa)
	RRAGB	Uncharacterized protein. (512 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (710 aa)
	WDR59	WD repeat domain 59. (992 aa)
	H0ZAX6_TAEGU	Uncharacterized protein. (508 aa)
	LAMTOR5	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (128 aa)
	CASTOR2	Uncharacterized protein. (329 aa)
	RRAGC	Ras related GTP binding C. (409 aa)
	HTR6	G_PROTEIN_RECEP_F1_2 domain-containing protein. (424 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (469 aa)
	MLST8	MTOR associated protein, LST8 homolog. (325 aa)
	CTNS	Cystinosin, lysosomal cystine transporter. (367 aa)
	TSC2	TSC complex subunit 2. (1835 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
	SESN3	Uncharacterized protein. (488 aa)
	TELO2	Telomere maintenance 2. (926 aa)
	SLC38A9	Solute carrier family 38 member 9. (559 aa)
	RNF152	E3 ubiquitin-protein ligase RNF152. (203 aa)
	ENSTGUP00000018652	Lysosomal acid glucosylceramidase-like. (536 aa)
	GNA12	G protein subunit alpha 12. (385 aa)
	LOC100227578	Glucosylceramidase. (522 aa)
	LOC115498459	Glucosylceramidase. (524 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	ITFG2	Integrin alpha FG-GAP repeat containing 2. (457 aa)
	ATM	Non-specific serine/threonine protein kinase. (2226 aa)
	RRAGD	Ras related GTP binding D. (400 aa)
	SESN1	Sestrin 1. (538 aa)
	TNFAIP8L1	TNF alpha induced protein 8 like 1. (419 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (561 aa)
	LOC115492746	Ragulator complex protein LAMTOR4-like. (117 aa)
	ROS1	Tyrosine-protein kinase receptor. (2290 aa)
	FBXO9	F-box protein 9. (436 aa)
	OTUD5	OTU deubiquitinase 5. (466 aa)
	ENSTGUP00000036051	annotation not available (475 aa)
	ENSTGUP00000036438	annotation not available (154 aa)
	GAS6	Growth arrest specific 6. (704 aa)
	ENSTGUP00000037445	annotation not available (1058 aa)
	C12orf66	Chromosome 12 open reading frame 66. (446 aa)
	LOC100226756	FAM83 domain-containing protein. (565 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1755 aa)
	CASTOR1	ACT_7 domain-containing protein. (367 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa)
	GPR137B	G protein-coupled receptor 137B. (385 aa)
	KLHL22	BTB domain-containing protein. (638 aa)
	DEPDC5	DEP domain-containing protein. (1601 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	SEH1L	SEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (466 aa)
	TMEM130	Transmembrane protein 130. (422 aa)
	MINAR1	Membrane integral NOTCH2 associated receptor 1. (920 aa)
	SZT2	Uncharacterized protein. (163 aa)
	SMCR8	SMCR8-C9orf72 complex subunit. (904 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (471 aa)
	TBC1D7	Rab-GAP TBC domain-containing protein. (293 aa)
	TSC1	Uncharacterized protein. (1175 aa)
	CLEC16A	C-type lectin domain containing 16A. (1036 aa)
	NPRL2	NPR2 like, GATOR1 complex subunit. (439 aa)
	LOC115497915	FAM83 domain-containing protein. (408 aa)
	DDIT4	DNA damage inducible transcript 4. (192 aa)
	LAMTOR2	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity). (125 aa)
	WDR24	WD repeat domain 24. (789 aa)
	SIRT1	Sirtuin 1. (750 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1778 aa)
	SH3BP4	SH3 domain binding protein 4. (1068 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1358 aa)
	RICTOR	RPTOR independent companion of MTOR complex 2. (1713 aa)
	GOLPH3	Golgi phosphoprotein 3. (313 aa)
	MIOS	Meiosis regulator for oocyte development. (859 aa)
	DGKQ	Diacylglycerol kinase. (938 aa)
	FNIP1	Folliculin interacting protein 1. (1183 aa)
	SIK3	SIK family kinase 3. (1339 aa)
	LARS1	Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (1177 aa)
	LAMTOR4	Ragulator complex protein LAMTOR4 isoform X1. (99 aa)

Your Current Organism:

Taeniopygia guttata

NCBI taxonomy Id: 59729
Other names: Poephila guttata, T. guttata, Taenopygia guttata, zebra finch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	H0ZAX6_TAEGU	ENSTGUP00000013001	ENSTGUP00000024278	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.416
ATM	PRKAA1	ENSTGUP00000013001	ENSTGUP00000033501	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.531
ATM	SIRT1	ENSTGUP00000013001	ENSTGUP00000003586	Non-specific serine/threonine protein kinase.	Sirtuin 1.	0.643
ATM	TELO2	ENSTGUP00000013001	ENSTGUP00000019735	Non-specific serine/threonine protein kinase.	Telomere maintenance 2.	0.865
BMT2	C12orf66	ENSTGUP00000028997	ENSTGUP00000037904	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Chromosome 12 open reading frame 66.	0.895
BMT2	DEPDC5	ENSTGUP00000028997	ENSTGUP00000010208	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	DEP domain-containing protein.	0.845
BMT2	ENSTGUP00000023767	ENSTGUP00000028997	ENSTGUP00000023767	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	annotation not available	0.642
BMT2	ENSTGUP00000037445	ENSTGUP00000028997	ENSTGUP00000037445	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	annotation not available	0.642
BMT2	ITFG2	ENSTGUP00000028997	ENSTGUP00000013543	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Integrin alpha FG-GAP repeat containing 2.	0.868
BMT2	LAMTOR1	ENSTGUP00000028997	ENSTGUP00000031802	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1.	0.424
BMT2	LAMTOR2	ENSTGUP00000028997	ENSTGUP00000003776	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Ragulator complex protein LAMTOR2; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.434
BMT2	LAMTOR3	ENSTGUP00000028997	ENSTGUP00000030181	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Ragulator complex protein LAMTOR3; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade (By similarity).	0.442
BMT2	LAMTOR5	ENSTGUP00000028997	ENSTGUP00000023972	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5.	0.433
BMT2	MLST8	ENSTGUP00000028997	ENSTGUP00000022014	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	MTOR associated protein, LST8 homolog.	0.566
BMT2	NPRL2	ENSTGUP00000028997	ENSTGUP00000004815	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR2 like, GATOR1 complex subunit.	0.775
BMT2	NPRL3	ENSTGUP00000028997	ENSTGUP00000026872	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	NPR3 like, GATOR1 complex subunit.	0.750
BMT2	RPTOR	ENSTGUP00000028997	ENSTGUP00000003147	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Regulatory associated protein of MTOR complex 1.	0.462
BMT2	RRAGB	ENSTGUP00000028997	ENSTGUP00000027219	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	Uncharacterized protein.	0.541
C12orf66	BMT2	ENSTGUP00000037904	ENSTGUP00000028997	Chromosome 12 open reading frame 66.	S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]	0.895
C12orf66	CASTOR1	ENSTGUP00000037904	ENSTGUP00000010868	Chromosome 12 open reading frame 66.	ACT_7 domain-containing protein.	0.603